2011
Improvements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarction
2009
National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance
Bradley EH, Nallamothu BK, Herrin J, Ting HH, Stern AF, Nembhard IM, Yuan CT, Green JC, Kline-Rogers E, Wang Y, Curtis JP, Webster TR, Masoudi FA, Fonarow GC, Brush JE, Krumholz HM. National Efforts to Improve Door-to-Balloon Time Results From the Door-to-Balloon Alliance. Journal Of The American College Of Cardiology 2009, 54: 2423-2429. PMID: 20082933, DOI: 10.1016/j.jacc.2009.11.003.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionD2B AllianceBalloon (D2B) AllianceHospital presentationD2B timeNational Cardiovascular Data Registry CathPCI RegistryPrimary percutaneous coronary interventionElevation myocardial infarctionPercutaneous coronary interventionLikelihood of patientsCathPCI RegistryCoronary interventionBalloon timeMyocardial infarctionAmerican CollegePatientsHospitalLongitudinal studyNational Quality CampaignOne-halfPresentationMinNational effortsInfarctionRegistry
2007
Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Herrin J, Wang Y, Curtis JP, Bradley EH, Magid DJ, Rathore SS, Nallamothu BK, Peterson ED, Blaney ME, Frederick P, Krumholz HM. Impact of Delay in Door-to-Needle Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2007, 100: 1227-1232. PMID: 17920362, PMCID: PMC2715362, DOI: 10.1016/j.amjcard.2007.05.043.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArrhythmias, CardiacCaliforniaCohort StudiesEmergency Service, HospitalEmergency TreatmentFemaleFibrinolytic AgentsHospital MortalityHumansMaleMedical RecordsMyocardial InfarctionOutcome Assessment, Health CareRegistriesRetrospective StudiesThrombolytic TherapyTime and Motion StudiesTime FactorsConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionNeedle timeFibrinolytic therapyMyocardial infarctionHospital mortalitySymptom onsetOdds ratioReperfusion strategyAdjunctive medicationsHospital arrivalShorter doorTimely administrationNational registryRepresentative cohortPatientsMortalityInfarctionTherapyIndependent effectsCohortMinutesSmaller centersOnsetImpact of delay
2006
Door-to-drug and door-to-balloon times: Where can we improve? Time to reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI)
Bradley EH, Herrin J, Wang Y, McNamara RL, Radford MJ, Magid DJ, Canto JG, Blaney M, Krumholz HM. Door-to-drug and door-to-balloon times: Where can we improve? Time to reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI). American Heart Journal 2006, 151: 1281-1287. PMID: 16781237, DOI: 10.1016/j.ahj.2005.07.015.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPatients' clinical characteristicsBalloon timeClinical characteristicsDrug timeMyocardial infarctionProportion of patientsElevation myocardial infarctionHospital-level variationTreatment of patientsCross-sectional analysisHigh performing hospitalsReperfusion therapyNational registryHospitalPatientsRegression modelingECGDrugsInfarctionHierarchical regression modelingHospital performanceImportant quality indicatorMinutesGeometric meanEffect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction
McNamara RL, Wang Y, Herrin J, Curtis JP, Bradley EH, Magid DJ, Peterson ED, Blaney M, Frederick PD, Krumholz HM, Investigators N. Effect of Door-to-Balloon Time on Mortality in Patients With ST-Segment Elevation Myocardial Infarction. Journal Of The American College Of Cardiology 2006, 47: 2180-2186. PMID: 16750682, DOI: 10.1016/j.jacc.2005.12.072.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionBalloon timeElevation myocardial infarctionSymptom onsetMyocardial infarctionHospital mortalityPatient characteristicsDoor timeEffect of doorPrimary PCIBaseline risk statusPercutaneous coronary interventionHigh-risk factorsSTEMI patientsCohort studyCoronary interventionLonger doorEntire cohortSubgroup analysisNational registryBaseline riskMortality riskPatientsMortalityThe Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000–2002 Findings From the National Registry of Myocardial Infarction-4
Curtis JP, Portnay EL, Wang Y, McNamara RL, Herrin J, Bradley EH, Magid DJ, Blaney ME, Canto JG, Krumholz HM. The Pre-Hospital Electrocardiogram and Time to Reperfusion in Patients With Acute Myocardial Infarction, 2000–2002 Findings From the National Registry of Myocardial Infarction-4. Journal Of The American College Of Cardiology 2006, 47: 1544-1552. PMID: 16630989, DOI: 10.1016/j.jacc.2005.10.077.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPre-hospital electrocardiogramPrimary percutaneous coronary interventionMyocardial infarction 4Mean doorReperfusion timeHospital characteristicsNational registryTreatment of STEMILimited contemporary informationElevation myocardial infarctionPercutaneous coronary interventionBundle branch blockAcute reperfusionECG usePCI cohortReperfusion therapyBalloon timeCoronary interventionFibrinolytic therapyTherapy cohortMyocardial infarctionBranch blockNational guidelinesDrug timeRelation Between Hospital Specialization With Primary Percutaneous Coronary Intervention and Clinical Outcomes in ST-Segment Elevation Myocardial Infarction
Nallamothu BK, Wang Y, Magid DJ, McNamara RL, Herrin J, Bradley EH, Bates ER, Pollack CV, Krumholz HM. Relation Between Hospital Specialization With Primary Percutaneous Coronary Intervention and Clinical Outcomes in ST-Segment Elevation Myocardial Infarction. Circulation 2006, 113: 222-229. PMID: 16401769, DOI: 10.1161/circulationaha.105.578195.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionHospital mortalityBalloon timePPCI volumeFibrinolytic therapyClinical outcomesMyocardial infarctionPrimary percutaneous coronary intervention capabilityPercutaneous coronary intervention capabilityPrimary percutaneous coronary interventionHierarchical multivariable regressionMyocardial infarction 4Hospital-level factorsPercutaneous coronary interventionHospital specializationSTEMI patientsCoronary interventionHighest quartileShorter doorHospital characteristicsNational registryLowest quartileRelative riskMultivariable regression
2005
Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002
McNamara RL, Herrin J, Bradley EH, Portnay EL, Curtis JP, Wang Y, Magid DJ, Blaney M, Krumholz HM, Investigators N. Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002. Journal Of The American College Of Cardiology 2005, 47: 45-51. PMID: 16386663, PMCID: PMC1475926, DOI: 10.1016/j.jacc.2005.04.071.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionBalloon timeMin/yearNeedle timeMyocardial infarctionHospital characteristicsAcute ST-segment elevation myocardial infarctionPercutaneous coronary intervention cohortPercutaneous coronary intervention volumeElevation myocardial infarctionPercutaneous coronary interventionRetrospective observational studyFour-year study periodRapid reperfusionCoronary interventionFibrinolytic therapyHospital arrivalTherapy cohortReperfusion timeIntervention cohortNational registryIntervention volumeObservational studyHospital improvementPatientsRelationship Between Time of Day, Day of Week, Timeliness of Reperfusion, and In-Hospital Mortality for Patients With Acute ST-Segment Elevation Myocardial Infarction
Magid DJ, Wang Y, Herrin J, McNamara RL, Bradley EH, Curtis JP, Pollack CV, French WJ, Blaney ME, Krumholz HM. Relationship Between Time of Day, Day of Week, Timeliness of Reperfusion, and In-Hospital Mortality for Patients With Acute ST-Segment Elevation Myocardial Infarction. JAMA 2005, 294: 803-812. PMID: 16106005, DOI: 10.1001/jama.294.7.803.Peer-Reviewed Original ResearchMeSH KeywordsAdultAfter-Hours CareAgedAged, 80 and overAngioplasty, Balloon, CoronaryBenchmarkingChronology as TopicFemaleHospital MortalityHospitalsHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionRegistriesRetrospective StudiesThrombolytic TherapyTime and Motion StudiesTime FactorsUnited StatesUtilization ReviewConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionElevation myocardial infarctionBalloon timeFibrinolytic therapyHospital mortalityMyocardial infarctionAcute ST-segment elevation myocardial infarctionDrug timeRegular hoursTimeliness of reperfusionIn-Hospital MortalityDay of weekPCI patientsReperfusion therapyCohort studyCoronary interventionMean doorHospital characteristicsCatheterization laboratoryBetter outcomesPatientsHospital subgroupsTherapyPatient arrivalTimes to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States
Nallamothu BK, Bates ER, Herrin J, Wang Y, Bradley EH, Krumholz HM. Times to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States. Circulation 2005, 111: 761-767. PMID: 15699253, DOI: 10.1161/01.cir.0000155258.44268.f8.Peer-Reviewed Original ResearchConceptsPrimary PCIPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionPercutaneous coronary interventionBalloon timeTransfer patientsCoronary interventionInterhospital transferMyocardial infarctionTotal doorRecent clinical trialsSpecific ECG findingsMultivariable hierarchical modelsChest painHospital presentationInitial hospitalFibrinolytic therapyPCI hospitalsPrimary outcomeSymptom onsetComorbid conditionsTreatment delayECG findingsHospital characteristicsNational registry
2004
Racial and Ethnic Differences in Time to Acute Reperfusion Therapy for Patients Hospitalized With Myocardial Infarction
Bradley EH, Herrin J, Wang Y, McNamara RL, Webster TR, Magid DJ, Blaney M, Peterson ED, Canto JG, Pollack CV, Krumholz HM. Racial and Ethnic Differences in Time to Acute Reperfusion Therapy for Patients Hospitalized With Myocardial Infarction. JAMA 2004, 292: 1563-1572. PMID: 15467058, DOI: 10.1001/jama.292.13.1563.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryAsian PeopleBlack PeopleFemaleHispanic or LatinoHospitalsHumansInsurance, HospitalizationMaleMiddle AgedMyocardial InfarctionOutcome Assessment, Health CarePatient AdmissionRetrospective StudiesSocioeconomic FactorsThrombolytic TherapyTime and Motion StudiesTime FactorsUnited StatesWhite PeopleConceptsST-segment elevation myocardial infarctionAcute reperfusion therapyElevation myocardial infarctionMyocardial infarctionReperfusion therapyAfrican American/BlackBalloon timeInsurance statusAmerican/BlackEthnic differencesPercutaneous coronary interventionBundle branch blockAsian/Pacific IslandersHealth care disparitiesRace/ethnicity differencesRace/ethnicityClinical characteristicsCoronary interventionFibrinolytic therapyHospital arrivalNonwhite patientsPrimary reperfusionWhite patientsUS cohortHospital characteristics