2022
A phylogenetic approach to study the evolution of somatic mutational processes in cancer
Miura S, Vu T, Choi J, Townsend JP, Karim S, Kumar S. A phylogenetic approach to study the evolution of somatic mutational processes in cancer. Communications Biology 2022, 5: 617. PMID: 35732905, PMCID: PMC9217972, DOI: 10.1038/s42003-022-03560-0.Peer-Reviewed Original ResearchConceptsMutational processesPattern of conservationFalse-positive discovery rateCollection of mutationsSomatic mutational processesPhylogenetic approachGenomic variationSomatic variationCell lineagesMutational signaturesTumor evolutionMutation signaturesPhylogenyCancer cellsDiscovery rateMutationsComputer-simulated datasetsRelative activityLineagesComputational methodsSignaturesConservationDivergenceEvolutionJoint analysis
2014
The peopling of the African continent and the diaspora into the new world
Campbell MC, Hirbo JB, Townsend JP, Tishkoff SA. The peopling of the African continent and the diaspora into the new world. Current Opinion In Genetics & Development 2014, 29: 120-132. PMID: 25461616, PMCID: PMC4308437, DOI: 10.1016/j.gde.2014.09.003.Peer-Reviewed Original ResearchConceptsAfrican diasporaModern humansHuman historyHuman migrationNew WorldDemographic historyAfrican descentAfrican continentDemographic eventsHistoryDiasporaEvolutionary questionsAfrican populationsPhenotypic variationContinentGenomic dataAfricaGeographic originDisease susceptibilityPeoplingBirthplaceRecent findingsCorresponding developmentWorldComputational methods