1996
Protective antibodies in murine Lyme disease arise independently of CD40 ligand.
Fikrig E, Barthold SW, Chen M, Grewal IS, Craft J, Flavell RA. Protective antibodies in murine Lyme disease arise independently of CD40 ligand. The Journal Of Immunology 1996, 157: 1-3. PMID: 8683101, DOI: 10.4049/jimmunol.157.1.1.Peer-Reviewed Original ResearchConceptsCD40L-deficient miceCD40 ligand-deficient miceMurine Lyme diseaseRegression of arthritisTransfer of serumDependent immune responsesIgG2b AbsAcute arthritisControl miceProtective antibodiesIg class switchingCD40 ligandImmune responseImmunodeficient miceLyme borreliosisLyme diseaseMiceBorrelia burgdorferiB. burgdorferiClass switchingArthritisBurgdorferiAbInfectionDisease
1995
Safety and Immunogenicity of an Outer Surface Protein A Vaccine in Subjects with Previous Lyme Disease
Schoen R, Meurice F, Brunet C, Cretella S, Krause D, Craft J, Fikrig E. Safety and Immunogenicity of an Outer Surface Protein A Vaccine in Subjects with Previous Lyme Disease. The Journal Of Infectious Diseases 1995, 172: 1324-1329. PMID: 7594671, DOI: 10.1093/infdis/172.5.1324.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, BacterialAntibody FormationAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayHumansImmunization ScheduleImmunoglobulin GLipoproteinsLyme DiseaseProspective StudiesSafetyVaccines, SyntheticConceptsSide effectsLyme diseaseOspA vaccinePrevious Lyme diseaseThree-dose scheduleLocal side effectsSystemic side effectsLyme vaccineMild arthralgiaVaccine doseThird doseProspective studyOspA antibodiesHealthy volunteersOuter surface proteinsVaccinePatientsDiseaseImmunogenicityDoseMonthsSubjectsSurface proteinsSafetyArthralgia
1992
Prevention of Lyme Disease after Tick Bites
Magid D, Schwartz B, Craft J, Schwartz J. Prevention of Lyme Disease after Tick Bites. New England Journal Of Medicine 1992, 327: 534-541. PMID: 1298217, DOI: 10.1056/nejm199208203270806.Peer-Reviewed Original ResearchConceptsTick biteProbability of infectionLyme diseaseOnly patientsEmpirical therapyErythema migransEmpirical treatmentBurgdorferi infectionAdditional minor complicationsMost major complicationsWeeks of doxycyclinePositive serologic testsDisease one monthEndemic Lyme diseaseBorrelia burgdorferi infectionB. burgdorferi infectionAdverse eventsMinor complicationsMost complicationsMajor complicationsEarly treatmentSerologic testsPatientsComplicationsInfection