2019
Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2019, 37: 745-753. PMID: 31121635, DOI: 10.1055/s-0039-1688909.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidBiomarkersChorioamnionitisEchocardiography, DopplerFemaleFetal BloodFetal HeartHumansInfant, NewbornInfant, PrematureInflammationInterleukin-6MaleMass SpectrometryNatriuretic Peptide, BrainPeptide FragmentsPlacentaPregnancyPremature BirthVentricular Function, LeftConceptsIntra-amniotic infection/inflammationBrain natriuretic proteinAmniotic fluidNT-proBNPTei indexNatriuretic proteinVentricular functionFetal exposureCord bloodCord IL-6Intra-amniotic inflammationFetal myocardial functionInfection/inflammationBlood NT-proBNPFetal heart functionNT-proBNP immunoassaysEnzyme-linked immunosorbentGestational agePremature fetusesFetal echocardiogramIL-6Circulatory levelsMyocardial functionHeart functionFetuses
2000
The clinical significance of the irregular fetal heart rhythm
Copel J, Liang R, Demasio K, Ozeren S, Kleinman C. The clinical significance of the irregular fetal heart rhythm. American Journal Of Obstetrics And Gynecology 2000, 182: 813-819. PMID: 10764457, DOI: 10.1016/s0002-9378(00)70330-9.Peer-Reviewed Original ResearchConceptsFetal heart rhythmSignificant arrhythmiasHeart rhythmFetal echocardiographyStructural heart diseaseRoutine prenatal careRetrospective reviewFetal echocardiogramPrenatal careHeart diseaseFetal arrhythmiasClinical significanceClinical practiceArrhythmiasAppropriate managementFetusesIrregular rhythmNormal rhythmDifferent fetusesEchocardiographyRhythmImportant proportionLittle informationEchocardiogramNeonates
1997
The effect of intravascular blood transfusion on the flow velocity waveform of the portal venous system of the anemic fetus
d'Ancona R, Rahman F, Ozcan T, Copel J, Mari G. The effect of intravascular blood transfusion on the flow velocity waveform of the portal venous system of the anemic fetus. Ultrasound In Obstetrics And Gynecology 1997, 10: 333-337. PMID: 9444047, DOI: 10.1046/j.1469-0705.1997.10050333.x.Peer-Reviewed Original ResearchConceptsFlow velocity waveformsPortal venous systemAnemic fetusesVelocity waveformsPortal hypertensionIntravascular transfusionPortal veinVenous systemNormal fetusesIntravascular blood transfusionNon-pulsatile flowBlood transfusionRhesus alloimmunizationGestational agePulsatile patternTransfusionFetusesPresence of pulsatilityHypertensionIncreased numberCardiac cyclePulsatileVeinAlloimmunizationUteroPrenatal sonographic findings in 187 fetuses with Down syndrome
Rotmensch S, Liberati M, Bronshtein M, Schoenfeld‐Dimaio M, Shalev J, Ben‐Rafael Z, Copel J. Prenatal sonographic findings in 187 fetuses with Down syndrome. Prenatal Diagnosis 1997, 17: 1001-1009. PMID: 9399347, DOI: 10.1002/(sici)1097-0223(199711)17:11<1001::aid-pd186>3.0.co;2-x.Peer-Reviewed Original ResearchConceptsDown syndrome fetusesSonographic findingsSyndrome fetusesFetal karyotypeDown syndromeNuchal fold thicknessAbnormal sonographic findingsInternal organ abnormalitiesPrenatal sonographic findingsDown syndrome detectionEchogenic bowelWeeks' gestationUltrasound scanSame fetusCystic hygromaCardiac defectsConcurrent malformationsFold thicknessStructural abnormalitiesOrgan abnormalitiesFetusesSyndromeAbnormalitiesSyndrome detectionGestation
1996
Adrenal artery velocity waveforms in the appropriate and small‐for‐gestational‐age fetus
Mari G, Uerpairojkit B, Abuhamad A, Copel J. Adrenal artery velocity waveforms in the appropriate and small‐for‐gestational‐age fetus. Ultrasound In Obstetrics And Gynecology 1996, 8: 82-86. PMID: 8883308, DOI: 10.1046/j.1469-0705.1996.08020082.x.Peer-Reviewed Original ResearchConceptsGestational age fetusesArtery pulsatility indexFlow velocity waveformsPulsatility indexVelocity waveformsAdrenal arteryFetal heart rate decelerationsHeart rate decelerationsPreterm deliveryCesarean sectionGestational ageDoppler ultrasonographyAdrenal glandBlood flowHigh incidenceNormal fetusesFetusesRate decelerationConfidence intervalsSuccess rateArteryUltrasonographyGestationIncidence
1995
Abdominal venous system in the normal fetus.
Mari G, Uerpairojkit B, Copel J. Abdominal venous system in the normal fetus. Obstetrics And Gynecology 1995, 86: 729-33. PMID: 7566838, DOI: 10.1016/0029-7844(95)00264-r.Peer-Reviewed Original ResearchConceptsFlow velocity waveformsInferior vena cavaAbdominal venous systemUmbilical sinusNormal fetusesVena cavaPortal veinVenous systemVelocity waveformsDuctus venosusSplenic veinHepatic veinUmbilical veinCommon iliac veinLeft hepatic veinAdrenal veinWeeks' gestationRenal veinIliac veinAnterior divisionPosterior divisionMonophasic patternFetusesCavaBiphasic patternNormal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results
Bahado-Singh R, Goldstein I, Uerpairojkit B, Copel J, Mahoney M, Baumgarten A. Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results. American Journal Of Obstetrics And Gynecology 1995, 173: 1106-1110. PMID: 7485301, DOI: 10.1016/0002-9378(95)91334-3.Peer-Reviewed Original ResearchConceptsAbnormal triple-screen resultsTriple-screen resultsNuchal thicknessDown syndromeHuman chorionic gonadotropin levelsNuchal thickness measurementChorionic gonadotropin levelsReceiver operator characteristic curveNumber of amniocentesesReceiver operator characteristic plotsRisk thresholdMidtrimester pregnancyGonadotropin levelsWeeks' gestationMaternal ageConsecutive fetusesUnconjugated estriolSerum screeningEuploid fetusesAlpha-fetoproteinSyndromeTrisomy 21Screen resultsRisk estimatesFetusesUmbilical artery flow velocity waveforms in monoamniotic twins with cord entanglement.
Abuhamad A, Mari G, Copel J, Cantwell C, Evans A. Umbilical artery flow velocity waveforms in monoamniotic twins with cord entanglement. Obstetrics And Gynecology 1995, 86: 674-7. PMID: 7675410, DOI: 10.1016/0029-7844(95)00210-i.Peer-Reviewed Case Reports and Technical NotesConceptsUmbilical artery velocity waveformsFlow velocity waveformsCord entanglementMonoamniotic twinsVelocity waveformsUltrasonographic evidenceWeeks' gestationUmbilical artery flow velocity waveformsDoppler flow velocity waveformsMiddle cerebral arteryFetal-placental circulationTwin membersUmbilical cord entanglementAntepartum managementDoppler findingsCerebral arteryHemodynamic alterationsAntepartum periodUmbilical vesselsGestationPregnancyArteryFetusesSingle umbilical artery: Does it matter which artery is missing?
Abuhamad A, Shaffer W, Mari G, Copel J, Hobbins J, Evans A. Single umbilical artery: Does it matter which artery is missing? American Journal Of Obstetrics And Gynecology 1995, 173: 728-732. PMID: 7573234, DOI: 10.1016/0002-9378(95)90331-3.Peer-Reviewed Original ResearchConceptsSingle umbilical arteryGestational age fetusesUmbilical arteryLeft arteryCongenital anomaliesRight arteryIsolated single umbilical arteryComplex fetal anomaliesLeft umbilical arteryComplex congenital anomaliesProspective studyIsolated findingFetal anomaliesArteryCytogenetic abnormalitiesComplex anomaliesFetusesPregnancyPrevious reportsAbsenceAbnormalitiesIncidenceSonogramsManagement of the Rh-Sensitizeo Mother
Gollin Y, Copel J. Management of the Rh-Sensitizeo Mother. Clinics In Perinatology 1995, 22: 545-559. PMID: 8521681, DOI: 10.1016/s0095-5108(18)30268-9.ChaptersConceptsRh immune globulinManagement of complicationsRh D typingEarly referralIntrauterine transfusionImmune globulinRh isoimmunizationTertiary centerAnemic fetusesNeonatal careFetal bloodInvasive techniquesLung maturityPrompt identificationD typingClinical situationsOptimal managementFetusesMothersTransfusionComplicationsIsoimmunizationNeonatesNeonatologistsPerinatologistsDiagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization
Mari G, Adrignolo A, Abuhamad A, Pirhonen J, Jones D, Ludomirsky A, Copel J. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group immunization. Ultrasound In Obstetrics And Gynecology 1995, 5: 400-405. PMID: 7552802, DOI: 10.1046/j.1469-0705.1995.05060400.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, HemolyticBlood Flow VelocityBlood Group AntigensCerebral ArteriesCordocentesisErythroblastosis, FetalFemaleFetal BloodGestational AgeHumansInfant, NewbornObserver VariationPregnancyProspective StudiesRetrospective StudiesRh IsoimmunizationROC CurveTransfusion ReactionUltrasonography, Doppler, ColorUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMiddle cerebral artery peak systolic velocityPeak systolic velocitySystolic velocityFetal anemiaGroup AAnemic fetusesMiddle cerebral artery peak systolic velocity valuesMiddle cerebral artery peak velocityFetal middle cerebral artery peak systolic velocityPeak systolic velocity valuesSystolic velocity valuesPeak velocityNormal mean valueAnemia riskNon-invasive methodGroup B.Prospective fashionFetal hematocritGroup BDoppler ultrasoundGroup CNormal fetusesAnemiaFetusesNormal valuesFifth digit measurement in normal pregnancies: a potential sonographic sign of Down's syndrome
Goldstein I, Gomez K, Copel J. Fifth digit measurement in normal pregnancies: a potential sonographic sign of Down's syndrome. Ultrasound In Obstetrics And Gynecology 1995, 5: 34-37. PMID: 7850587, DOI: 10.1046/j.1469-0705.1995.05010034.x.Peer-Reviewed Original ResearchConceptsGestational ageFifth fingerBiparietal diameterDown syndromeFemoral lengthHumeral lengthRoutine biometric measurementsNormal pregnancyWeeks' gestationStudy groupSonographic signsNormal fetusesSyndromePrenatal detectionFurther studiesGestationAgeNormative dataFetusesBiometric measurementsFingerLinear growthDigit measurementsPregnancy
1994
The real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus.
Goldstein I, Gomez K, Copel J. The real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus. Obstetrics And Gynecology 1994, 83: 854-6. PMID: 8159375.Peer-Reviewed Case Reports and Technical NotesConceptsDoppler flow studiesCommon malignant tumorColor Doppler appearanceThird-trimester fetusesFlow mappingColor flow mappingFetal neuroblastomaAdrenal neuroblastomaWeeks' gestationUltrasound evaluationRenal poleDoppler appearanceMalignant tumorsColor DopplerUse of ultrasoundPrenatal recognitionNeuroblastomaGestationTumorsFlow studiesUltrasonographyFetusesDiagnosisWomen
1993
Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization.
Saade G, Moise K, Copel J, Belfort M, Carpenter R. Fetal platelet counts correlate with the severity of the anemia in red-cell alloimmunization. Obstetrics And Gynecology 1993, 82: 987-91. PMID: 8233277.Peer-Reviewed Original ResearchConceptsRed cell alloimmunizationFetal platelet countPlatelet countNonhydropic fetusesBilirubin levelsReticulocyte countMaternal red cell alloimmunizationLow platelet countStudent's t-testFetal plateletsHydropic fetusesIntrauterine transfusionFetal anemiaGestational ageInitial transfusionAnemic fetusesHematopoietic stem cellsFetusesAlloimmunizationThrombocytopeniaTransfusionRegression analysisT-testAnemiaHydropicErythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis.
Moya F, Grannum P, Widness J, Clemons G, Copel J, Hobbins J. Erythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis. Obstetrics And Gynecology 1993, 82: 353-8. PMID: 8355933.Peer-Reviewed Original ResearchConceptsRh isoimmunizationGestational agePlasma erythropoietinWeeks' gestationElective cesareanControl fetusesImmune hemolytic anemiaUmbilical cord plasmaHigh erythropoietin levelsUmbilical cord bloodCord plasmaLower hemoglobinInverse associationTerm fetusesCord bloodErythropoietin levelsHemolytic anemiaErythropoietin measurementsLate gestationHuman fetusesGestationFetusesIsoimmunizationAnemiaHemoglobinUltrasound screening for fetal structural anomalies
Gomez K, Copel J. Ultrasound screening for fetal structural anomalies. Current Opinion In Obstetrics & Gynecology 1993, 5: 204-210. PMID: 8490090, DOI: 10.1097/00001703-199304000-00006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFetal structural anomaliesStructural anomaliesRoutine ultrasound screeningFour-chamber viewNeural tube defectsRoutine ultrasoundUltrasound screeningHigh riskUltrasound prenatal diagnosisTube defectsUltrasoundPregnancyPrenatal diagnosisDiagnostic ultrasoundControversial topicPatientsObstetricsFetusesAmniocentesisDiagnosis
1992
Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination
Bahado-Singh R, Wyse L, Dorr M, Copel J, O'Connor T, Hobbins J. Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination. American Journal Of Obstetrics And Gynecology 1992, 167: 1009-1014. PMID: 1415385, DOI: 10.1016/s0002-9378(12)80029-9.Peer-Reviewed Original ResearchConceptsDown syndrome fetusesSyndrome fetusesFrontothalamic distanceDown syndromePositive predictive valueWeeks' gestationGestational ageNormal medianPosterior thalamusUltrasonographic examinationGroup 52Normal fetusesFrontal lobePredictive valueInner tableFetusesFrontal boneMedianGestationMean valueSyndromeManagement of the Fetus with Cardiac Disease
Baumann P, Copel J, Kleinman C. Management of the Fetus with Cardiac Disease. Ultrasound Quarterly 1992, 10: 57-78. DOI: 10.1097/00013644-199201020-00001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1991
Congenital Heart Disease and Fetal Thoracoabdominal Anomalies: Associations in Utero and the Importance of Cytogenetic Analysis
Fogel M, Copel J, Cullen M, Hobbins J, Kleinman C. Congenital Heart Disease and Fetal Thoracoabdominal Anomalies: Associations in Utero and the Importance of Cytogenetic Analysis. American Journal Of Perinatology 1991, 8: 411-416. PMID: 1839950, DOI: 10.1055/s-2007-999427.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePosterior diaphragmatic herniaDuodenal atresiaHeart diseaseExtracardiac malformationsDiaphragmatic herniaFetal echocardiographyNormal cardiac structureFetal echocardiogramMost fetusesPrenatal evaluationAbnormal karyotypeCardiac structureCytogenetic abnormalitiesFetusesAtresiaOmphaloceleNormal karyotypeAbnormalitiesDiseaseEchocardiographyGastroschisisHerniaPrenatal diagnosisMalformationsForamen ovale size in the normal and abnormal human fetal heart: an indicator of transatrial flow physiology
Feit L, Copel J, Kleinman C. Foramen ovale size in the normal and abnormal human fetal heart: an indicator of transatrial flow physiology. Ultrasound In Obstetrics And Gynecology 1991, 1: 313-319. PMID: 12797035, DOI: 10.1046/j.1469-0705.1991.01050313.x.Peer-Reviewed Original ResearchHeart obstructive lesionsLeft heart obstructive lesionsObstructive lesionsColor Doppler studyDoppler studiesForamen ovaleColor flow Doppler studiesNormal cardiac anatomyCongenital heart diseaseRight ventricular developmentNormal flow patternsHuman fetal heartWeeks' gestationVentricular sizeDoppler interrogationFetal echocardiographyHeart diseaseAtrial septumHelpful adjunctNormal fetusesHuman fetusesFetal heartLesionsFetusesCardiac anatomy