2020
Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors
Zhang X, Zhang T, Davis JN, Marzi A, Marchese AM, Robek MD, van den Pol AN. Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors. Journal Of Virology 2020, 94: 10.1128/jvi.01967-19. PMID: 32051271, PMCID: PMC7108827, DOI: 10.1128/jvi.01967-19.Peer-Reviewed Original ResearchConceptsChimeric vesicular stomatitis virusVSV-EBOVNormal brain cellsBrain tumorsVesicular stomatitis virusEBOV glycoproteinEbola virus glycoproteinEbola virusBrain cellsNormal immunocompetent miceBrain tumor-bearing miceImmunodeficient SCID miceTumor-bearing miceHuman brain tumorsSCID mouse brainStomatitis virusTranscription-quantitative PCRMost tumor cellsVirus glycoproteinOncolytic actionImmune system evasionImmunocompetent miceWild-type vesicular stomatitis virusSCID miceVirus infection
2017
Chikungunya, Influenza, Nipah, and Semliki Forest Chimeric Viruses with Vesicular Stomatitis Virus: Actions in the Brain
van den Pol AN, Mao G, Chattopadhyay A, Rose JK, Davis JN. Chikungunya, Influenza, Nipah, and Semliki Forest Chimeric Viruses with Vesicular Stomatitis Virus: Actions in the Brain. Journal Of Virology 2017, 91: 10.1128/jvi.02154-16. PMID: 28077641, PMCID: PMC5331823, DOI: 10.1128/jvi.02154-16.Peer-Reviewed Original ResearchConceptsAdult mouse brainVesicular stomatitis virusVSV glycoprotein (G) geneAdult brainChimeric virusesOncolytic virusesVirus-like vesiclesChimeric vesicular stomatitis virusMouse brainSemliki Forest virusStomatitis virusPostnatal day 14 miceHealthy adult mouse brainRecombinant vesicular stomatitis virusKey immune mechanismsType I interferon responseG glycoproteinI interferon responseInterferon-stimulated genesDay 14 miceInfluenza H5N1 virusGlycoprotein geneNeurotropic natureIntranasal inoculationWild-type vesicular stomatitis virus