2014
T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans
McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E. T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2637-2643. PMID: 25341798, PMCID: PMC4445971, DOI: 10.1161/atvbaha.114.304636.Peer-Reviewed Original ResearchConceptsCD8 T cellsSubcutaneous adipose tissueT cell profileInsulin resistanceT cellsAdipose tissueSystemic inflammationPeripheral bloodPlasma high-sensitivity C-reactive protein concentrationsHigh-sensitivity C-reactive protein concentrationsAnti-inflammatory T cellsAnti-inflammatory interleukin-10C-reactive protein concentrationsDiet-induced obese miceObesity-associated metabolic diseasesInsulin-mediated glucose disposalProinflammatory T helperPlasma interleukin-6T cell subsetsInsulin suppression testT-cell phenotypeSystemic insulin resistanceAdipose tissue biopsiesObese human subjectsReal-time polymerase chain reaction
2009
Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women
Liu A, McLaughlin T, Liu T, Sherman A, Yee G, Abbasi F, Lamendola C, Morton J, Cushman SW, Reaven GM, Tsao PS. Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women. Obesity Surgery 2009, 19: 1564. PMID: 19711137, PMCID: PMC3181138, DOI: 10.1007/s11695-009-9949-9.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueSubcutaneous adipose tissueBody mass indexInflammatory activityAdipose tissueIR individualsAbdominal subcutaneous adipose tissueOmental visceral adipose tissueInsulin-resistant womenInsulin suppression testDegree of adiposityInsulin-sensitive individualsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionAdipocyte differentiation genesRegional fat storageIR womenBeckman Coulter MultisizerSmall adipose cellsBariatric surgeryObese womenObese/Mass indexLarge cellsAdipocyte hypertrophyPlasma Glucose and Insulin Regulation Is Abnormal Following Gastric Bypass Surgery with or Without Neuroglycopenia
Kim SH, Liu TC, Abbasi F, Lamendola C, Morton JM, Reaven GM, McLaughlin TL. Plasma Glucose and Insulin Regulation Is Abnormal Following Gastric Bypass Surgery with or Without Neuroglycopenia. Obesity Surgery 2009, 19: 1550. PMID: 19557485, DOI: 10.1007/s11695-009-9893-8.Peer-Reviewed Original ResearchConceptsGastric bypass surgeryInsulin sensitivityOral glucoseInsulin concentrationsPost-RYGBBypass surgeryPlasma glucoseInsulin responseControl groupOverweight/obese controlsInsulin suppression testOral glucose challengePeak insulin concentrationsNon-surgical controlsNadir glucose concentrationsAsymptomatic patientsSymptomatic hypoglycemiaObese controlsRYGB groupGlucose challengeSuppression testPeak glucosePatientsRYGBGlucose concentration