1993
The Therapeutic Potential of Neurotrophic Factors in the Treatment of Parkinson's Disease
Lindsay R, Altar C, Cedarbaum J, Hyman C, Wiegand S. The Therapeutic Potential of Neurotrophic Factors in the Treatment of Parkinson's Disease. Experimental Neurology 1993, 124: 103-118. PMID: 8282068, DOI: 10.1006/exnr.1993.1181.Peer-Reviewed Original ResearchConceptsNeurotrophic factorParkinson's diseaseNeurodegenerative disordersTherapeutic agentsNeurodegenerative diseasesFetal nigral graftsTransplantation of neuronsDopamine neurotrophic factorPartial symptomatic reliefDopamine receptor agonistsNeurotrophic growth factorsPotential clinical useHuman neurodegenerative disordersAppropriate neurotransmittersObvious therapeutic strategyNeuronal lossNigral graftsSymptomatic reliefDevelopment of drugsDopaminergic neuronsNeuroprotective agentsSubstantia nigraNeuronal degenerationNeurotrophin familyDopamine neurons
1978
Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique
Cedarbaum J, Aghajanian G. Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. The Journal Of Comparative Neurology 1978, 178: 1-15. PMID: 632368, DOI: 10.1002/cne.901780102.Peer-Reviewed Original ResearchConceptsLocus coeruleusRat locus coeruleusCentral gray substanceLateral hypothalamic areaRetrograde tracing techniquesLateral reticular nucleusCatecholamine cell groups A1Magnocellular preoptic areaSingle-cell recordingsDorsal hornReactive neuronsNoradrenergic neuronsSolitary tractAfferent innervationLabeled neuronsHypothalamic areaReticular nucleusHRP injectionsPreoptic areaSpinal cordInsular cortexAfferent projectionsGray substanceReticular formationAfferent connections
1977
Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization
Cedarbaum J, Aghajanian G. Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization. European Journal Of Pharmacology 1977, 44: 375-385. PMID: 330174, DOI: 10.1016/0014-2999(77)90312-0.Peer-Reviewed Original ResearchConceptsLC neuronsLocus coeruleusNoradrenergic neuronsCatecholamine receptorsΑ-receptorsCell bodiesΑ-methylnorepinephrinePostsynaptic α-receptorsPeripheral sympathetic nervesLocus coeruleus neuronsDopamine agonist apomorphineCentral dopamine receptorsΒ-agonist isoproterenolSingle-unit recordingsSympathetic nervesAgonist apomorphineAgonist clonidineMicroiontophoretic applicationCoeruleus neuronsSpontaneous firingΑ-adrenoreceptorsDopamine receptorsPharmacological characterizationAgonist drugsPharmacological characteristics