2001
pp60c-src Modulates Microvascular Endothelial Phenotype and in Vitro Angiogenesis
Marx M, Warren S, Madri J. pp60c-src Modulates Microvascular Endothelial Phenotype and in Vitro Angiogenesis. Experimental And Molecular Pathology 2001, 70: 201-213. PMID: 11417999, DOI: 10.1006/exmp.2001.2358.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBecaplerminCell DivisionEndothelium, VascularGenes, srcGenetic VectorsMaleMicrocirculationMoloney murine leukemia virusNeovascularization, PhysiologicPlatelet-Derived Growth FactorProto-Oncogene Proteins c-sisProto-Oncogene Proteins pp60(c-src)RatsRecombinant ProteinsSignal TransductionTransfectionConceptsC-Src mutantC-SrcTwo-dimensional cultureThree-dimensional cultureWild-type c-SrcC-Src kinase activityC-Src tyrosine kinaseC-Src associatesC-src proteinPlatelet-derived growth factor receptorV-SrcPDGF signalCytoskeletal organizationGrowth factor receptorKinase activityCell shapeTyrosine kinaseVitro AngiogenesisTube-like structuresCell morphologyFactor receptorTube formationMutantsRegulatory effectsOverexpression
1987
The Extracellular Matrix as a Modulator of Angiogenesis
Madri J. The Extracellular Matrix as a Modulator of Angiogenesis. Gwumc Department Of Biochemistry And Molecular Biology Annual Spring Symposia 1987, 177-183. DOI: 10.1007/978-1-4684-5296-9_21.Peer-Reviewed Original ResearchLarge vessel endothelial cellsEndothelial cell populationCell populationsExtracellular matrixEndothelial cellsHeterogeneous cell populationsEndothelial cell behaviorMicrovascular endothelial cellsMulticellular organizationCytoskeletal organizationProliferation rateSheet migrationModulators of angiogenesisMatrix organizationCell behaviorTransport functionMatrix compositionVessel endothelial cellsMatrix componentsMatrix synthesisCellsDiverse vascular bedsSeries of responsesDifferentiationMatrix determines