2011
Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats
Cao J, Dwyer JB, Mangold JE, Wang J, Wei J, Leslie FM, Li MD. Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats. The International Journal Of Neuropsychopharmacology 2011, 14: 157-174. PMID: 20196919, PMCID: PMC5575906, DOI: 10.1017/s1461145710000179.Peer-Reviewed Original ResearchConceptsGestational nicotine treatmentLimbic brain regionsCell adhesion moleculePsychiatric disordersBrain regionsPregnant Sprague-Dawley ratsGestational day 4Prenatal nicotine exposureNicotine replacement therapyPostnatal day 35Sprague-Dawley ratsMajor psychoactive componentAdolescent female ratsCentral nervous systemQuantitative RT-PCR techniqueRT-PCR techniqueMaternal smokingNicotine treatmentNicotine exposureReplacement therapyCaudate putamenFemale ratsPrenatal treatmentNeurotransmitter systemsNeurobehavioural deficits
2009
The dynamic effects of nicotine on the developing brain
Dwyer JB, McQuown SC, Leslie FM. The dynamic effects of nicotine on the developing brain. Pharmacology & Therapeutics 2009, 122: 125-139. PMID: 19268688, PMCID: PMC2746456, DOI: 10.1016/j.pharmthera.2009.02.003.Peer-Reviewed Original ResearchConceptsNicotine exposureDevelopmental influencesAdolescent periodBrain maturationExogenous nicotineHuman brainUnique effectsMaturational periodNeural structuresLimbic systemClinical literatureNicotine replacement therapyEnvironmental stimuliEarly postnatal periodPreclinical animal modelsDevelopmental windowNicotinic acetylcholine receptorsPrenatal periodReplacement therapyEarly postnatalPostnatal periodTobacco smokeAnimal modelsAcetylcholine receptorsNicotine