2012
Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis
Shefner J, Cedarbaum JM, Cudkowicz ME, Maragakis N, Lee J, Jones D, Watson ML, Mahoney K, Chen M, Saikali K, Mao J, Russell AJ, Hansen RL, Malik F, Wolff AA, Team F. Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2012, 13: 430-438. PMID: 22591195, DOI: 10.3109/17482968.2012.684214.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisSingle dosesGlobal ImpressionLateral sclerosisFast skeletal muscle troponin activatorFrequent adverse eventsDose-related fashionLimb muscle strengthMaximum voluntary ventilationDose-dependent benefitMeasures of enduranceAdverse eventsPulmonary functionVoluntary ventilationGeneral fatigueTroponin activatorMuscle strengthPharmacodynamic markersHandgrip endurancePatientsRandom orderMaximal strengthDosesTolerabilityFurther studies
1998
Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat
Cliffer K, Siuciak J, Carson S, Radley H, Park J, Lewis D, Zlotchenko E, Nguyen T, Garcia K, Tonra J, Stambler N, Cedarbaum J, Bodine S, Lindsay R, Distefano P. Physiological characterization of taxol‐induced large‐fiber sensory neuropathy in the rat. Annals Of Neurology 1998, 43: 46-55. PMID: 9450768, DOI: 10.1002/ana.410430111.Peer-Reviewed Original ResearchConceptsLarge-fiber sensory neuropathySensory neuropathyGeneral healthSensory compound nerve action potentialMature ratsCompound nerve action potentialSensory conduction velocityForelimb grip strengthSevere axonal degenerationNerve action potentialsFrequency of dosingH-wave amplitudeAbility of ratsMotor amplitudeDosing schedulesPeripheral neuropathyAxonal degenerationDorsal rootsProprioceptive deficitsClinical syndromeMuscle strengthGrip strengthHeat nociceptionVentral rootsChemotherapeutic agent taxol
1994
The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
Mitsumoto H, Ikeda K, Holmlund T, Greene T, Cedarbaum J, Wong V, Lindsay R. The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Annals Of Neurology 1994, 36: 142-148. PMID: 8053649, DOI: 10.1002/ana.410360205.Peer-Reviewed Original ResearchConceptsCiliary neurotrophic factorNeurotrophic factorMotor neuron diseaseHuman ciliary neurotrophic factorGrip strengthNeuron diseaseBody weightWobbler mouse motor neuron diseaseMotor neuron disease modelMouse motor neuron diseaseFirst neurotrophic factorMean grip strengthImproved muscle strengthVehicle-treated animalsWeeks of treatmentMuscle twitch tensionSurvival-promoting effectsWobbler mouse modelRat ciliary neurotrophic factorMotor dysfunctionControl miceMuscle strengthDisease progressionMotor neuronsTwitch tension