2007
Functional Circuitry for Peripheral Suppression in Mammalian Y-Type Retinal Ganglion Cells
Zaghloul KA, Manookin MB, Borghuis BG, Boahen K, Demb JB. Functional Circuitry for Peripheral Suppression in Mammalian Y-Type Retinal Ganglion Cells. Journal Of Neurophysiology 2007, 97: 4327-4340. PMID: 17460102, DOI: 10.1152/jn.01091.2006.Peer-Reviewed Original ResearchConceptsAmacrine cellsGanglion cellsCenter responseSynaptic layersY-type retinal ganglion cellsHorizontal cellsY-type ganglion cellsSecond synaptic layerGanglion cell receptive fieldsRetinal ganglion cellsGuinea pig retinaStimulus-response curvesRetinal ganglion cell receptive fieldsFirst synaptic layerCurrent-clamp conditionsBipolar terminalsGlutamate releaseCell receptive fieldsPeripheral gratingsPeripheral suppressionIntracellular recordingsPig retinaSubthreshold membrane potentialsExcitatory centerInhibitory conductance
2005
Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells
Zaghloul KA, Boahen K, Demb JB. Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells. Journal Of Neuroscience 2005, 25: 860-868. PMID: 15673666, PMCID: PMC6725633, DOI: 10.1523/jneurosci.2782-04.2005.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsIntracellular recordingsSubthreshold responsesY-type retinal ganglion cellsY-type ganglion cellsSynaptic mechanismsSynaptic inputsMammalian retinaSpiking responseExtracellular recordingsSubthreshold potentialsContrast sensitivitySpike outputSpike thresholdContrast adaptationSpike generationGain changesCellsRecordingsResponseApparent reductionRecording conditionsAbove effectsMean light level
2004
How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output
Demb JB, Sterling P, Freed MA. How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output. Journal Of Neurophysiology 2004, 92: 2510-2519. PMID: 15175375, DOI: 10.1152/jn.00108.2004.Peer-Reviewed Original ResearchConceptsSynaptic convergenceSpike outputGanglion cellsIntracellular recordingsSynaptic inputsSpike responsesF1 responseRetinal ganglion cellsSpike rateNeuron synaptic inputsPrimary visual cortexExtracellular recordingsVisual cortexPeak depolarizationStimulus frequencyStimulus cycleSynaptic vesiclesStimulus contrastStrong stimulusSynaptic noiseDepolarizationNeuronsParadoxical findingsMembrane potentialSame cells
2003
Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities
Zaghloul KA, Boahen K, Demb JB. Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities. Journal Of Neuroscience 2003, 23: 2645-2654. PMID: 12684450, PMCID: PMC6742092, DOI: 10.1523/jneurosci.23-07-02645.2003.Peer-Reviewed Original ResearchConceptsOFF cellsGanglion cellsSynaptic inputsContrast sensitivityExcitatory conductanceOFF retinal ganglion cellsOFF ganglion cellsBasal glutamate releaseRetinal ganglion cellsBrisk-transient cellsGuinea pig retinaBipolar terminalsPresynaptic circuitsGlutamate releaseIntracellular recordingsON pathwayPig retinaSubthreshold membrane potentialsLight incrementsL-APMembrane potentialCellsMean luminancePathwayRetina