2019
Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids
Boisvert EM, Means RE, Michaud M, Madri JA, Katz SG. Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids. Cell Death & Disease 2019, 10: 325. PMID: 30975982, PMCID: PMC6459920, DOI: 10.1038/s41419-019-1553-x.Peer-Reviewed Original ResearchConceptsNeonatal hypoxic injuryBrain developmentEfficacy of minocyclineLow birth weightUse of minocyclineEffects of hypoxiaNormal brain developmentCerebral organoid modelHuman brain organoidsLater time pointsAnimal model systemsNeonatal hypoxicDevastating causeCerebral palsySignificant morbidityHuman brain developmentNeurological consequencesBirth weightHypoxic injuryNeuronal deathCortical neuronsInjury resultsGlial cellsForebrain markersPotential treatment
2000
Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain
Ogunshola O, Stewart W, Mihalcik V, Solli T, Madri J, Ment L. Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain. Brain Research 2000, 119: 139-153. PMID: 10648880, DOI: 10.1016/s0165-3806(99)00125-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell CountCerebral CortexChronic DiseaseEndothelial Growth FactorsGene Expression Regulation, DevelopmentalGlial Fibrillary Acidic ProteinHypoxia, BrainLymphokinesMicrocirculationNeovascularization, PhysiologicNeurogliaNeuronsPlatelet Endothelial Cell Adhesion Molecule-1RatsRNA, MessengerVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factorLocalization of VEGFCortical neuronsGlial cellsNeuronal expressionChronic sublethal hypoxiaRat brain cortexAge-matched controlsCortical brain tissueHypoxia-driven angiogenesisPostnatal day 3Endothelial growth factorDensity of vesselsWestern blot analysisHypoxic animalsHypoxic chamberVascular bedNewborn ratsRat brainBrain cortexControl animalsDay 3High neuronal expressionSublethal hypoxiaPostnatal development