2013
Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish
Ricci AJ, Bai JP, Song L, Lv C, Zenisek D, Santos-Sacchi J. Patch-Clamp Recordings from Lateral Line Neuromast Hair Cells of the Living Zebrafish. Journal Of Neuroscience 2013, 33: 3131-3134. PMID: 23407967, PMCID: PMC3684625, DOI: 10.1523/jneurosci.4265-12.2013.Peer-Reviewed Original ResearchConceptsHair cellsSynaptic vesicle releaseNeuromast hair cellsLiving zebrafishBiological discoveryIonic channel activityZebrafishVesicle releaseChannel activityPhysiological activityLateral lineJunctional couplingCellsDetailed understandingPatch-clamp recordingsVestibular peripheryFishNeuromastsActivityDiscoveryFirst recording
2000
Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ
Blasits S, Maune S, Santos-Sacchi J. Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ. Pflügers Archiv - European Journal Of Physiology 2000, 440: 710-712. PMID: 11007311, DOI: 10.1007/s004240000355.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclic GMPGap JunctionsGuinea PigsNitric OxideNitric Oxide DonorsNitroprussideOrgan of CortiConceptsDeiters' cellsCorti's organNO/cGMP pathwayNitric oxide donor sodium nitroprussideWhole-cell voltage-clamp conditionsNO synthase inhibitorUncouple gap junctionsNormal sensory functionDonor sodium nitroprussideGap junctionsVoltage-clamp conditionsOtotoxic mechanismsMinutes of applicationCGMP pathwayGap junctional communicationSodium nitroprussideSynthase inhibitorCochlear homeostasisSensory functionElectrical uncouplingNitric oxideCGMP analogJunctional communicationOrgansCellsVoltage Gating of Gap Junctions in Cochlear Supporting Cells: Evidence for Nonhomotypic Channels
Zhao H, Santos-Sacchi J. Voltage Gating of Gap Junctions in Cochlear Supporting Cells: Evidence for Nonhomotypic Channels. The Journal Of Membrane Biology 2000, 175: 17-24. PMID: 10811964, DOI: 10.1007/s002320001051.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsElectrophysiologyGap JunctionsGuinea PigsIon Channel GatingIon ChannelsOrgan of CortiCell coupling in Corti's organ
Santos-Sacchi J. Cell coupling in Corti's organ. Brain Research Reviews 2000, 32: 167-171. PMID: 10751666, DOI: 10.1016/s0165-0173(99)00077-6.Peer-Reviewed Original Research
1998
Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's Organ
Zhao H, Santos-Sacchi J. Effect of Membrane Tension on Gap Junctional Conductance of Supporting Cells in Corti's Organ. The Journal Of General Physiology 1998, 112: 447-455. PMID: 9758863, PMCID: PMC2229429, DOI: 10.1085/jgp.112.4.447.Peer-Reviewed Original ResearchConceptsTurgor pressureInner ear gap junctionsMembrane tensionPositive turgor pressureProtein kinase inhibitorsGap junctionsOsmotic pressure regulationPipette pressureSupporting cellsInner earMicroM HCochlear homeostasisGap junctional conductanceKinase inhibitorsMechanical forcesCell sizeJunctional conductance
1994
Cell coupling in the supporting cells of Corti's organ: Sensitivity to intracellular H+ and Ca+2
Sato Y, Santos-Sacchi J. Cell coupling in the supporting cells of Corti's organ: Sensitivity to intracellular H+ and Ca+2. Hearing Research 1994, 80: 21-24. PMID: 7852199, DOI: 10.1016/0378-5955(94)90004-3.Peer-Reviewed Original Research