2015
Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors
Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors. Journal Of Virology 2015, 89: 6711-6724. PMID: 25878115, PMCID: PMC4468483, DOI: 10.1128/jvi.00709-15.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusBrain tumorsVesicular stomatitis virusChimeric virusesBrain cancerLassa virusEbola virusMarburg virusRabies virusAdverse neurologic consequencesExquisite tumor specificityHigh-grade tumorsPromising oncolytic virusLassa virus glycoprotein precursorAdverse side effectsTumor-bearing miceMetastatic cancer modelsStomatitis virusNovel chimeric virusHigh-grade glioblastomaEbola virus glycoproteinMultiple cancer typesNoninjected tumorNeurologic consequencesOncolytic potential
2012
Highly Attenuated Recombinant Vesicular Stomatitis Virus VSV-12′GFP Displays Immunogenic and Oncolytic Activity
van den Pol A, Davis J. Highly Attenuated Recombinant Vesicular Stomatitis Virus VSV-12′GFP Displays Immunogenic and Oncolytic Activity. Journal Of Virology 2012, 87: 1019-1034. PMID: 23135719, PMCID: PMC3554062, DOI: 10.1128/jvi.01106-12.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression ProfilingGenes, ReporterGliomaGreen Fluorescent ProteinsHumansMiceMice, SCIDMolecular Sequence DataOncolytic VirusesRNA, ViralSequence Analysis, DNASurvival AnalysisTreatment OutcomeVaccines, AttenuatedVaccines, SyntheticVesiculovirusViral Plaque AssayViral VaccinesConceptsVesicular stomatitis virusGreen fluorescent proteinReporter geneOne-step growth curveVesicular stomatitis virus genomeAttenuated vesicular stomatitis virusCancer cellsHigh-titer antibody responsesInjection of tumorHuman cancer cellsSuppressed tumor growthRNA transcriptsOncolytic virusesIntratumoral injectionSCID micePostnatal daySafety profileFluorescent proteinTumor growthVSV-G/GFPGenesRecombinant virusesStomatitis virusImmune responseAntibody response