2008
Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades
Nath AK, Brown RM, Michaud M, Sierra-Honigmann MR, Snyder M, Madri JA. Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades. Journal Of Cell Biology 2008, 181: 367-380. PMID: 18411306, PMCID: PMC2315681, DOI: 10.1083/jcb.200708197.Peer-Reviewed Original ResearchConceptsRepertoire of factorsEndocardial cushion formationMouse embryonic heartInterleukin-6 familyEmbryonic developmentCushion formationObserved phenotypeSignal transducerAlphavbeta3 integrin receptorTranscription 3Matrix metalloprotease-2Integrin receptorsMesenchymal transitionAlphavbeta3 integrinEmbryonic heartEMTAbnormal EMTMetalloprotease-2Functional inhibitionAktLoss of leptinPathwayVivo modelReceptorsInhibition
2004
A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels
Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW. A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels. Development 2004, 131: 5197-5209. PMID: 15459110, DOI: 10.1242/dev.01393.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transformationVEGFA levelsVentricular septal defectVascular endothelial growth factorDefective vasculogenesisEndothelial growth factorEndocardial cushionsInhibitor of VEGFVascular developmentTract abnormalitiesSeptal defectSFlt-1Right ventricleNormal liverVentral foregut endodermNormal cardiovascular developmentReceptor 1Abnormal cardiac developmentGrowth factorNull mutationVentral foregutAberrant developmentCompact myocardiumAV explantsE8.5-9.0