2020
Calcium‐induced calcium release in proximity to hair cell BK channels revealed by PKA activation
Bai J, Xue N, Lawal O, Nyati A, Santos‐Sacchi J, Navaratnam D. Calcium‐induced calcium release in proximity to hair cell BK channels revealed by PKA activation. Physiological Reports 2020, 8: e14449. PMID: 32748549, PMCID: PMC7399380, DOI: 10.14814/phy2.14449.Peer-Reviewed Original ResearchConceptsBK channelsBK currentsCalcium-activated potassium channelsLarge-conductance calcium-activated potassium channelsCalcium-induced calcium releaseEntry of CaSlo subunitSynaptic releaseCalcium releaseChicken hair cellsPotassium channelsHair cellsIP3 receptorCICRA ActivationPKA activationActivationCritical roleImagingReleaseRyanodine
2011
Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium
Frucht CS, Uduman M, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. Gene Expression Gradients along the Tonotopic Axis of the Chicken Auditory Epithelium. Journal Of The Association For Research In Otolaryngology 2011, 12: 423-435. PMID: 21399991, PMCID: PMC3123449, DOI: 10.1007/s10162-011-0259-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCalcium ChannelsChickensCyclic AMP-Dependent Protein KinasesGene Expression ProfilingGene Expression Regulation, DevelopmentalHair Cells, AuditoryLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMicroRNAsModels, AnimalOrgan of CortiProtein Kinase CSodium ChannelsConceptsGene expression gradientsAuditory epitheliumKinases protein kinase CChicken auditory epitheliumExpression gradientsAvian auditory epitheliumBasilar papillaFold-change cutoffActivity of kinasesIon channel genesProtein kinase CChicken basilar papillaGene setsGenetic basisEnrichment analysisExpression patternsGene expressionGeneSpring softwareChannel genesMechanism of inductionKinase CGenesMicroarray dataDifferential activityQuantitative PCRMicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium
Frucht CS, Santos-Sacchi J, Navaratnam DS. MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium. Neuroscience Letters 2011, 493: 44-48. PMID: 21316421, PMCID: PMC3065390, DOI: 10.1016/j.neulet.2011.02.017.Peer-Reviewed Original ResearchConceptsHair cell regenerationHair cell deathAuditory epitheliumChicken auditory epitheliumCell deathNon-mammalian vertebratesAvian auditory epitheliumCell regenerationHair cellsBasilar papillaNew hair cellsChicken basilar papillaAvian counterpartsOtotoxic injuryCaspase-3MiRNACellsMiR181aKey roleExplantsProliferationRegenerationBrdU-positive cellsVertebratesMammals
2010
Gene Expression Analysis of Forskolin Treated Basilar Papillae Identifies MicroRNA181a as a Mediator of Proliferation
Frucht CS, Uduman M, Duke JL, Kleinstein SH, Santos-Sacchi J, Navaratnam DS. Gene Expression Analysis of Forskolin Treated Basilar Papillae Identifies MicroRNA181a as a Mediator of Proliferation. PLOS ONE 2010, 5: e11502. PMID: 20634979, PMCID: PMC2901389, DOI: 10.1371/journal.pone.0011502.Peer-Reviewed Original ResearchConceptsNew hair cellsAuditory epitheliumChicken auditory epitheliumHair cellsInner ear developmentHair cell regenerationGene expression analysisAuditory hair cellsEar developmentExpression analysisMyosin VIEnrichment analysisCycle controlGene expressionMolecular eventsSingle microRNAMediator of proliferationRelevant pathwaysFunctional experimentsPost-hatch chicksRegenerating tissueMammalsGenesBrdU incorporationCell regeneration