2018
Mental health and HIV: research priorities related to the implementation and scale up of ‘treat all’ in sub-Saharan Africa
Parcesepe AM, Bernard C, Agler R, Ross J, Yotebieng M, Bass J, Kwobah E, Adedimeji A, Goulet J, Althoff KN. Mental health and HIV: research priorities related to the implementation and scale up of ‘treat all’ in sub-Saharan Africa. Journal Of Virus Eradication 2018, 4: 16-25. PMID: 30515310, PMCID: PMC6248852, DOI: 10.1016/s2055-6640(20)30341-1.Peer-Reviewed Original ResearchHIV treatment outcomesAntiretroviral therapyMental healthTreatment outcomesMental illnessInternational epidemiology DatabasesMental health multimorbidityCD4 cell countHealth-related recommendationsWorld Health Organization guidelinesHealth Organization guidelinesImplementation science researchHIV careEpidemiology DatabaseSaharan AfricaAIDS (IeDEA) consortiumMental health researchHIVCell countEpidemiological researchOrganization guidelinesHealth researchResearch recommendationsIllnessIntervention research
2015
Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients
Weisberg DF, Gordon KS, Barry DT, Becker WC, Crystal S, Edelman EJ, Gaither J, Gordon AJ, Goulet J, Kerns RD, Moore BA, Tate J, Justice AC, Fiellin DA. Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 69: 223-233. PMID: 26009831, PMCID: PMC4446730, DOI: 10.1097/qai.0000000000000591.Peer-Reviewed Original ResearchConceptsLong-term opioidsMorphine equivalent daily doseOpioid receiptRisk of deathLong-term prescriptionUninfected patientsOpioid dosesAntiretroviral therapyHazard ratioDaily dosePropensity scoreHigher opioid dosesCause mortalityHIV statusAvailable patientsMortality riskOpioidsHIVPatientsProspective analysisMortalityBenzodiazepinesDosesDeathRiskHormonal contraceptive use in HIV-infected women using antiretroviral therapy: a systematic review
Womack JA, Novick G, Goulet JL. Hormonal contraceptive use in HIV-infected women using antiretroviral therapy: a systematic review. Open Access Journal Of Contraception 2015, Volume 6: 37-52. PMID: 28955156, PMCID: PMC5611808, DOI: 10.2147/oajc.s55038.Peer-Reviewed Original ResearchAntiretroviral therapyHormonal contraceptionSystematic reviewHormonal contraceptive useNewcastle-Ottawa ScaleManual reference checksElectronic literature searchEfficacy of contraceptionOutcomes of interestPharmacokinetic interactionsClinical outcomesFull-text versionHormonal contraceptivesContraceptive optionsContraceptive useMAIN OUTCOMEElectronic searchTherapyPotential articlesHIVLiterature searchContraceptionArticles of interestWomenOutcomes
2014
The VACS Index Accurately Predicts Mortality and Treatment Response among Multi-Drug Resistant HIV Infected Patients Participating in the Options in Management with Antiretrovirals (OPTIMA) Study
Brown ST, Tate JP, Kyriakides TC, Kirkwood KA, Holodniy M, Goulet JL, Angus BJ, Cameron DW, Justice AC, . The VACS Index Accurately Predicts Mortality and Treatment Response among Multi-Drug Resistant HIV Infected Patients Participating in the Options in Management with Antiretrovirals (OPTIMA) Study. PLOS ONE 2014, 9: e92606. PMID: 24667813, PMCID: PMC3965438, DOI: 10.1371/journal.pone.0092606.Peer-Reviewed Original ResearchConceptsVACS IndexCombination antiretroviral therapyNet reclassification improvementHIV biomarkersCause mortalityC-statisticTreatment interventionsMulti-drug resistant HIVHarrel's c-statisticsRespective hazard ratiosKaplan-Meier estimatesProportional hazards modelImproved scoresAntiretroviral studiesAntiretroviral therapyHazard ratioResistant HIVReclassification improvementRestricted IndexTreatment responseStudy interventionRisk scoreHazards modelVAC indexMortality
2012
Impact of Antiretroviral Therapy on Tuberculosis Incidence Among HIV-Positive Patients in High-Income Countries
del Amo J, Moreno S, Bucher HC, Furrer H, Logan R, Sterne J, Pérez-Hoyos S, Jarrín I, Phillips A, Lodi S, van Sighem A, de Wolf W, Sabin C, Bansi L, Justice A, Goulet J, Miró JM, Ferrer E, Meyer L, Seng R, Toulomi G, Gargalianos P, Costagliola D, Abgrall S, Hernán MA. Impact of Antiretroviral Therapy on Tuberculosis Incidence Among HIV-Positive Patients in High-Income Countries. Clinical Infectious Diseases 2012, 54: 1364-1372. PMID: 22460971, PMCID: PMC3404691, DOI: 10.1093/cid/cis203.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAnti-HIV AgentsCD4 Lymphocyte CountCohort StudiesDeveloped CountriesDrug Therapy, CombinationEuropeFemaleHIV InfectionsHIV SeropositivityHumansImmune Reconstitution Inflammatory SyndromeIncidenceMaleMiddle AgedMycobacterium tuberculosisPneumocystis cariniiPneumonia, PneumocystisRNA, ViralTuberculosisUnited StatesViral LoadConceptsImmune reconstitution inflammatory syndromeCD4 cell countCells/μL.HIV RNA levelsHazard ratioTuberculosis incidenceCART initiationCell countAntiretroviral therapyTime-varying CD4 cell countBaseline CD4 cell countAIDS-free individualsEffects of CARTLow tuberculosis incidenceMonths of ARTReconstitution inflammatory syndromeHIV-positive patientsRNA levelsHIV-positive individualsHuman immunodeficiency virusHIV-CAUSAL CollaborationInflammatory syndromeImmunodeficiency virusInverse probability weightingPositive individuals
2011
When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study.
Cain L, Logan R, Robins J, Sterne J, Sabin C, Bansi L, Justice A, Goulet J, van Sighem A, de Wolf F, Bucher H, von Wyl V, Esteve A, Casabona J, del Amo J, Moreno S, Seng R, Meyer L, Perez-Hoyos S, Muga R, Lodi S, Lanoy E, Costagliola D, Hernan M. When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. Annals Of Internal Medicine 2011, 154: 509-15. PMID: 21502648, PMCID: PMC3610527, DOI: 10.7326/0003-4819-154-8-201104190-00001.Peer-Reviewed Original ResearchConceptsCD4 cell countCombined end pointHazard ratioCell countCells/LAntiretroviral therapyCells/L.CD4 cell count thresholdBaseline CD4 cell countEnd pointVeterans Health Administration systemInitiation of cARTThreshold CD4 countCorresponding hazard ratiosMortality hazard ratioAIDS-free survivalProspective observational dataHIV-CAUSAL CollaborationMost clinical guidelinesHealth Administration systemUse of CD4Marginal structural modelsCell count thresholdCART initiationDynamic marginal structural models
2008
Quantifying the Decrement in Utility from Perceived Side Effects of Combination Antiretroviral Therapies in Patients with HIV
Braithwaite RS, Goulet J, Kudel I, Tsevat J, Justice AC. Quantifying the Decrement in Utility from Perceived Side Effects of Combination Antiretroviral Therapies in Patients with HIV. Value In Health 2008, 11: 975-979. PMID: 18225989, PMCID: PMC3121315, DOI: 10.1111/j.1524-4733.2007.00315.x.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyBothersome symptomsSF-6D utilitiesAntiretroviral therapyCD4 countSide effectsVeterans Aging Cohort StudyAging Cohort StudySF-12 scoresAfrican American raceHazardous alcohol consumptionQuality of lifeRecent drug useCART initiationMild anginaCohort studyMultivariable analysisCigarette smokingUnivariate analysisAmerican raceAlcohol consumptionDrug useUtility decrementsPatientsClinical decision
2007
Decreased Awareness of Current Smoking Among Health Care Providers of HIV-positive Compared to HIV-negative Veterans
Crothers K, Goulet JL, Rodriguez-Barradas MC, Gibert CL, Butt AA, Braithwaite RS, Peck R, Justice AC. Decreased Awareness of Current Smoking Among Health Care Providers of HIV-positive Compared to HIV-negative Veterans. Journal Of General Internal Medicine 2007, 22: 749-754. PMID: 17503106, PMCID: PMC2219870, DOI: 10.1007/s11606-007-0158-8.Peer-Reviewed Original ResearchConceptsHIV providersCurrent smokingSmoking cessationCough/dyspneaHIV-negative patientsHIV-negative veteransCombination antiretroviral therapyHIV-positive patientsHIV viral suppressionPatient's HIV statusImportant risk factorHealth care providersElectronic medical recordsBackgroundCigarette smokingAntiretroviral therapyComorbid illnessesViral suppressionComorbid diseasesCurrent smokersIndependent predictorsProvider questionnairesHIV statusVA databasesPatient populationImmune competence
2006
Association of Comorbidity with Physical Disability in Older HIV-Infected Adults
Oursler KK, Goulet JL, Leaf DA, Akingicil A, Katzel LI, Justice A, Crystal S. Association of Comorbidity with Physical Disability in Older HIV-Infected Adults. AIDS Patient Care And STDs 2006, 20: 782-791. PMID: 17134352, DOI: 10.1089/apc.2006.20.782.Peer-Reviewed Original ResearchConceptsHIV-negative patientsPhysical functioningComorbid conditionsVeterans Aging Cohort StudyGeneral medical comorbidityHIV medical careHIV-negative veteransRelationship of comorbiditiesHIV disease stageHIV-negative subjectsAssociation of comorbiditiesChronic lung diseaseAging Cohort StudyCoronary artery diseaseYears of ageSelf-reported difficultyOlder HIVAntiretroviral therapyMedical comorbiditiesCohort studyArtery diseaseClinical factorsPatient groupDisease stageLung disease
2005
Differences between Infectious Diseases—Certified Physicians and General Medicine—Certified Physicians in the Level of Comfort with Providing Primary Care to Patients
Fultz SL, Goulet JL, Weissman S, Rimland D, Leaf D, Gibert C, Rodriguez-Barradas MC, Justice AC. Differences between Infectious Diseases—Certified Physicians and General Medicine—Certified Physicians in the Level of Comfort with Providing Primary Care to Patients. Clinical Infectious Diseases 2005, 41: 738-743. PMID: 16080098, DOI: 10.1086/432621.Peer-Reviewed Original ResearchConceptsID clinicComorbid conditionsActive antiretroviral therapyInfectious disease clinicCommon comorbid conditionsHuman immunodeficiency virusGeneral medical clinicLevel of comfortAntiretroviral therapyComorbid diseasesDisease clinicSuch patientsSelf-reported comfortImmunodeficiency virusPrimary careHIV medicinePrescribing medicationsSubstantial prevalencePatientsPhysician levelClinicMedical clinicsGeneralist physiciansHypertensionHyperlipidemia
2000
HIV as a chronic disease: Implications for long-term care at an AIDS-dedicated skilled nursing facility
Selwyn P, Goulet J, Molde S, Constantino J, Fennie K, Wetherill P, Gaughan D, Brett-Smith H, Kennedy C. HIV as a chronic disease: Implications for long-term care at an AIDS-dedicated skilled nursing facility. Journal Of Urban Health 2000, 77: 187-203. PMID: 10856000, PMCID: PMC3456125, DOI: 10.1007/bf02390530.Peer-Reviewed Original ResearchConceptsSkilled nursing facilitiesLong-term careNursing facilitiesPsychiatric illnessNeurologic diseaseTerminal careChronic disease phaseComparison of admissionMedian Karnofsky scoreLong-term care facilitiesCurrent antiretroviral therapyLength of stayInjection drug usersYear of admissionSerious neurologic diseaseAcute medical treatmentLevel of careAdmission medicationsMedian CD4Advanced diseaseAntiretroviral therapyImportant service needsKarnofsky scoreChart reviewImmunodeficiency syndrome