Surgical Stress-Induced Immune Cell Redistribution Profiles Predict Short-Term and Long-Term Postsurgical Recovery
Rosenberger PH, Ickovics JR, Epel E, Nadler E, Jokl P, Fulkerson JP, Tillie JM, Dhabhar FS. Surgical Stress-Induced Immune Cell Redistribution Profiles Predict Short-Term and Long-Term Postsurgical Recovery. Journal Of Bone And Joint Surgery 2009, 91: 2783-2794. PMID: 19952239, PMCID: PMC2780920, DOI: 10.2106/jbjs.h.00989.Peer-Reviewed Original ResearchConceptsImmune cell redistributionCell redistributionPostoperative recoveryImmune responseLong-term postoperative recoveryMixed-model repeated-measures analysisProtective immune responseSite of surgeryProspective longitudinal studyOptimum immune responseRepeated-measures analysisLysholm scaleSurgical stressKnee functionPostsurgical recoveryPostoperative healingLeukocyte redistributionSurgeryEnhanced recoveryExtent of recoveryRate of recoveryPatientsPotential mediatorsPhysiological stress responsePoor recovery