1998
Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat
Cliffer K, Siuciak J, Carson S, Radley H, Park J, Lewis D, Zlotchenko E, Nguyen T, Garcia K, Tonra J, Stambler N, Cedarbaum J, Bodine S, Lindsay R, Distefano P. Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat. Annals Of Neurology 1998, 43: 46-55. PMID: 9450768, DOI: 10.1002/ana.410430111.Peer-Reviewed Original ResearchConceptsLarge-fiber sensory neuropathySensory neuropathyGeneral healthSensory compound nerve action potentialMature ratsCompound nerve action potentialSensory conduction velocityForelimb grip strengthSevere axonal degenerationNerve action potentialsFrequency of dosingH-wave amplitudeAbility of ratsMotor amplitudeDosing schedulesPeripheral neuropathyAxonal degenerationDorsal rootsProprioceptive deficitsClinical syndromeMuscle strengthGrip strengthHeat nociceptionVentral rootsChemotherapeutic agent taxol
1995
Effects of brain‐derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
Ikeda K, Klinkosz B, Greene T, Cedarbaum J, Wong V, Lindsay R, Mitsumoto H. Effects of brain‐derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Annals Of Neurology 1995, 37: 505-511. PMID: 7717687, DOI: 10.1002/ana.410370413.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorMouse motor neuron diseaseWobbler mouse motor neuron diseaseMotor neuron diseaseBDNF treatmentMotor dysfunctionNeurotrophic factorNeuron diseaseVentral rootsMotor neuronsWobbler miceExogenous brain-derived neurotrophic factorAxotomy-induced cell deathHuman brain-derived neurotrophic factorBDNF-treated miceBiceps muscle weightCervical ventral rootsDenervation muscle atrophyExogenous BDNF administrationMotor axon lossRecombinant human brain-derived neurotrophic factorVehicle-treated miceVehicle-treated animalsEnd of treatmentMuscle twitch tensionHistometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease
Ikeda K, Wong V, Holmlund T, Greene T, Cedarbaum J, Lindsay R, Mitsumoto H. Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease. Annals Of Neurology 1995, 37: 47-54. PMID: 7818257, DOI: 10.1002/ana.410370110.Peer-Reviewed Original ResearchConceptsCiliary neurotrophic factorMotor neuron diseaseNeurotrophic factorMotor neuronsHuman ciliary neurotrophic factorNeuron diseaseWobbler miceWobbler mouse motor neuron diseaseMouse motor neuron diseaseCalcitonin gene-related peptideAcute axonal degenerationAxonal branching pointsBiceps muscle weightC5 ventral rootsGene-related peptidePercentage of axonsAtrophied muscle fibersUntreated control groupRat ciliary neurotrophic factorMean muscle fiber diameterMusculocutaneous nerveAxonal degenerationVentral rootsSubcutaneous injectionVacuolar degeneration