2010
Cellular Maintenance and Repair of the Kidney
Guo JK, Cantley LG. Cellular Maintenance and Repair of the Kidney. Annual Review Of Physiology 2010, 72: 357-376. PMID: 20148680, DOI: 10.1146/annurev.physiol.010908.163245.Peer-Reviewed Original ResearchConceptsMultiple cell typesBone marrow-derived stemPrecise structural arrangementCellular maintenanceEx vivo programmingRenal lineagesAdult organsMammalian kidneyCell typesStem cellsProgenitor cellsComplex organRepair processCurrent understandingCell viabilityCellsFunctional stabilityCompartmentsLineagesCell injuryMaintenanceVivo programmingStructural arrangementOrgansActive reabsorption
2002
WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
Guo JK, Menke AL, Gubler MC, Clarke AR, Harrison D, Hammes A, Hastie ND, Schedl A. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Human Molecular Genetics 2002, 11: 651-659. PMID: 11912180, DOI: 10.1093/hmg/11.6.651.Peer-Reviewed Original ResearchConceptsTumor 1 geneExpression levelsWilms' tumor 1 geneMesangial sclerosisYeast artificial chromosome transgenic mouse modelWT1 resultsDistinct renal diseasesGenetic evidenceDenys-Drash patientsGene dosageCrescentic glomerulonephritisKey regulatorMolecular explanationDominant mutationsEnd-stage renal failureCell typesPodocyte functionGenes NPHS1WAGR syndromeLevel of WT1Transgenic mouse modelWT1GenesGlomerular basement membraneRenal failure