2011
Genetic associations with performance on a behavioral measure of distress intolerance
Amstadter AB, Daughters SB, MacPherson L, Reynolds EK, Danielson CK, Wang F, Potenza MN, Gelernter J, Lejuez CW. Genetic associations with performance on a behavioral measure of distress intolerance. Journal Of Psychiatric Research 2011, 46: 87-94. PMID: 22024485, PMCID: PMC3687355, DOI: 10.1016/j.jpsychires.2011.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCatechol O-MethyltransferaseChildChi-Square DistributionDistrict of ColumbiaFemaleGene FrequencyGenetic Association StudiesGenotypeHumansLongitudinal StudiesMaleMood DisordersPolymorphism, Single NucleotidePsychiatric Status Rating ScalesRegression AnalysisRisk-TakingSerotonin Plasma Membrane Transport ProteinsConceptsEmotion regulation difficultiesDistress intoleranceBehavioral measuresPoor psychological functioningAdolescent risk behaviorsDistress tolerancePsychological functioningLarger longitudinal studyVal allele carriersYear old youthMet homozygotesEmotional abuseBehavioral indicatorsBehavioral assessmentLongitudinal studyGenetic influencesCandidate genetic polymorphismsTaskYouthDistressExploratory analysisRisk behaviorsEmpirical evidencePrior studiesDifficulties
2006
C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency
Jacobsen LK, Pugh KR, Mencl WE, Gelernter J. C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency. Psychopharmacology 2006, 188: 530-540. PMID: 16896957, DOI: 10.1007/s00213-006-0469-1.Peer-Reviewed Original ResearchConceptsMemory performanceEffects of nicotineBrain regionsBrain functionFunctional magnetic resonanceCortical processing efficiencyRange of behavioralC957T polymorphismProcessing efficiencyPhonological rehearsalMemory taskMemory loadBrain responsesPerformance accuracyC957TMemoryBehavioral effectsNicotine administrationDopamine D2 receptor geneConclusionsThese findingsTobacco dependenceIndividual variationIndividual responsesTaskPlacebo patch