Early Gonadal Development: Exploring Wt1 and Sox9 Function
Guo J, Hammes A, Chaboissier M, Vidal V, Xing Y, Wong F, Schedl A. Early Gonadal Development: Exploring Wt1 and Sox9 Function. Novartis Foundation Symposia 2002, 244: 23-34. PMID: 11990794, DOI: 10.1002/0470868732.ch3.Peer-Reviewed Original ResearchConceptsSox9 functionSex determinationSex-determining gene SRYSex-determining signalWilms' tumor suppressorFemale sex reversalBipotential primordiumGonad formationGene SRYXX gonadsTransgenic experimentsFirst geneGonadal primordiumMouse developmentPosttranscriptional modificationsKnockout experimentsSex reversalHuman SOX9Distinct functionsSRY geneGonadal anlageSOX9 geneTumor suppressorImportant regulatorGenesWT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
Guo JK, Menke AL, Gubler MC, Clarke AR, Harrison D, Hammes A, Hastie ND, Schedl A. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Human Molecular Genetics 2002, 11: 651-659. PMID: 11912180, DOI: 10.1093/hmg/11.6.651.Peer-Reviewed Original ResearchConceptsTumor 1 geneExpression levelsWilms' tumor 1 geneMesangial sclerosisYeast artificial chromosome transgenic mouse modelWT1 resultsDistinct renal diseasesGenetic evidenceDenys-Drash patientsGene dosageCrescentic glomerulonephritisKey regulatorMolecular explanationDominant mutationsEnd-stage renal failureCell typesPodocyte functionGenes NPHS1WAGR syndromeLevel of WT1Transgenic mouse modelWT1GenesGlomerular basement membraneRenal failure