Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family
Swerdlow R, Parks J, Davis J, Cassarino D, Trimmer P, Currie L, Dougherty J, Bridges W, Bennett J, Wooten G, Parker W. Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family. Annals Of Neurology 1998, 44: 873-881. PMID: 9851431, DOI: 10.1002/ana.410440605.Peer-Reviewed Original ResearchConceptsCybrid linesMaternal descendantsComplex I dysfunctionInherited mtDNA mutationsCybrid cell linesIncreased reactive oxygen species productionReactive oxygen species productionComplex I activityMitochondrial DNAMtDNA mutationsHuman neuroblastoma cellsFamily membersMitochondrial morphologyMtDNACytoplasmic hybridsPaternal descendantsOxygen species productionCybridsGenetic lesionsMatrilineal inheritanceMaternal lineMultiple membersI activityNeuroblastoma cellsEnzyme activity