2024
Long‐Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER‐OLE Study
Masri A, Lester S, Stendahl J, Hegde S, Sehnert A, Balaratnam G, Shah A, Fox S, Wang A. Long‐Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER‐OLE Study. Journal Of The American Heart Association 2024, 13: e030607. PMID: 38591260, PMCID: PMC11262496, DOI: 10.1161/jaha.123.030607.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathyKansas City Cardiomyopathy Questionnaire–Overall Summary scoreSymptomatic obstructive hypertrophic cardiomyopathyOutflow tract gradientHypertrophic cardiomyopathyNew York Heart Association class improvementLeft ventricular outflow tract gradientTreatment-emergent adverse eventsSerum NT-proBNP levelsLeft ventricular ejection fractionEffect of mavacamtenIndividual dose titrationNT-proBNP levelsVentricular ejection fractionSerum NT-proBNPSummary scoreLong-term safetyLonger-term treatmentDose titrationEjection fractionNT-proBNPB-blockersReduced doseAdverse eventsInterim results
2023
Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry
Alaiwi S, Roston T, Marstrand P, Claggett B, Parikh V, Helms A, Ingles J, Lampert R, Lakdawala N, Michels M, Owens A, Rossano J, Saberi S, Abrams D, Ashley E, Semsarian C, Stendahl J, Ware J, Miller E, Ryan T, Russell M, Day S, Olivotto I, Vissing C, Ho C. Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry. Circulation 2023, 148: 394-404. PMID: 37226762, PMCID: PMC10373850, DOI: 10.1161/circulationaha.122.062517.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic dysfunctionHypertrophic cardiomyopathyMedian ageHCM diagnosisVentricular assist device implantationCox proportional hazards modelComposite of deathVentricular systolic dysfunctionAssist device implantationVentricular ejection fractionProportional hazards modelCardiac transplantationSystolic dysfunctionEjection fractionHCM cohortPediatric cohortDevice implantationPoor outcomeSubsequent prognosisEchocardiographic reportsHazards modelPatientsAdult cohortPrognosisCohort
2022
Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging. Journal Of Nuclear Medicine 2022, 63: 986-994. PMID: 35772956, PMCID: PMC9258561, DOI: 10.2967/jnumed.121.263507.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiovascular imagingDevice-related thrombusDetection of thrombusUnmet diagnostic needsFibroblast activation proteinCardiovascular fibrosisCardiovascular inflammationRisk stratificationDiagnostic needsCardiovascular calcificationMyocardial infarctionInflammatory responseUnmet ClinicalNew radiotracersCardiovascular medicinePersonalized therapyFibrosisActivation proteinSPECT imagingAmyloidosisCalcificationThrombosisInflammationRadiotracer developmentThrombusRadiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnmet diagnostic needsCardiovascular medicineNeuronal imagingImaging of inflammationHeart failureValvular diseaseTechnical considerationsDiagnostic needsCardiac amyloidosisUnmet ClinicalNew radiotracersCardiovascular imagingPersonalized therapyPerfusion tracerPET perfusion tracerThrombosisRadiotracer developmentRadiotracerPerfusionF-FlurpiridazImagingReviewMedicineKey technical considerationsMolecular characterization
2020
Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention
Stendahl JC, Liu Z, Boutagy NE, Nataneli E, Daghighian F, Sinusas AJ. Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention. Journal Of Nuclear Cardiology 2020, 29: 663-676. PMID: 32820423, PMCID: PMC7895860, DOI: 10.1007/s12350-020-02317-8.Peer-Reviewed Original Research11C-acetate PET: A powerful tool to analyze metabolic and functional changes in the heart related to alcohol consumption
Stendahl JC, Sinusas AJ. 11C-acetate PET: A powerful tool to analyze metabolic and functional changes in the heart related to alcohol consumption. Journal Of Nuclear Cardiology 2020, 29: 289-292. PMID: 32676907, PMCID: PMC7854759, DOI: 10.1007/s12350-020-02268-0.Commentaries, Editorials and LettersFeasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals
Wu J, Boutagy NE, Cai Z, Lin SF, Zheng MQ, Feher A, Stendahl JC, Kapinos M, Gallezot JD, Liu H, Mulnix T, Zhang W, Lindemann M, Teng JK, Miller EJ, Huang Y, Carson RE, Sinusas AJ, Liu C. Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals. Journal Of Nuclear Cardiology 2020, 29: 216-225. PMID: 32415628, PMCID: PMC7666654, DOI: 10.1007/s12350-020-02184-3.Peer-Reviewed Original Research
2017
Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT
Liu Q, Mohy-ud-Din H, Boutagy N, Jiang M, Ren S, Stendahl J, Sinusas A, Liu C. Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT. Physics In Medicine And Biology 2017, 62: 3944-3957. PMID: 28266929, PMCID: PMC5568763, DOI: 10.1088/1361-6560/aa6520.Peer-Reviewed Original ResearchConceptsMulti-atlas segmentation methodLabel fusion methodMulti-atlas segmentationSegmentation methodConventional label fusion methodsFusion methodManual segmentationMultiple organ segmentationLabel fusion algorithmImage qualityCardiac SPECT imagesDice similarity coefficientOrgan segmentationSegmentation accuracyAutomatic segmentationCTA segmentationFusion algorithmComputed tomography angiography dataSegmentationOne-out approachCT datasetsTomography angiography dataSimilarity coefficientAngiography dataConsistent image quality
2015
Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 2: Radiolabeled Probes
Stendahl JC, Sinusas AJ. Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 2: Radiolabeled Probes. Journal Of Nuclear Medicine 2015, 56: 1637-1641. PMID: 26294304, PMCID: PMC4934892, DOI: 10.2967/jnumed.115.164145.BooksConceptsSmall molecule agentsTherapeutic deliveryNanoparticlesMolecular imagingDistinct propertiesTherapeutic applicationsFurther technologic developmentsTheranosticsAddress safety concernsProbeFunctional versatilitySignificant potentialAgentsClinical translationVersatilityPropertiesApplicationsPreclinical cardiovascular researchCurrent examplesNanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features
Stendahl JC, Sinusas AJ. Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features. Journal Of Nuclear Medicine 2015, 56: 1469-1475. PMID: 26272808, PMCID: PMC4934895, DOI: 10.2967/jnumed.115.160994.BooksConceptsTherapeutic deliveryMultifunctional imaging agentsTargeted molecular imagingTunable propertiesSmall moleculesVersatile platformNanoparticlesUnique propertiesSmall molecule agentsImaging agentIntriguing attributesClinical translationMolecular imagingPharmacokinetic limitationsPropertiesElimination propertiesDiscusses challengesScope of applicationMoleculesHigh-resolution imaging modalityDeliveryMicroparticlesAgentsBiodistributionPlatform
2013
Massive Interventricular Septal Aneurysm and Stroke in a Healthy Young Patient: Guilt by Association?
Stendahl JC, Hasan AS, Simegn MA. Massive Interventricular Septal Aneurysm and Stroke in a Healthy Young Patient: Guilt by Association? Journal Of Stroke And Cerebrovascular Diseases 2013, 23: 590-591. PMID: 23747177, DOI: 10.1016/j.jstrokecerebrovasdis.2013.05.010.Peer-Reviewed Case Reports and Technical NotesConceptsMembranous interventricular septumInterventricular septumRight middle cerebral artery ischemic strokeMiddle cerebral artery ischemic strokeLeft-sided body weaknessAcute-onset confusionHealthy young patientsSystemic thrombolytic therapyUncommon cardiac defectMechanism of strokeInterventricular septal aneurysmMassive aneurysmEmbolic strokeBody weaknessIschemic strokeSeptal aneurysmYounger patientsExtensive workupSurgical morbidityThrombolytic therapyComplete resolutionCardiac defectsStrokeAneurysmsPatients
2009
Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation
Stendahl JC, Kaufman DB, Stupp SI. Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation. Cell Transplantation 2009, 18: 1-12. PMID: 19476204, PMCID: PMC2724969, DOI: 10.3727/096368909788237195.Books
2008
Growth Factor Delivery From Self-Assembling Nanofibers to Facilitate Islet Transplantation
Stendahl JC, Wang LJ, Chow LW, Kaufman DB, Stupp SI. Growth Factor Delivery From Self-Assembling Nanofibers to Facilitate Islet Transplantation. Transplantation 2008, 86: 478-481. PMID: 18698254, PMCID: PMC2585821, DOI: 10.1097/tp.0b013e3181806d9d.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalFibroblast Growth Factor 2HeparinHumansIslets of Langerhans TransplantationMaleMiceMice, TransgenicNanostructuresNeovascularization, PhysiologicOmentumPeptidesRecombinant ProteinsTime FactorsTissue ScaffoldsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2