2014
Genetic alterations in chondrosarcomas – keys to targeted therapies?
Samuel AM, Costa J, Lindskog DM. Genetic alterations in chondrosarcomas – keys to targeted therapies? Cellular Oncology 2014, 37: 95-105. PMID: 24458248, DOI: 10.1007/s13402-014-0166-8.Peer-Reviewed Original ResearchConceptsBenign cartilaginous lesionsCartilaginous lesionsMalignant transformationIhh/PTHrPTwo-hit scenarioPrimary bone tumorsGenetic alterationsDruggable molecular targetsKey genetic alterationsHuman tumor typesResultsCurrent dataBone tumorsMalignant tumorsSarcoma typesMalignant chondrosarcomasKey molecular changesNormal cell cycle controlTumor typesMalignant cellsChondrosarcoma developmentLesionsMolecular targetsTumorsEarly-stage eventsDifferentiation of chondrocytes
1982
Small‐cell osteosarcoma
Martin S, Dwyer A, Kissane J, Costa J. Small‐cell osteosarcoma. Cancer 1982, 50: 990-996. PMID: 6953993, DOI: 10.1002/1097-0142(19820901)50:5<990::aid-cncr2820500529>3.0.co;2-r.Peer-Reviewed Original ResearchConceptsSmall cell osteosarcomaAdjuvant chemotherapyEwing's sarcomaEvidence of diseaseSymptoms of painForms of osteosarcomaClinical featuresOptimal therapyMonths durationRadiographic appearanceSarcomaTumorsRound cellsPatientsOsteoid matrixOsteosarcomaChemotherapyReceived radiationWide variationPainSurgeryTherapyLesionsSymptomsIncidence
1978
Osteosarcoma associated with thorotrast administration. Report of two cases and literature review
Sindelar W, Costa J, Ketcham A. Osteosarcoma associated with thorotrast administration. Report of two cases and literature review. Cancer 1978, 42: 2604-2609. PMID: 365315, DOI: 10.1002/1097-0142(197812)42:6<2604::aid-cncr2820420615>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsCases of osteosarcomaPathologic evidencePrimary tumorThorotrast depositsPossible causal relationshipReticuloendothelial systemOsteosarcomaPrevious casesChronic radiationPatientsNeoplastic transformationAdministrationBoneLiterature reviewAngiographyCausal relationshipHistologyTumorsThorotrastCases