1998
Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat
Cliffer K, Siuciak J, Carson S, Radley H, Park J, Lewis D, Zlotchenko E, Nguyen T, Garcia K, Tonra J, Stambler N, Cedarbaum J, Bodine S, Lindsay R, Distefano P. Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat. Annals Of Neurology 1998, 43: 46-55. PMID: 9450768, DOI: 10.1002/ana.410430111.Peer-Reviewed Original ResearchConceptsLarge-fiber sensory neuropathySensory neuropathyGeneral healthSensory compound nerve action potentialMature ratsCompound nerve action potentialSensory conduction velocityForelimb grip strengthSevere axonal degenerationNerve action potentialsFrequency of dosingH-wave amplitudeAbility of ratsMotor amplitudeDosing schedulesPeripheral neuropathyAxonal degenerationDorsal rootsProprioceptive deficitsClinical syndromeMuscle strengthGrip strengthHeat nociceptionVentral rootsChemotherapeutic agent taxol
1996
Treatment with ciliary neurotrophic factor does not improve regeneration in experimental autoimmune neuritis of the Lewis rat
Gold R, Zielasek J, Schröder J, Sellhaus B, Cedarbaum J, Hartung H, Sendtner M, Toyka K. Treatment with ciliary neurotrophic factor does not improve regeneration in experimental autoimmune neuritis of the Lewis rat. Muscle & Nerve 1996, 19: 1177-1180. PMID: 8761279, DOI: 10.1002/(sici)1097-4598(199609)19:9<1177::aid-mus17>3.0.co;2-s.Peer-Reviewed Original ResearchRe: Pharmacokinetics and pharmacodynamics of rHCNTF in rodents
Cedarbaum J, Distcfano P, Lakings D, Lindsay R. Re: Pharmacokinetics and pharmacodynamics of rHCNTF in rodents. Annals Of Neurology 1996, 39: 552-553. PMID: 8619536, DOI: 10.1002/ana.410390420.Peer-Reviewed Original Research
1988
Clinical significance of the relationship between O-methyldopa levels and levodopa intake.
Cedarbaum J, Kutt H, McDowell F. Clinical significance of the relationship between O-methyldopa levels and levodopa intake. Neurology 1988, 38: 533-6. PMID: 3352906, DOI: 10.1212/wnl.38.4.533.Peer-Reviewed Original ResearchConceptsDaily intakeRecent clinical trialsMean daily intakeTotal daily intakeLevodopa intakeStandard SinemetClinical responseLevodopa preparationsBrain uptakeClinical trialsPlasma concentrationsClinical significanceBlood samplingLevodopaTherapeutic efficacyMethyldopa levelsControlled-release formulationPatientsIntakeTime curveAUCSinemetLevelsTrials
1978
Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism
Cedarbaum J, Aghajanian G. Activation of locus coeruleus neurons by peripheral stimuli: Modulation by a collateral inhibitory mechanism. Life Sciences 1978, 23: 1383-1392. PMID: 214648, DOI: 10.1016/0024-3205(78)90398-3.Peer-Reviewed Original ResearchConceptsLocus coeruleusNerve stimulationLocus coeruleus neuronsRat locus coeruleusPeripheral nerve stimulationBursts of spikesNeuronal responsivityNoradrenergic neuronsCoeruleus neuronsAntidromic activationAxon collateralsAdrenergic antagonistsPutative transmittersNoxious stimuliPeripheral stimuliUnit firingReduced responsivityAutoinhibitory actionInhibitory mechanismPiperoxaneNeuronsAdditional stimulusStimulationCollateralsStimuliAfferent projections to the rat locus coeruleus as determined by a retrograde tracing technique
Cedarbaum J, Aghajanian G. Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. The Journal Of Comparative Neurology 1978, 178: 1-15. PMID: 632368, DOI: 10.1002/cne.901780102.Peer-Reviewed Original ResearchConceptsLocus coeruleusRat locus coeruleusCentral gray substanceLateral hypothalamic areaRetrograde tracing techniquesLateral reticular nucleusCatecholamine cell groups A1Magnocellular preoptic areaSingle-cell recordingsDorsal hornReactive neuronsNoradrenergic neuronsSolitary tractAfferent innervationLabeled neuronsHypothalamic areaReticular nucleusHRP injectionsPreoptic areaSpinal cordInsular cortexAfferent projectionsGray substanceReticular formationAfferent connections
1977
Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons
Aghajanian GK, Cedarbaum JM, Wang RY. Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Research 1977, 136: 570-577. PMID: 922502, DOI: 10.1016/0006-8993(77)90083-x.Peer-Reviewed Original ResearchCatecholamine receptors on locus coeruleus neurons: Pharmacological characterization
Cedarbaum J, Aghajanian G. Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization. European Journal Of Pharmacology 1977, 44: 375-385. PMID: 330174, DOI: 10.1016/0014-2999(77)90312-0.Peer-Reviewed Original ResearchConceptsLC neuronsLocus coeruleusNoradrenergic neuronsCatecholamine receptorsΑ-receptorsCell bodiesΑ-methylnorepinephrinePostsynaptic α-receptorsPeripheral sympathetic nervesLocus coeruleus neuronsDopamine agonist apomorphineCentral dopamine receptorsΒ-agonist isoproterenolSingle-unit recordingsSympathetic nervesAgonist apomorphineAgonist clonidineMicroiontophoretic applicationCoeruleus neuronsSpontaneous firingΑ-adrenoreceptorsDopamine receptorsPharmacological characterizationAgonist drugsPharmacological characteristicsEffects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats
Davis M, Cedarbaum J, Aghajanian G, Gendelman D. Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats. Psychopharmacology 1977, 51: 243-253. PMID: 403539, DOI: 10.1007/bf00431631.Peer-Reviewed Original Research
1976
Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane
Cedarbaum J, Aghajanian G. Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane. Brain Research 1976, 112: 413-419. PMID: 8191, DOI: 10.1016/0006-8993(76)90297-3.Peer-Reviewed Original Research