2015
Multimodality Imaging of Diseases of the Thoracic Aorta in Adults: From the American Society of Echocardiography and the European Association of Cardiovascular Imaging Endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance
Goldstein SA, Evangelista A, Abbara S, Arai A, Asch FM, Badano LP, Bolen MA, Connolly HM, Cuéllar-Calàbria H, Czerny M, Devereux RB, Erbel RA, Fattori R, Isselbacher EM, Lindsay JM, McCulloch M, Michelena HI, Nienaber CA, Oh JK, Pepi M, Taylor AJ, Weinsaft JW, Zamorano JL, Editors C, Dietz H, Eagle K, Elefteriades J, Jondeau G, Rousseau H, Schepens M. Multimodality Imaging of Diseases of the Thoracic Aorta in Adults: From the American Society of Echocardiography and the European Association of Cardiovascular Imaging Endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance. Journal Of The American Society Of Echocardiography 2015, 28: 119-182. PMID: 25623219, DOI: 10.1016/j.echo.2014.11.015.Peer-Reviewed Original Research
2013
Preoperative angiotensin-converting enzyme inhibitors and angiotensin receptor blocker use and acute kidney injury in patients undergoing cardiac surgery
Coca SG, Garg AX, Swaminathan M, Garwood S, Hong K, Thiessen-Philbrook H, Passik C, Koyner JL, Parikh CR, Consortium O, Jai R, Jeevanandam V, Akhter S, Devarajan P, Bennett M, Edelsteinm C, Patel U, Chu M, Goldbach M, Guo L, McKenzie N, Myers M, Novick R, Quantz M, Zappitelli M, Dewar M, Darr U, Hashim S, Elefteriades J, Geirsson A. Preoperative angiotensin-converting enzyme inhibitors and angiotensin receptor blocker use and acute kidney injury in patients undergoing cardiac surgery. Nephrology Dialysis Transplantation 2013, 28: 2787-2799. PMID: 24081864, PMCID: PMC3811062, DOI: 10.1093/ndt/gft405.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsBiomarkersCardiac Surgical ProceduresCoronary Artery DiseaseFemaleHumansIncidenceKidney Function TestsMaleMiddle AgedPreoperative CarePrognosisProspective StudiesReceptors, AngiotensinUnited StatesConceptsStructural acute kidney injuryAcute kidney injuryAngiotensin-converting enzyme inhibitorAngiotensin receptor blockersACEI/angiotensin receptor blockerACEI/ARB exposureKidney injurySerum creatinineARB exposureCardiac surgeryUrinary biomarkersEnzyme inhibitorsPreoperative angiotensin-converting enzyme inhibitorACEI/ARB usageAngiotensin receptor blocker useFunctional acute kidney injuryPostoperative acute kidney injuryACEI/ARB useAKI stage 1New urinary biomarkersMorning of surgeryReceptor blocker useCo-primary outcomesProspective cohort studyARB usage
2009
Deep Hypothermic Circulatory Arrest in Patients With High Cognitive Needs: Full Preservation of Cognitive Abilities
Percy A, Widman S, Rizzo JA, Tranquilli M, Elefteriades JA. Deep Hypothermic Circulatory Arrest in Patients With High Cognitive Needs: Full Preservation of Cognitive Abilities. The Annals Of Thoracic Surgery 2009, 87: 117-123. PMID: 19101283, DOI: 10.1016/j.athoracsur.2008.10.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationCase-Control StudiesCirculatory Arrest, Deep Hypothermia InducedCognitionCognition DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient SatisfactionPostoperative CarePreoperative CareProbabilityPsychometricsRadiographyReference ValuesRetrospective StudiesRisk AssessmentSurveys and QuestionnairesTreatment OutcomeVascular Surgical ProceduresConceptsDeep hypothermic circulatory arrestHypothermic circulatory arrestAortic surgeryCirculatory arrestStudy groupStraight deep hypothermic circulatory arrestYale-New Haven HospitalOpen distal anastomosisThoracic aortic surgeryTotal arch replacementArch replacementCerebral protectionPreoperative statusDistal anastomosisSuch patientsFunctional outcomeControl subjectsPatientsSurgeryControl groupAdverse effectsSignificant differencesCognitive changesDaily activitiesOverall score
2008
Unilateral diaphragm paralysis: etiology, impact, and natural history.
Elefteriades J, Singh M, Tang P, Siegel MD, Kenney B, Pandey A, Kopf GS. Unilateral diaphragm paralysis: etiology, impact, and natural history. The Journal Of Cardiovascular Surgery 2008, 49: 289-95. PMID: 18431352.Peer-Reviewed Original ResearchConceptsUnilateral diaphragm paralysisDiaphragm paralysisChronic obstructive pulmonary diseaseNatural historyBilateral diaphragm paralysisIntact phrenic nerveObstructive pulmonary diseaseSpirometric improvementClinical improvementExpiratory volumePulmonary infectionDiaphragm resectionLeft diaphragmOccasional patientPhrenic nervePulmonary diseaseSurgical explorationDiaphragm functionLower lobeVital capacityClinical recordsClinical spectrumMean durationNeurogenic atrophyBest therapy
2007
What Is the Optimal Management of Late-Presenting Survivors of Acute Type A Aortic Dissection?
Davies RR, Coe MP, Mandapati D, Gallo A, Botta DM, Elefteriades JA, Coady MA. What Is the Optimal Management of Late-Presenting Survivors of Acute Type A Aortic Dissection? The Annals Of Thoracic Surgery 2007, 83: 1593-1602. PMID: 17462364, DOI: 10.1016/j.athoracsur.2006.12.018.Peer-Reviewed Original ResearchConceptsLong-term survivalOperative repairAortic dissectionGroup AAcute Type A Aortic DissectionType A Aortic DissectionImproved long-term survivalOptimal managementExcellent long-term resultsA Aortic DissectionInitial medical managementCongestive heart failureCoronary artery diseaseOnset of symptomsLong-term resultsImmediate operative repairAcute typeSurgical emergencySymptom onsetArtery diseaseHeart failurePulmonary diseaseMedical managementSingle institutionGroup B
2006
Familial Thoracic Aortic Aneurysms and Dissections—Incidence, Modes of Inheritance, and Phenotypic Patterns
Albornoz G, Coady MA, Roberts M, Davies RR, Tranquilli M, Rizzo JA, Elefteriades JA. Familial Thoracic Aortic Aneurysms and Dissections—Incidence, Modes of Inheritance, and Phenotypic Patterns. The Annals Of Thoracic Surgery 2006, 82: 1400-1405. PMID: 16996941, DOI: 10.1016/j.athoracsur.2006.04.098.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAbdominal aortic aneurysmFamilial thoracic aortic aneurysmsAortic aneurysmMarfan syndromeAortic growth rateNon-Marfan patientsIncidence of hypertensionAggressive clinical entityPredominant inheritance patternSporadic groupMarfan groupStudy patientsCerebral circulationClinical entityThoracic aortaAbdominal aortaInheritance patternMFS groupMFS patientsTAA groupLarge cohortAneurysm sitePatientsAneurysms
2005
Late-onset dysphagia lusoria assessed by 3-dimensional computed tomography of an aortic arch abnormality
Koullias G, Korkolis D, Iams W, Elefteriades J. Late-onset dysphagia lusoria assessed by 3-dimensional computed tomography of an aortic arch abnormality. Diseases Of The Esophagus 2005, 18: 60-63. PMID: 15773845, DOI: 10.1111/j.1442-2050.2005.00449.x.Peer-Reviewed Original ResearchConceptsAberrant left subclavian arteryLeft-sided ligamentum arteriosumRight-sided aortic archLate-onset dysphagiaSymptomatic vascular ringsLeft subclavian arteryAortic arch abnormalitiesHelical CT scansArch aortogramDysphagia lusoriaSubclavian arteryIntraoperative findingsPatient's symptomsLigamentum arteriosumAnatomic abnormalitiesAortic archArch abnormalitiesVascular ringComplete decompressionCT scanComputed tomographyThree-dimensional reconstruction softwareDysphagiaSymptomsAbnormalities
1999
DEVELOPING SURGICAL INTERVENTION CRITERIA FOR THORACIC AORTIC ANEURYSMS
Coady M, Rizzo J, Elefteriades J. DEVELOPING SURGICAL INTERVENTION CRITERIA FOR THORACIC AORTIC ANEURYSMS. Cardiology Clinics 1999, 17: 827-839. PMID: 10589349, DOI: 10.1016/s0733-8651(05)70118-1.Peer-Reviewed Original ResearchConceptsSurgical interventionAcute ascending aortic dissectionAscending aortic dissectionConcomitant aortic insufficiencyIntervention criteriaLarger patient numbersAppropriate clinical careThoracic aortic aneurysmSize criteriaSurgical intervention criteriaOverall physical conditionAortic insufficiencyAdverse eventsAortic dissectionPatient ageAortic sizeOrgan compressionPatient enrollmentPatient numbersAortic aneurysmThoracic aortaSymptomatic stateClinical careClinical experienceLife expectancyFailure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome
Samady H, Elefteriades J, Abbott B, Mattera J, McPherson C, Wackers F. Failure to Improve Left Ventricular Function After Coronary Revascularization for Ischemic Cardiomyopathy Is Not Associated With Worse Outcome. Circulation 1999, 100: 1298-1304. PMID: 10491374, DOI: 10.1161/01.cir.100.12.1298.Peer-Reviewed Original ResearchConceptsVentricular functionIschemic cardiomyopathyGroup AHeart failure scoreLeft ventricular functionIschemic LV dysfunctionPoor patient outcomesB. Group ALack of improvementBaseline LVEFEffective revascularizationImproved LVEFCoronary revascularizationLV dysfunctionConsecutive patientsIntraoperative variablesPostoperative improvementCardiac deathLV functionPoor outcomeViable myocardiumLVEF assessmentIschemic myocardiumPatient outcomesWorse outcomesSurgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications
Coady M, Rizzo J, Hammond G, Kopf G, Elefteriades J. Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications. The Annals Of Thoracic Surgery 1999, 67: 1922-1926. PMID: 10391339, DOI: 10.1016/s0003-4975(99)00431-2.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmDevastating complicationAortic growth rateComplications of ruptureIncidence of dissectionTime of complicationsRisk of dissectionMultivariable regression analysisMedian sizeSurgical intervention criteriaTime of dissectionAcute dissectionElective resectionPerioperative complicationsInitial presentationSurgical interventionRisk factorsThoracic aortaAneurysm sizeComplicationsTime of ruptureYale University SchoolLower mortalityAneurysmsFamilial Patterns of Thoracic Aortic Aneurysms
Coady M, Davies R, Roberts M, Goldstein L, Rogalski M, Rizzo J, Hammond G, Kopf G, Elefteriades J. Familial Patterns of Thoracic Aortic Aneurysms. JAMA Surgery 1999, 134: 361-367. PMID: 10199307, DOI: 10.1001/archsurg.134.4.361.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmSporadic thoracic aortic aneurysmConcomitant aortic dissectionAortic dissectionAortic aneurysmMarfan syndromeAortic diseaseAutosomal recessive modeFamilial patternMean ageFamily historyRecessive modeCollagen vascular disordersTime of diagnosisThoracic aortic diseaseGenetic factorsNew risk factorsFamily pedigreeConcomitant diseasesRetrospective reviewAortic sizeUniversity HospitalRisk factorsVascular disordersAutosomal dominant mode
1998
Funnel graft to innominate vein to control epicardial bleeding
Mehta I, Elefteriades J. Funnel graft to innominate vein to control epicardial bleeding. The Annals Of Thoracic Surgery 1998, 66: 1413-1414. PMID: 9800848, DOI: 10.1016/s0003-4975(98)00786-3.Peer-Reviewed Original Research
1997
Results of Coronary Artery Bypass Grafting by a Single Surgeon Patients With Left Ventricular Ejection Fractions ≤30%
Elefteriades J, Morales D, Gradel C, Tollis G, Levi E, Zaret B. Results of Coronary Artery Bypass Grafting by a Single Surgeon Patients With Left Ventricular Ejection Fractions ≤30%. The American Journal Of Cardiology 1997, 79: 1573-1578. PMID: 9202343, DOI: 10.1016/s0002-9149(97)00201-4.Peer-Reviewed Original ResearchConceptsAdvanced LV dysfunctionInternal mammary arteryCoronary artery diseaseEjection fractionLV dysfunctionMammary arteryArtery diseaseCongestive heart failure classSevere left ventricular dysfunctionCoronary Artery Bypass GraftingBetter long-term survivalHeart failure classSingle surgeon's patientsArtery Bypass GraftingCoronary artery bypassHigh operative riskLeft ventricular dysfunctionSevere ventricular arrhythmiasLV ejection fractionVentricular ejection fractionUse of CABGLong-term survivalQuality of lifeAngina classArtery bypassWhat is the appropriate size criterion for resection of thoracic aortic aneurysms?
Coady M, Rizzo J, Hammond G, Mandapati D, Darr U, Kopf G, Elefteriades J. What is the appropriate size criterion for resection of thoracic aortic aneurysms? Journal Of Thoracic And Cardiovascular Surgery 1997, 113: 476-491. PMID: 9081092, DOI: 10.1016/s0022-5223(97)70360-x.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmIncidence of dissectionTime of complicationsMultivariable regression analysisMedian sizeAppropriate size criterionTime of dissectionAcute dissectionElective resectionPerioperative complicationsDevastating complicationOverall survivalAortic dissectionInitial presentationElective operationsSurgical interventionRisk factorsThoracic aortaAneurysm sizeTime of rupturePatientsYale University SchoolAneurysmsLower mortality
1996
Diaphragm Pacing with a Quadripolar Phrenic Nerve Electrode: An International Study
WEESE‐MAYER D, SILVESTRI J, KENNY A, ILBAWI M, HAUPTMAN S, LIPTON J, TALONEN P, GARCIA H, WATT J, EXNER G, BAER G, ELEFTERIADES J, PERUZZI W, ALEX C, HARLID R, VINCKEN W, DAVIS G, DECRAMER M, KUENZLE C, SÆTERHAUG A, SCHÖBER J. Diaphragm Pacing with a Quadripolar Phrenic Nerve Electrode: An International Study. Pacing And Clinical Electrophysiology 1996, 19: 1311-1319. PMID: 8880794, DOI: 10.1111/j.1540-8159.1996.tb04209.x.Peer-Reviewed Original ResearchConceptsCongenital central hypoventilation syndromeActive pediatric patientsAdult patientsTetraplegic patientsPediatric patientsIdiopathic congenital central hypoventilation syndromePhrenic nerve electrodesIncidence of complicationsCentral hypoventilation syndromeHours/dayHypoventilation syndromePatient groupCCHS patientsRegistry dataSurgical proceduresMechanical traumaPatientsAbsent functionSuccessful pacingComplicationsIncidenceNerve electrodesLongitudinal studySignificant differencesNecessary interventions
1995
Dynamic Cardiomyoplasty
Letsou G, Austin L, Grandjean P, Braxton J, Elefteriades J. Dynamic Cardiomyoplasty. Cardiology Clinics 1995, 13: 121-124. PMID: 7796426, DOI: 10.1016/s0733-8651(18)30068-7.Peer-Reviewed Original ResearchConceptsSystolic performanceNYHA class III heart failureClass III heart failureProgressive left ventricular dilatationLeft ventricular dilatationRandomized clinical trialsMechanism of actionOperative riskSymptomatic improvementHeart failureVentricular dilatationDynamic cardiomyoplastyClinical trialsObjective improvementSurvival advantageLeft ventriclePromising new techniqueDefinitive answerPatientsCardiomyoplastyDilatationVentricleTrials
1993
Coronary artery bypass grafting in severe left ventricular dysfunction: Excellent survival with improved ejection fraction and functional state
Elefteriades J, Tolis G, Levi E, Mills L, Zaret B. Coronary artery bypass grafting in severe left ventricular dysfunction: Excellent survival with improved ejection fraction and functional state. Journal Of The American College Of Cardiology 1993, 22: 1411-1417. PMID: 8227799, DOI: 10.1016/0735-1097(93)90551-b.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdultAgedAged, 80 and overCause of DeathCoronary Artery BypassDefibrillators, ImplantableFemaleFollow-Up StudiesHeart DiseasesHospital MortalityHumansIntra-Aortic Balloon PumpingMaleMammary ArteriesMiddle AgedPrognosisQuality of LifeSeverity of Illness IndexStroke VolumeSurvival RateVentricular Function, LeftConceptsCoronary Artery Bypass GraftingArtery Bypass GraftingCoronary artery bypassSevere left ventricular dysfunctionLeft ventricular ejection fractionInternal mammary arteryLeft ventricular dysfunctionVentricular ejection fractionEjection fractionArtery bypassVentricular dysfunctionBypass GraftingMammary arteryMortality rateCanadian Cardiovascular Society angina classCongestive heart failure classGood medium-term survivalAdvanced ischemic cardiomyopathyAdvanced ventricular dysfunctionHeart failure classImproved ejection fractionHospital mortality rateCongestive heart failureIntraaortic balloon pumpSignificant ventricular arrhythmiasLinear left ventricular aneurysmectomy: Modern imaging studies reveal improved morphology and function
Elefteriades J, Solomon L, Salazar A, Batsford W, Baldwin J, Kopf G. Linear left ventricular aneurysmectomy: Modern imaging studies reveal improved morphology and function. The Annals Of Thoracic Surgery 1993, 56: 242-252. PMID: 8347005, DOI: 10.1016/0003-4975(93)91154-f.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIntraoperative transesophageal echocardiographyArtery bypassVentricular aneurysmectomyTransesophageal echocardiographyConcomitant coronary artery bypassCongestive heart failure classFrank congestive heart failureHeart failure classActuarial survival rateHospital mortality rateCongestive heart failureWall motion scoreMean wall motion scoreModern imaging studiesMagnetic resonance imagingAcquisition scanningAnginal classValve replacementConsecutive patientsEjection fractionHeart failureVentricular functionEndocardial resectionVentricular morphology
1992
Thermodilution right ventricular ejection fraction measurement reproducibility—A study in patients undergoing coronary artery bypass graft surgery
RAFFERTY T, DURKIN M, HINES R, ELEFTERIADES J, HARRIS S, O'CONNOR T. Thermodilution right ventricular ejection fraction measurement reproducibility—A study in patients undergoing coronary artery bypass graft surgery. Critical Care Medicine 1992, 20: 1524-1528. PMID: 1424694, DOI: 10.1097/00003246-199211000-00008.Peer-Reviewed Original ResearchConceptsRight ventricular systolic performanceVentricular systolic performanceHeart rateCardiac indexSystolic performanceRight ventricular end-diastolic volume indexRight ventricular ejection fraction measurementsCoronary artery bypass graft surgeryVentricular end-diastolic volume indexCoronary artery bypass graft patientsArtery bypass graft surgeryEnd-diastolic volume indexRight ventricular ejection fractionVentricular ejection fraction measurementsBypass graft surgeryBypass graft patientsVentricular ejection fractionRight atrial areaEjection fraction measurementsGraft patientsGraft surgeryDiastolic diameterEjection fractionAtrial areaProspective studyTransesophageal echocardiographic evaluation of aortic valve integrity with antegrade crystalloid cardioplegic solution used as an imaging agent
Rafferty T, Durkin M, Elefteriades J, O’Connor T. Transesophageal echocardiographic evaluation of aortic valve integrity with antegrade crystalloid cardioplegic solution used as an imaging agent. Journal Of Thoracic And Cardiovascular Surgery 1992, 104: 637-641. PMID: 1513154, DOI: 10.1016/s0022-5223(19)34729-4.Peer-Reviewed Original ResearchConceptsCrystalloid cardioplegic solutionCardioplegic solutionValve dysfunctionValve integrityEchocardiographic contrast agentsImaging agentVentricular dimensional changesAortic regurgitationEchocardiographic evaluationLeft atriumCardiac dimensionsIntravascular injectionSolution administrationPatientsDysfunctionContrast agentsAgentsEchocardiographyRegurgitationAtriumAdministration