1983
Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities
Rosenberg S, Tepper J, Glatstein E, Costa J, Young R, Baker A, Brennan M, Demoss E, Seipp C, Sindelar W, Sugarbaker P, Wesley R. Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities. Cancer 1983, 52: 424-434. PMID: 6344981, DOI: 10.1002/1097-0142(19830801)52:3<424::aid-cncr2820520307>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasDisease-free survivalAdjuvant chemotherapyChemotherapy groupOverall survivalTissue sarcomasPilot trialPatient groupRadiation therapyHigh-grade soft tissue sarcomasContinuous disease-free survivalLocal failureHigh-dose methotrexatePercent of patientsLimb-sparing surgeryImmediate postoperative periodProspective Randomized EvaluationWide local resectionPrevious pilot trialUnderwent amputationAdult patientsLocal resectionPostoperative periodLocal therapyActuarial analysis
1982
The Treatment of Soft-tissue Sarcomas of the Extremities
ROSENBERG S, TEPPER J, GLATSTEIN E, COSTA J, BAKER A, BRENNAM M, DEMOSS E, SEIPP C, SINDELAR W, SUGARBAKER P, WESLEY R. The Treatment of Soft-tissue Sarcomas of the Extremities. Annals Of Surgery 1982, 196: 305-315. PMID: 7114936, PMCID: PMC1352604, DOI: 10.1097/00000658-198209000-00009.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasHigh-grade soft tissue sarcomasLimb-sparing groupLimb-sparing resectionLocal recurrencePostoperative chemotherapyAdult patientsTissue sarcomasRadiation therapySurvival rateDisease-free survival ratesAdjuvant radiation therapyHigh-dose methotrexateLimb-sparing surgeryOverall survival rateProspective Randomized StudyWide local excisionJoint proximalAdjuvant chemotherapyResection groupPostoperative radiotherapyOverall survivalRandomized studyLocal excisionAmputation group