Validating New Symptom Emergence as a Patient-Centric Outcome Measure for PD Clinical Trials
Zou H, Stebbins G, Simuni T, Luo S, Cedarbaum J. Validating New Symptom Emergence as a Patient-Centric Outcome Measure for PD Clinical Trials. Parkinsonism & Related Disorders 2024, 107118. DOI: 10.1016/j.parkreldis.2024.107118.Peer-Reviewed Original ResearchPD clinical trialsClinical trialsEmergent symptomsPhase 3 clinical trialsPhase 3 studySlowing of disease progressionOutcome measuresParkinson's diseaseDe novo Parkinson's diseaseMDS-UPDRSItem-level dataFrequency of ESSymptomatic medicationsFrequent administrationMonths of observationEfficacy assessmentDisease progressionSymptom emergenceRating ScaleItem responsesIb and IIUrate elevationTrials