2022
Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample
Kember RL, Hartwell EE, Xu H, Rotenberg J, Almasy L, Zhou H, Gelernter J, Kranzler HR. Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample. Biological Psychiatry 2022, 93: 536-545. PMID: 36273948, PMCID: PMC9931661, DOI: 10.1016/j.biopsych.2022.08.010.Peer-Reviewed Original ResearchConceptsSubstance use disordersAlcohol use disorderOpioid use disorderPolygenic risk scoresUse disordersCo-occurring psychiatric disordersComprehensive psychiatric interviewSemi-Structured AssessmentElectronic health recordsControl subjectsLow prevalencePsychiatric interviewRisk scorePsychiatric disordersPhenome-wide association analysisDrug dependenceEuropean individualsHealth recordsLifetime cannabisPhenome-wide association studyDisordersAfrican ancestry individualsDSM diagnosesPopulation sampleGenetic liabilityClinical and behavioral correlates in adult methamphetamine users with childhood exposure to household drug and alcohol use
Rattanasumawong W, Malison R, Gelernter J, Nunez Y, Kalayasiri R. Clinical and behavioral correlates in adult methamphetamine users with childhood exposure to household drug and alcohol use. The International Journal Of Alcohol And Drug Research 2022, 9: 77-84. DOI: 10.7895/ijadr.345.Peer-Reviewed Original ResearchAntisocial personality disorderBaseline socio-demographic informationMA useCross-sectional baseline dataPersonality disorderSevere clinical presentationMethamphetamine usersSocio-demographic informationGreater subsequent useSemi-Structured AssessmentCohort studyClinical presentationAdult methamphetamine usersFamily historyChildhood exposureDrug useRespective drugsAlcohol dependenceDrug dependenceDrug typeAlcohol useFamily exposureMA usersBaseline dataSelf-harm experience
2020
Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version
Yang BZ, Wang LJ, Huang MC, Wang SC, Tsai MC, Huang YC, Nuñez YZ, Ng MH, Kranzler HR, Gelernter J, Chen CK. Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version. Complex Psychiatry 2020, 6: 62-67. PMID: 34882761, PMCID: PMC7923924, DOI: 10.1159/000511606.Peer-Reviewed Original ResearchSD diagnosisSemi-Structured AssessmentTest-retest reliabilityDependence diagnosisDrug dependenceΚ statisticDiagnostic reliabilityStructured Clinical InterviewCohen κ statisticChance-corrected agreementClinician versionSubstance dependence diagnosesNicotine dependencePsychiatric disordersClinical InterviewAlcohol dependenceDSM-IVDiagnosisSubstance useChinese versionOpioidsValid instrumentConcurrent validityKetamineMethamphetamineIdentifying factors associated with opioid cessation in a biracial sample using machine learning
Cox JW, Sherva RM, Lunetta KL, Saitz R, Kon M, Kranzler HR, Gelernter J, Farrer LA. Identifying factors associated with opioid cessation in a biracial sample using machine learning. Exploration Of Medicine 2020, 1: 27-41. PMID: 33554217, PMCID: PMC7861053, DOI: 10.37349/emed.2020.00003.Peer-Reviewed Original ResearchOpioid cessationIndependent predictorsOpioid usePsychiatric disordersDrug useAfrican AmericansEuropean ancestryStrong independent predictorSignificant independent predictorsPopulation groupsRecent cocaine useSemi-Structured AssessmentGeneral healthEdition criteriaBiracial sampleOUD managementDifferent population groupsOverall healthCocaine useDrug dependenceMental disordersOlder ageSubsequent stepwise regressionUse behaviorsStatistical Manual
2017
Ancestry‐specific and sex‐specific risk alleles identified in a genome‐wide gene‐by‐alcohol dependence interaction study of risky sexual behaviors
Polimanti R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Ancestry‐specific and sex‐specific risk alleles identified in a genome‐wide gene‐by‐alcohol dependence interaction study of risky sexual behaviors. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 846-853. PMID: 28990359, PMCID: PMC5861711, DOI: 10.1002/ajmg.b.32604.Peer-Reviewed Original ResearchConceptsRisky sexual behaviorDSM-IV diagnosisSexual behaviorGenome-wide association studiesSex-specific analysesConcordance of findingsSemi-Structured AssessmentS100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours
Polimanti R, Meda SA, Pearlson GD, Zhao H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours. Journal Of Psychiatry And Neuroscience 2017, 42: 252-261. PMID: 28418321, PMCID: PMC5487272, DOI: 10.1503/jpn.160189.Peer-Reviewed Original ResearchConceptsRisky sexual behaviorCAD diagnosisLow-frequency fluctuation (ALFF) analysisMultiple sexual partnersLeft paracentral lobuleSexual behaviorAfrican American cohortSemi-Structured AssessmentALFF analysisSexual functionAfrican American participantsCalcium-binding proteinsParacentral lobuleIndependent cohortRight pallidumCalcium homeostasisUnprotected sexCannabis dependenceDrug dependenceSignificant associationBrain regionsSexual partnersFrequency fluctuation analysisPrevious genome-wide association studyCohortSex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center
Rungnirundorn T, Verachai V, Gelernter J, Malison RT, Kalayasiri R. Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center. Journal Of Addiction Medicine 2017, 11: 19. PMID: 27649265, PMCID: PMC5291761, DOI: 10.1097/adm.0000000000000262.Peer-Reviewed Original ResearchConceptsMA dependenceMA useLifetime episodesTreatment centersLogistic regression analysisResidential drug treatmentChi-square testSex differencesSemi-Structured AssessmentAntisocial personality disorderMA diagnosisMA withdrawalTreatment cohortsComorbid antisocial personality disorderAssociated FactorsDrug treatmentSex-specific differencesNicotine dependencePsychomotor retardationDrug dependenceLogistic regressionMethamphetamine useMA usersPersonality disorderMethamphetamine
2015
Genome‐wide association study of body mass index in subjects with alcohol dependence
Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genome‐wide association study of body mass index in subjects with alcohol dependence. Addiction Biology 2015, 22: 535-549. PMID: 26458734, PMCID: PMC5102811, DOI: 10.1111/adb.12317.Peer-Reviewed Original ResearchMeSH KeywordsAcid Anhydride HydrolasesAdenylyl CyclasesAdultAlcoholismAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAlpha-Ketoglutarate-Dependent Dioxygenase FTOBlack or African AmericanBody Mass IndexCell Adhesion MoleculesDNA-Binding ProteinsFemaleGenome-Wide Association StudyHSP40 Heat-Shock ProteinsHumansMaleMembrane ProteinsMiddle AgedNerve Tissue ProteinsObesityPolymorphism, Single NucleotideRab GTP-Binding ProteinsRetinal DehydrogenaseRNA, Long NoncodingTranscription FactorsWhite PeopleConceptsBody mass indexAlcohol dependenceMass indexBirth sizeAfrican AmericansDrug dependenceSemi-Structured AssessmentBody massInter-observer reliability of DSM-5 substance use disorders
Denis CM, Gelernter J, Hart AB, Kranzler HR. Inter-observer reliability of DSM-5 substance use disorders. Drug And Alcohol Dependence 2015, 153: 229-235. PMID: 26048641, PMCID: PMC4509850, DOI: 10.1016/j.drugalcdep.2015.05.019.Peer-Reviewed Original ResearchConceptsDSM-5 SUD diagnosesSUD diagnosisDSM-IV diagnosisLifetime moodInter-observer reliabilityDSM-5 substance use disordersDisorder diagnosisCo-occurring SUDSubstance use disorder diagnosisSubstance use disordersDSM-5 criteriaSemi-Structured AssessmentAnxiety disorder diagnosisLifetime SUDMild severityUse disordersDrug dependenceSevere disordersDSM-IVPercent agreementDiagnosisAnxiety disordersLifetime alcoholLimited evidenceDisorders
2014
Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort
Kalayasiri R, Verachai V, Gelernter J, Mutirangura A, Malison RT. Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort. Addiction 2014, 109: 965-976. PMID: 24521142, PMCID: PMC4018411, DOI: 10.1111/add.12512.Peer-Reviewed Original ResearchConceptsDopamine β-hydroxylaseMethamphetamine-dependent individualsAssociated clinical variablesGenetic polymorphismsΒ-hydroxylaseLogistic regression analysisSubstance abuse treatment centersHigh-activity genotypesSemi-Structured AssessmentAntisocial personality disorderCT carriersCent of individualsClinical featuresClinical presentationCigarette smokingClinical variablesRetrospective analysisTreatment centersDrug dependenceActivity genotypeMethamphetamine useMethamphetamine dependencePersonality disorderRegression analysisGenetic association
2012
Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample
Peer K, Rennert L, Lynch KG, Farrer L, Gelernter J, Kranzler HR. Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample. Drug And Alcohol Dependence 2012, 127: 215-219. PMID: 22884164, PMCID: PMC3727225, DOI: 10.1016/j.drugalcdep.2012.07.009.Peer-Reviewed Original ResearchConceptsSubstance use disordersSUD diagnosisDSM-IVDiagnosis of SUDDSM-5DSM-5 substance use disordersDSM-5 SUD diagnosesDiagnostic orphansSevere substance use disordersLimited diagnostic utilityDSM-5 diagnosisDSM-5 alcoholSemi-Structured AssessmentDSM-IV abuseDiagnostic switchLifetime presenceClinical careDiagnostic criteriaGreater prevalenceUse disordersDiagnostic utilityDependence diagnosisMental disordersDrug dependenceSubstance dependence
2011
Empirically derived subtypes of opioid use and related behaviors
Chan G, Gelernter J, Oslin D, Farrer L, Kranzler HR. Empirically derived subtypes of opioid use and related behaviors. Addiction 2011, 106: 1146-1154. PMID: 21306596, PMCID: PMC3164489, DOI: 10.1111/j.1360-0443.2011.03390.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAgedAnalgesics, OpioidChildCluster AnalysisComorbidityDiagnostic and Statistical Manual of Mental DisordersFamily HealthFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInterview, PsychologicalMaleMental DisordersMiddle AgedOpioid-Related DisordersPhenotypePrevalenceSiblingsSubstance Abuse, IntravenousUnited StatesYoung AdultConceptsOpioid usePsychiatric disordersHomogeneous subtypesRelated behaviorsSemi-Structured AssessmentGeneral community sampleOpioid dependenceMedical historyPrevalence ratesCocaine dependenceDrug dependenceSubtypesParticipant demographicsSubstance useCase-control genetic studyDemographicsDisordersCommunity sampleGenetic studiesInter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
Malison RT, Kalayasiri R, Sanichwankul K, Sughondhabirom A, Mutirangura A, Pittman B, Gueorguieva R, Kranzler HR, Gelernter J. Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Addictive Behaviors 2011, 36: 156-160. PMID: 20888699, PMCID: PMC2981662, DOI: 10.1016/j.addbeh.2010.08.031.Peer-Reviewed Original Research
2009
Adolescent cannabis use increases risk for cocaine-induced paranoia
Kalayasiri R, Gelernter J, Farrer L, Weiss R, Brady K, Gueorguieva R, Kranzler HR, Malison RT. Adolescent cannabis use increases risk for cocaine-induced paranoia. Drug And Alcohol Dependence 2009, 107: 196-201. PMID: 19944543, PMCID: PMC2821949, DOI: 10.1016/j.drugalcdep.2009.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAge FactorsAge of OnsetCannabisCatechol O-MethyltransferaseCocaine-Related DisordersFemaleGene FrequencyGenetic Predisposition to DiseaseHumansLogistic ModelsMaleParanoid DisordersPolymerase Chain ReactionPrevalencePsychiatric Status Rating ScalesRisk FactorsSeverity of Illness IndexSiblingsUnited StatesConceptsAdolescent onset cannabisEarly cannabis exposureCocaine-dependent individualsCocaine-induced paranoiaCannabis exposureRisk factorsCOMT genotypeSemi-Structured AssessmentCatechol-O-methyl transferase (COMT) geneCOMT Val158Met genotypeCannabis abuseIncrease riskPsychotic symptomsOnset interactionPsychotic disordersStimulant abuseDrug dependenceFamily-based studyLogistic regressionEarly exposureAdolescent cannabisCannabisGenetic factorsSignificant predictorsVal158Met genotypeInteractive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations
Xie P, Kranzler HR, Poling J, Stein MB, Anton RF, Brady K, Weiss RD, Farrer L, Gelernter J. Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations. JAMA Psychiatry 2009, 66: 1201-1209. PMID: 19884608, PMCID: PMC2867334, DOI: 10.1001/archgenpsychiatry.2009.153.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlack or African AmericanChildChild AbuseCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleGenetic Predisposition to DiseaseGenotypeHomozygoteHumansLife Change EventsMaleMiddle AgedPolymorphism, GeneticPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSocial EnvironmentStress Disorders, Post-TraumaticSubstance-Related DisordersWhite PeopleConceptsAdult traumatic eventsPosttraumatic stress disorderLifetime posttraumatic stress disorderChildhood adversityStressful life eventsTraumatic eventsDSM-IV diagnostic criteriaOnset of PTSDCross-sectional studyStress disorder diagnosisPosttraumatic stress disorder (PTSD) diagnosisLogistic regression modelingLife eventsSemi-Structured AssessmentEtiology of PTSDAdverse eventsAfrican American individualsDepressive symptomsDiagnostic criteriaSerotonin transporter geneDrug dependenceTrauma exposureStress disorderGene x environment interactionsSubstance dependenceSubtypes of major depression in substance dependence
Niciu MJ, Chan G, Gelernter J, Arias AJ, Douglas K, Weiss R, Anton RF, Farrer L, Cubells JF, Kranzler HR. Subtypes of major depression in substance dependence. Addiction 2009, 104: 1700-1709. PMID: 19681804, PMCID: PMC2980795, DOI: 10.1111/j.1360-0443.2009.02672.x.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdolescentAdultAge FactorsAnxiety DisordersBlack or African AmericanComorbidityData Interpretation, StatisticalDepressive Disorder, MajorFemaleHispanic or LatinoHumansInterview, PsychologicalLogistic ModelsMaleRecurrenceSocioeconomic FactorsSubstance-Related DisordersSuicide, AttemptedWhite PeopleYoung AdultConceptsMajor depressive episodeSubstance dependenceMDE subtypesDrug dependenceRelated clinical featuresPotential therapeutic implicationsSubstance use disordersAcademic medical centerGreater psychiatric severitySemi-Structured AssessmentClinical featuresDepressive episodeMajor depressionMedical CenterSecondary data analysisDepressive symptomsDiagnostic criteriaPsychiatric severityTherapeutic implicationsUse disordersSubtypesAnxiety disordersPsychiatric measuresCase-control genetic studyCommunity recruitmentAdverse childhood events as risk factors for substance dependence: Partial mediation by mood and anxiety disorders
Douglas KR, Chan G, Gelernter J, Arias AJ, Anton RF, Weiss RD, Brady K, Poling J, Farrer L, Kranzler HR. Adverse childhood events as risk factors for substance dependence: Partial mediation by mood and anxiety disorders. Addictive Behaviors 2009, 35: 7-13. PMID: 19720467, PMCID: PMC2763992, DOI: 10.1016/j.addbeh.2009.07.004.Peer-Reviewed Original ResearchConceptsAdverse childhood eventsSD riskSubstance dependenceAnxiety disordersRisk factorsNegative health outcomesSemi-Structured AssessmentChildhood eventsOpioid dependenceSD diagnosisLifetime moodEffective treatmentLifetime diagnosisFirst onsetHealth outcomesDrug dependenceEarly life experiencesDisordersChildhood abuseRiskMoodDiagnosisAlcoholismCocaineSources of unreliability in the diagnosis of substance dependence.
Feinn R, Gelernter J, Cubells JF, Farrer L, Kranzler HR. Sources of unreliability in the diagnosis of substance dependence. Journal Of Studies On Alcohol And Drugs 2009, 70: 475-81. PMID: 19371499, PMCID: PMC2670752, DOI: 10.15288/jsad.2009.70.475.Peer-Reviewed Original ResearchConceptsSubstance dependence diagnosesDrug dependenceCommon diagnosisCriterion countsSemi-Structured AssessmentOpioid dependencePsychiatric disordersMost diagnosesOccasion variabilityMental disordersSubstance dependenceDiagnosisStatistical ManualMarijuana dependenceReliable diagnosisFourth EditionDependence categoriesSubjects' reportsSubjectsExcellent reliabilityDisordersCountIndex of dependabilityReportInterviewers
2008
Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals
Ford JD, Gelernter J, DeVoe JS, Zhang W, Weiss RD, Brady K, Farrer L, Kranzler HR. Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals. Drug And Alcohol Dependence 2008, 99: 193-203. PMID: 18775607, PMCID: PMC2745327, DOI: 10.1016/j.drugalcdep.2008.07.004.Peer-Reviewed Original ResearchConceptsCocaine dependence severitySubstance use disordersTreatment utilizationSelf-help group participationDependence severityPsychiatric disordersUse disordersCo-occurring substance dependenceMajor depressive disorderSubstance dependence disordersAssociation of psychiatricLogistic regression analysisCocaine dependence treatmentPosttraumatic stress disorderSemi-Structured AssessmentAntisocial personality disorderHeavy cocaine useClinical managementDependence treatmentDepressive disorderDisorder comorbidityService utilizationCocaine-dependent individualsDependence disordersBipolar disorderCorrelates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders
Arias AJ, Gelernter J, Chan G, Weiss RD, Brady KT, Farrer L, Kranzler HR. Correlates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders. Addictive Behaviors 2008, 33: 1199-1207. PMID: 18558465, PMCID: PMC2532519, DOI: 10.1016/j.addbeh.2008.05.003.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderFirst substance useOpioid dependenceLifetime diagnosisSubstance useCo-occurring attention-deficit hyperactivity disorderSubstance dependence disordersDrug-dependent subjectsSemi-Structured AssessmentDeficit hyperactivity disorderClinical courseMore hospitalizationsSevere coursePsychiatric comorbiditySD diagnosisDependence disordersPsychiatric disordersADHD prevalencePsychiatric diagnosisDrug dependenceMore SDsSubstance dependenceConduct disorderDiagnosisHyperactivity disorder