2019
Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications
Sasaki CT, Doukas SG, Costa J, Vageli DP. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications. Cancer 2019, 125: 3554-3565. PMID: 31310330, DOI: 10.1002/cncr.32369.Peer-Reviewed Original ResearchConceptsHuman hypopharyngeal squamous cell carcinomaAdjacent normal tissuesIL-6Reflux diseaseHypopharyngeal squamous cell carcinomaMiR-375Respective adjacent normal tissuesMiR-21Pilot studyEsophageal reflux diseaseIndependent risk factorNew clinical evidenceSquamous cell carcinomaOncomiR miR-21NF-κB activationMiR-21/miRTumor suppressor miR-375Quantitative polymerase chain reactionMessenger RNABiliary refluxHypopharyngeal carcinogenesisControl patientsLaryngopharyngeal refluxClinical evidenceHypopharyngeal carcinoma
1998
The Molecular Biology of Breast Cancer: Accelerating Clinical Applications
Dillon D, Howe C, Bosari S, Costa J. The Molecular Biology of Breast Cancer: Accelerating Clinical Applications. Critical Reviews™ In Oncogenesis 1998, 9: 125-140. PMID: 9973246, DOI: 10.1615/critrevoncog.v9.i2.30.Peer-Reviewed Original ResearchConceptsBreast cancerClinical applicationPreclinical disease modelsRegional oncology networkMolecular eventsOncology NetworkPractice guidelinesBRCA-1BRCA-2CancerGrowth factorTranslational researchDisease modelsPathogenesisCell deathBasic scienceCell cycle controlMetastasisClinicTherapyCycle controlMolecular biologyAbnormalitiesDiagnosis
1996
Detection of rare circulating human colon tumor cells in a nude mouse xenograft model
Pages J, Sordat B, Bautista D, Costa J, Benhattar J. Detection of rare circulating human colon tumor cells in a nude mouse xenograft model. Cancer Letters 1996, 106: 139-144. PMID: 8827058, DOI: 10.1016/0304-3835(96)04319-4.Peer-Reviewed Original ResearchConceptsHuman colon tumor cellsTumor cellsColon tumor cellsSensitive allele-specific polymerase chain reactionExperimental modelNude mouse xenograft modelK-ras mutationsMouse xenograft modelAllele-specific polymerase chain reactionK-ras geneLymph nodesPrimary implantationSpecific polymerase chain reactionHuman colon carcinoma cellsMicrometastatic depositsPolymerase chain reactionColon carcinoma cellsXenograft modelNude miceGAT mutationMetastatic processCarcinoma cellsBloodChain reactionOccurrence of cells
1985
Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors
Knazek R, Yee C, Costa J. Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors. International Journal Of Cancer 1985, 36: 143-152. PMID: 2991146, DOI: 10.1002/ijc.2910360204.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachidonic AcidArachidonic AcidsChondrosarcomaChromatography, High Pressure LiquidChromatography, Thin LayerHistiocytoma, Benign FibrousHumansHydroxyeicosatetraenoic AcidsMiceMice, NudeNeoplasm TransplantationProstaglandinsRadioimmunoassayRhabdomyosarcomaSarcomaSarcoma, SynovialSoft Tissue NeoplasmsTeratomaConceptsArachidonic acid metabolitesAcid metabolitesSynovial cell sarcomaSame histological typeMalignant fibrous histiocytomaTotal prostaglandin synthesisHydroxyeicosatetraenoic acid synthesisHuman mesenchymal tumorsMesenchymal tumor cellsHistological typeMesenchymal tumorsPGF2 alphaFibrous histiocytomaThromboxane A2Embryonal carcinomaNude miceProstaglandin synthesisPGE2 synthesisTransplantable tumorsAlveolar rhabdomyosarcomaTumorsStromal cellsArachidonic acidNormal tissuesTumor cells
1983
Murine Type C Retroviruses and Intracisternal A-Particles in Human Tumors Serially Passaged in Nude Mice2
Tralka T, Yee C, Rabson A, Wivel N, Stromberg K, Rabson A, Costa J. Murine Type C Retroviruses and Intracisternal A-Particles in Human Tumors Serially Passaged in Nude Mice2. Journal Of The National Cancer Institute 1983, 71: 591-599. PMID: 6310201, DOI: 10.1093/jnci/71.3.591.Peer-Reviewed Original ResearchConceptsType C virus particlesC virus particlesHuman osteosarcoma cellsNude miceHuman tumorsType C virus productionC virus infectionOsteosarcoma cellsStromal cell componentsVirus particlesType C virusesMurine type C retrovirusesC virusHLA determinantsVirus infectionHuman tumor cellsEmbryonal carcinomaType C retrovirusesHuman cellsNucleic acid hybridization studiesTumor cellsMurine leukemia virusTumorsVirus productionMice“Low grade” mucoepidermoid carcinoma of the bronchus with “high grade” biological behavior
Barsky S, Martin S, Matthews M, Gazdar A, Costa J. “Low grade” mucoepidermoid carcinoma of the bronchus with “high grade” biological behavior. Cancer 1983, 51: 1505-1509. PMID: 6825057, DOI: 10.1002/1097-0142(19830415)51:8<1505::aid-cncr2820510825>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsLow-grade histologic featuresMucoepidermoid carcinomaWidespread metastasesHistologic featuresBiological behaviorLow-grade mucoepidermoid carcinomaPrimary endobronchial tumorsHigh-grade lesionsLow-grade lesionsAggressive biological behaviorGrade mucoepidermoid carcinomaNumerous goblet cellsLow gradeGlycogen-rich cellsEndobronchial massEndobronchial tumorPrimary tumorMonomorphic cellsOriginal tumorMorphologic patternsNude miceGoblet cellsCarcinomaSubcutaneous tissueMetastasis
1982
Unusual Intranuclear Inclusions in Malignant Fibrous Histiocytoma: Presence in Primary Tumor
Tralka T, Yee C, Triche T, Costa J, Dienes H. Unusual Intranuclear Inclusions in Malignant Fibrous Histiocytoma: Presence in Primary Tumor. Ultrastructural Pathology 1982, 3: 161-167. PMID: 6285572, DOI: 10.3109/01913128209016640.Peer-Reviewed Original Research
1981
Synthesis of pro-collagen type II by a xenotransplanted human chondroblastic osteosarcoma.
Lanzer W, Liotta L, Yee C, Azar H, Costa J. Synthesis of pro-collagen type II by a xenotransplanted human chondroblastic osteosarcoma. American Journal Of Pathology 1981, 104: 217-26. PMID: 6945812, PMCID: PMC1903789.Peer-Reviewed Original Research
1977
Oncogenicity of a Nude Mouse Cell Line Transformed by a Human Papovavirus
Costa J, Howley P, Legallais F, Yee C, Young N, Rabson A. Oncogenicity of a Nude Mouse Cell Line Transformed by a Human Papovavirus. Journal Of The National Cancer Institute 1977, 58: 1147-1149. PMID: 557569, DOI: 10.1093/jnci/58.4.1147.Peer-Reviewed Original ResearchSpontaneous Lymphosarcoma Arising in a Nude Mouse: Characterization In Vivo and In Vitro
Tralka T, Costa J, Sindelar W, Rabson A, Gullino P, Henson E, Chu E, O'Conor G. Spontaneous Lymphosarcoma Arising in a Nude Mouse: Characterization In Vivo and In Vitro. Journal Of The National Cancer Institute 1977, 58: 977-982. PMID: 191631, DOI: 10.1093/jnci/58.4.977.Peer-Reviewed Original Research
1974
Effect of dexamethasone on herpes simplex virus type 2 infection in vitro
COSTA J, YEE C, TROOST T, RABSON A. Effect of dexamethasone on herpes simplex virus type 2 infection in vitro. Nature 1974, 252: 745-746. PMID: 4373659, DOI: 10.1038/252745a0.Peer-Reviewed Original ResearchConceptsHSV-2 infectionHerpes simplex virus type 2 infectionSimplex virus type 2 infectionVirus type 2 infectionEffect of corticosteroidsSimplex type 2Type 2 infectionEffect of dexamethasoneMouse mammary tumorsPresence of steroidsGlucocorticoid influencesEpidemiological evidenceMammary tumorsPhysiological dosesVirus-infected culturesType 2Plaque formationMalignant transformationViral strainsInfectionTypes of cellsMurine leukemia virusMouse embryo fibroblastsCorticosteroidsLeukemia virus