2014
Stratified control of IGF-I expression by hypoxia and stress hormones in osteoblasts
McCarthy TL, Yun Z, Madri JA, Centrella M. Stratified control of IGF-I expression by hypoxia and stress hormones in osteoblasts. Gene 2014, 539: 141-151. PMID: 24440782, PMCID: PMC4316208, DOI: 10.1016/j.gene.2014.01.011.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsCCAAT-Enhancer-Binding Protein-deltaCell HypoxiaCells, CulturedCore Binding Factor Alpha 1 SubunitDinoprostoneDNADNA ReplicationGene Expression RegulationHydrocortisoneInsulin-Like Growth Factor IOsteoblastsOxygenPromoter Regions, GeneticProtein BiosynthesisRatsRats, Sprague-DawleyRegulatory Elements, TranscriptionalRNA, MessengerConceptsIGF-I expressionStress hormonesIGF-I gene promoterIGF-I mRNAInfluence of PGE2Transcription factor C/EBPδOsteoblast transcription factor Runx2Hypoxic inhibitionI expressionPGE2Stimulatory effectGlucocorticoidsHypoxiaHIF activityHypoxic stressTranscription factor Runx2Bone cellsIGFProlonged exposureHormoneAlkaline phosphatase activitySystemic regulationOsteoblastsResponse elementRunx2
2007
Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis Overlap Associated With a Novel Mutation in Capillary Morphogenesis Protein-2 Gene
Antaya RJ, Cajaiba MM, Madri J, Lopez MA, Ramirez MC, Martignetti JA, Reyes-Múgica M. Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis Overlap Associated With a Novel Mutation in Capillary Morphogenesis Protein-2 Gene. American Journal Of Dermatopathology 2007, 29: 99-103. PMID: 17284973, DOI: 10.1097/01.dad.0000245636.39098.e5.Peer-Reviewed Original ResearchConceptsJuvenile hyaline fibromatosisInfantile systemic hyalinosisHyaline fibromatosisCapillary morphogenesis gene 2Painful skin lesionsImpairment of movementNovel mutationsVisceral involvementClinical pictureClinicopathologic findingsRare conditionSkin lesionsSystemic hyalinosisSubcutaneous tissueProtein 2 geneSevere disabilityGermline mutationsFibromatosisDiseaseAllelic diseasesGene 2Unclear natureMutationsHyalinosisLesions
2002
Transcription Factor Sp1 Phosphorylation Induced by Shear Stress Inhibits Membrane Type 1-Matrix Metalloproteinase Expression in Endothelium*
Yun S, Dardik A, Haga M, Yamashita A, Yamaguchi S, Koh Y, Madri JA, Sumpio BE. Transcription Factor Sp1 Phosphorylation Induced by Shear Stress Inhibits Membrane Type 1-Matrix Metalloproteinase Expression in Endothelium*. Journal Of Biological Chemistry 2002, 277: 34808-34814. PMID: 12093818, DOI: 10.1074/jbc.m205417200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCells, CulturedDNADNA-Binding ProteinsEarly Growth Response Protein 1Electrophoretic Mobility Shift AssayEndothelium, VascularImmediate-Early ProteinsMatrix Metalloproteinases, Membrane-AssociatedMetalloendopeptidasesNogalamycinPhosphorylationPromoter Regions, GeneticRatsRats, Sprague-DawleyRNA, MessengerSp1 Transcription FactorStress, PhysiologicalTranscription FactorsConceptsMT1-MMP expressionEgr-1MRNA transcriptionMT1-MMP promoterPost-translational modificationsCalf intestinal phosphataseDistinct environmental stimuliTranscription factor expressionSp1 phosphorylationEgr-1 expressionSp1 DNAEndothelial cell migrationSerine phosphorylationPromoter sitesSp1Cell migrationEnvironmental stimuliMatrix remodelingIntestinal phosphataseProtein levelsTranscriptionTime-dependent fashionPhosphorylationMechanical forcesExpression
1992
Platelet endothelial cell adhesion molecule, PECAM‐1, modulates cell migration
Schimmenti L, Yan H, Madri J, Albelda S. Platelet endothelial cell adhesion molecule, PECAM‐1, modulates cell migration. Journal Of Cellular Physiology 1992, 153: 417-428. PMID: 1429859, DOI: 10.1002/jcp.1041530222.Peer-Reviewed Original ResearchConceptsCell-cell adhesionCell-cell adhesion moleculesCell-cell contactPlatelet endothelial cell adhesion molecule-1Cell migrationIntegral membrane proteinsAdhesion moleculesPECAM-1 moleculesControl cellsCell surface adhesion moleculesModulates cell migrationNeomycin resistance geneEndothelial cell migrationMembrane proteinsCell adhesion moleculeEndothelial cellsExtracellular domainSurface adhesion moleculesNull cellsNIH/3T3 cellsResistance genesExtracellular matrixTransfectantsAdjacent cellsMigration assays
1990
Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance.
Kocher O, Kennedy S, Madri J. Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance. American Journal Of Pathology 1990, 137: 1509-24. PMID: 2260635, PMCID: PMC1877716.Peer-Reviewed Original ResearchConceptsAlternative splicingIIICS regionBovine aortic endothelial cellsHuman umbilical vein endothelial cell cDNA libraryRecombinant proteinsEndothelial cell cDNA libraryCell cDNA librarySpecific gene expressionSmooth muscle cellsAortic endothelial cellsEndothelial cellsMuscle cellsB16F10 melanoma cellsMelanoma cellsVascular cell functionCell attachmentFibronectin mRNACDNA clonesCDNA libraryRGDS sequenceGene expressionDNA fragmentsSplicingSequence analysisDifferent cell populations
1987
Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion
Ingber D, Madri J, Folkman J. Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion. In Vitro Cellular & Developmental Biology 1987, 23: 387-394. PMID: 2438264, DOI: 10.1007/bf02620997.Peer-Reviewed Original Research