Evidence That Two Reports of mtDNA Cytochrome c Oxidase “Mutations” in Alzheimer's Disease Are Based on nDNA Pseudogenes of Recent Evolutionary Origin
Davis J, Parker W. Evidence That Two Reports of mtDNA Cytochrome c Oxidase “Mutations” in Alzheimer's Disease Are Based on nDNA Pseudogenes of Recent Evolutionary Origin. Biochemical And Biophysical Research Communications 1998, 244: 877-883. PMID: 9535760, DOI: 10.1006/bbrc.1998.8353.Peer-Reviewed Original ResearchConceptsEvolutionary originAmplification of nuclear DNACytochrome c oxidase subunitEtiology of Alzheimer's diseaseHeteroplasmic mitochondrial DNAAlzheimer's diseaseMtDNA pseudogenesMitochondrial DNAPCR artifactsNuclear DNASequence variabilityMtDNAPseudogenesNT2 cellsHigher abundanceMutationsAlzheimer's disease subjectsDNAAlzheimerNDNAGenesSubunitSequencePCRAbundance