2022
Rare Presentation of Rosai‐Dorfman Disease in Soft Tissue: Diagnostic Findings and Surgical Treatment
Betini N, Munger AM, Rottmann D, Haims A, Costa J, Lindskog DM. Rare Presentation of Rosai‐Dorfman Disease in Soft Tissue: Diagnostic Findings and Surgical Treatment. Case Reports In Surgery 2022, 2022: 8440836. PMID: 35402057, PMCID: PMC8986417, DOI: 10.1155/2022/8440836.Peer-Reviewed Original ResearchSoft tissue Rosai-Dorfman diseaseRosai-Dorfman diseaseExtranodal sitesPlasma cellsNodal Rosai-Dorfman diseaseExtranodal Rosai-Dorfman diseaseEmperipolesis of lymphocytesOrthopedic oncology clinicSoft tissueMinority of casesRDD cellsAssociated lymphadenopathyLymphoplasmacytic infiltrationLymph nodesMixed infiltratePathologic reviewSurgical treatmentOncology clinicChief complaintRare presentationMononuclear cellsSkin changesTreatment paradigmDiagnostic findingsLumbosacral mass
2021
Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and Telomeres
Wang H, Gong P, Chen T, Gao S, Wu Z, Wang X, Li J, Marjani SL, Costa J, Weissman SM, Qi F, Pan X, Liu L. Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and Telomeres. Advanced Science 2021, 8: 2004320. PMID: 33898197, PMCID: PMC8061397, DOI: 10.1002/advs.202004320.Peer-Reviewed Original ResearchConceptsCancer stem cellsCancer epithelial cellsTumor-initiating cellsCancer stem cell stateEpithelial cellsStem cell stateStem cellsRare cancer stem cellsSimultaneous single-cell analysisHeterogeneity of CSCsSingle-cell analysisNumber variation patternsHippo/YAPDepth transcriptomeSmart-seq2Phylogenetic relationshipsNormal stem cellsCell statesNonproliferative natureColorectal cancerDisplay plasticityDormant stateShort telomeresTelomerase activityTranscriptome
2020
The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights
Sasaki CT, Doukas SG, Costa J, Vageli DP. The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights. Cancers 2020, 12: 1064. PMID: 32344873, PMCID: PMC7281001, DOI: 10.3390/cancers12051064.Peer-Reviewed Original ResearchAcidic bileUpper aerodigestive tractAdditional risk factorsBiomarkers of progressionSquamous cell carcinogenesisNF-κB activationNeck malignanciesAerodigestive tractInvasive cancerHistopathological changesRisk factorsHypopharyngeal mucosaEarly neoplasiaMalignant lesionsP53 expressionTranslational studiesVivo modelCell carcinogenesisBileExperimental modelEarly detectionCancerNovel evidenceMutagenic effectsFirst studySynovial Myxoma: Found in Canines, Rabbits, and Now Humans Too?: A Case Report.
Munger AM, Ibe IK, Rottmann D, Conway D, Costa J, Lindskog DM. Synovial Myxoma: Found in Canines, Rabbits, and Now Humans Too?: A Case Report. JBJS Case Connector 2020, 10: e0490. PMID: 32224675, DOI: 10.2106/jbjs.cc.19.00490.Peer-Reviewed Case Reports and Technical NotesConceptsSynovial myxomaCase reportRight knee painYear old womanCluster of differentiationLow proliferative activityAggressive massKnee painPathologic reviewIntralesional resectionArthroscopic synovectomyKnee aspirationSynovial cellsInfiltrative tumorsMyxoid stromaProliferative activityPainSynovectomyMyxomaSlow growingReportResectionPatientsEffusionHumans
2019
Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications
Sasaki CT, Doukas SG, Costa J, Vageli DP. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications. Cancer 2019, 125: 3554-3565. PMID: 31310330, DOI: 10.1002/cncr.32369.Peer-Reviewed Original ResearchConceptsHuman hypopharyngeal squamous cell carcinomaAdjacent normal tissuesIL-6Reflux diseaseHypopharyngeal squamous cell carcinomaMiR-375Respective adjacent normal tissuesMiR-21Pilot studyEsophageal reflux diseaseIndependent risk factorNew clinical evidenceSquamous cell carcinomaOncomiR miR-21NF-κB activationMiR-21/miRTumor suppressor miR-375Quantitative polymerase chain reactionMessenger RNABiliary refluxHypopharyngeal carcinogenesisControl patientsLaryngopharyngeal refluxClinical evidenceHypopharyngeal carcinoma
2018
Predictors of Lymph Node Involvement by Soft Tissue Sarcoma: An Analysis of the National Cancer Database (NCDB)
Miccio J, Jairam V, Gao S, Augustyn A, Oladeru O, Onderdonk B, Costa J, Han D, Khan S, Friedlaender G, Lindskog D, Deshpande H, Tara H, Osborn H, Roberts K, Patel K. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma: An Analysis of the National Cancer Database (NCDB). International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e335. DOI: 10.1016/j.ijrobp.2018.07.1028.Peer-Reviewed Original ResearchA brave new world
Costa J. A brave new world. Virchows Archiv 2018, 473: 141-144. PMID: 29569207, DOI: 10.1007/s00428-018-2338-9.Peer-Reviewed Original Research
2017
A 49-Year-Old Man with Subacute Respiratory Failure and Interstitial Lung Opacities
Rudkovskaia AA, Lo YC, Brady V, Costa J, Fares WH. A 49-Year-Old Man with Subacute Respiratory Failure and Interstitial Lung Opacities. American Journal Of Case Reports 2017, 18: 941-944. PMID: 28855497, PMCID: PMC5590515, DOI: 10.12659/ajcr.903742.Peer-Reviewed Original ResearchConceptsPulmonary tumor thrombotic microangiopathyRight heart catheterizationPulmonary arterial hypertensionTrans-bronchial biopsyPulmonary hypertensionDiagnosis of PTTMPulseless electrical activity cardiac arrestBackground Pulmonary arterial hypertensionGastro-esophageal junction adenocarcinomaNew bilateral pulmonary infiltratesInitiation of trastuzumabMicroscopic tumor embolismSubacute respiratory failureTrans-thoracic echocardiogramTumor thrombotic microangiopathyBilateral pulmonary infiltratesSevere pulmonary hypertensionComplaints of coughRV systolic functionShortness of breathComputed tomography angiographySmall pulmonary vesselsSmooth muscle proliferationPulmonary infiltratesArterial hypertension
2016
Metastatic Papillary Thyroid Carcinoma with Multifocal Synchronous Transformation to Anaplastic Thyroid Carcinoma.
Benedict M, Costa J. Metastatic Papillary Thyroid Carcinoma with Multifocal Synchronous Transformation to Anaplastic Thyroid Carcinoma. Case Reports In Pathology 2016, 2016: 4863405. PMID: 27774331, PMCID: PMC5059640, DOI: 10.1155/2016/4863405.Peer-Reviewed Original Research
2014
Genetic alterations in chondrosarcomas – keys to targeted therapies?
Samuel AM, Costa J, Lindskog DM. Genetic alterations in chondrosarcomas – keys to targeted therapies? Cellular Oncology 2014, 37: 95-105. PMID: 24458248, DOI: 10.1007/s13402-014-0166-8.Peer-Reviewed Original ResearchConceptsBenign cartilaginous lesionsCartilaginous lesionsMalignant transformationIhh/PTHrPTwo-hit scenarioPrimary bone tumorsGenetic alterationsDruggable molecular targetsKey genetic alterationsHuman tumor typesResultsCurrent dataBone tumorsMalignant tumorsSarcoma typesMalignant chondrosarcomasKey molecular changesNormal cell cycle controlTumor typesMalignant cellsChondrosarcoma developmentLesionsMolecular targetsTumorsEarly-stage eventsDifferentiation of chondrocytes
2012
Systems Pathology
Costa J, Donovan M. Systems Pathology. 2012, 197-207. DOI: 10.1007/978-1-4614-4800-6_8.Peer-Reviewed Original ResearchAccessible knowledge baseArtificial intelligenceDiagnostic analyticsComplex systems scienceKnowledge baseAgnostic approachHigh-density dataLarge volumesSystem levelSystems scienceNew rulesAnalyticsIntelligenceNovel technologySystem pathologySpecific clinical caseTechnologyVariety of venuesIntegrationRulesDataTherapeutic problemsPreclinical studiesMutational load distribution analysis of colorectal and pancreatic carcinoma by next generation sequencing platform.
Lopez-Doriga A, Azuara D, Morell M, de Oca J, Rodriguez-Moranta F, Fabregat J, Boadas J, Larochelle W, Capella G, Costa J. Mutational load distribution analysis of colorectal and pancreatic carcinoma by next generation sequencing platform. Journal Of Clinical Oncology 2012, 30: 57-57. DOI: 10.1200/jco.2012.30.30_suppl.57.Peer-Reviewed Original Research
2011
Evidence-Based Pathology: A Stable Set of Principles for a Rapidly Evolving Specialty
Costa J, Whitaker S. Evidence-Based Pathology: A Stable Set of Principles for a Rapidly Evolving Specialty. 2011, 19-25. DOI: 10.1007/978-1-4419-1030-1_2.Peer-Reviewed Original Research
2010
Personalized approach to prostate cancer prognosis.
Donovan M, Costa J, Cordon-Cardo C. Personalized approach to prostate cancer prognosis. Minerva Urologica E Nefrologica 2010, 62: 231-9. PMID: 20940693.Peer-Reviewed Original ResearchConceptsProstate-specific antigenProstate needle biopsyNeedle biopsyProstate cancerProstatectomy specimenDiagnostic prostate needle biopsiesSerum prostate-specific antigenPatient-specific risk profileClinical-pathologic variablesExtent of diseaseManagement of patientsAncillary diagnostic studiesTreatment decision processPrognostic featuresTumor differentiationBreast cancerIndividual patientsCancer prognosisSpecific antigenClinical judgmentHealth outcomesMost urologistsTumor typesClinical decisionPatient attributesMontebello: A Metapopulation Based Model of Carcinogenesis
Tuck D, Miranker W, Costa J. Montebello: A Metapopulation Based Model of Carcinogenesis. Lecture Notes In Computer Science 2010, 6350: 173-176. DOI: 10.1007/978-3-642-15979-4_19.Peer-Reviewed Original Research
2009
Employing multiplex immunofluorescence to quantify Her2 and phosphorylated Her2 in formalin-fixed, paraffin-embedded breast tumor specimens
Donovan M, Puig P, Erill N, Clayton M, Hamann S, Khan F, Powell D, Costa J, Cordon-Cardo C, Baselga J. Employing multiplex immunofluorescence to quantify Her2 and phosphorylated Her2 in formalin-fixed, paraffin-embedded breast tumor specimens. Breast Cancer Research 2009, 11: p30. PMCID: PMC4284916, DOI: 10.1186/bcr2313.Peer-Reviewed Original ResearchPREDICTION OF DISEASE PROGRESSION INCLUDING DURABLE RESPONSE TO HORMONAL THERAPY AT DIAGNOSIS, USING THE PROSTATE NEEDLE BIOPSY AND PRETREATMENT CLINICAL VARIABLES
Donovan M, Khan F, Fernandez G, Mesa-Tejada R, Sapir M, Bayer-Zubek V, Fogarsi S, Vengrenyuk Y, Teverovskiy M, Karnes R, Gaffey T, Busch C, Freedland S, Albertsen P, Costa J, Cordon-Cardo C. PREDICTION OF DISEASE PROGRESSION INCLUDING DURABLE RESPONSE TO HORMONAL THERAPY AT DIAGNOSIS, USING THE PROSTATE NEEDLE BIOPSY AND PRETREATMENT CLINICAL VARIABLES. Journal Of Urology 2009, 181: 771. DOI: 10.1016/s0022-5347(09)62147-9.Peer-Reviewed Original Research
2008
NIH consensus development statement on management of hepatitis B.
Belongia E, Costa J, Gareen I, Grem J, Inadomi J, Kern E, McHugh J, Petersen G, Rein M, Sorrell M, Strader D, Trotter H. NIH consensus development statement on management of hepatitis B. NIH Consensus And State-of-the-Science Statements 2008, 25: 1-29. PMID: 18949020.Peer-Reviewed Original ResearchConceptsAnti-HBV therapyHBV DNAHepatocellular carcinomaChronic HBVALT levelsHepatitis BHepatitis B.Advanced fibrosisLiver failureHBV genotype C infectionRepresentative prospective cohort studyElevated HBV DNAHBV prevalence rateImmune active phaseImmune-tolerant phaseLatent HBV infectionLiver-specific mortalityLow replicative phaseChronic hepatitis BPlacebo-controlled trialProspective cohort studyGenotype C infectionAcute liver failureClinical health outcomesBurden of disease
2006
Spatial Dynamics in Cancer
Solé R, González García I, Costa J. Spatial Dynamics in Cancer. Topics In Biomedical Engineering. International Book Series 2006, 557-572. DOI: 10.1007/978-0-387-33532-2_24.Peer-Reviewed Original Research
2002
Semireannealing, Single-Stranded Conformational Polymorphism: A Novel and Effective Tool for the Diagnosis of T-Cell Clonality
Crisi G, Emanuel J, Johnson C, Crotty P, Costa J, Tallini G. Semireannealing, Single-Stranded Conformational Polymorphism: A Novel and Effective Tool for the Diagnosis of T-Cell Clonality. Applied Immunohistochemistry & Molecular Morphology 2002, 11: 67-74. PMID: 12045709, DOI: 10.1097/00019606-200206000-00002.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceClone CellsDNA, NeoplasmElectrophoresis, CapillaryElectrophoresis, Polyacrylamide GelGene RearrangementHumansLymph NodesLymphoma, B-CellLymphoma, T-CellMolecular Sequence DataNucleic Acid ConformationPolymerase Chain ReactionPolymorphism, Single-Stranded ConformationalPseudolymphomaReceptors, Antigen, T-Cell, gamma-deltaSequence AlignmentSequence Analysis, DNA