Featured Publications
Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma
Fisk JN, Mahal AR, Dornburg A, Gaffney SG, Aneja S, Contessa JN, Rimm D, Yu JB, Townsend JP. Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma. Cancer Letters 2021, 526: 346-351. PMID: 34780851, PMCID: PMC8702484, DOI: 10.1016/j.canlet.2021.11.011.Peer-Reviewed Original ResearchConceptsMutational processesSingle ancestral lineageAncestral lineageProgression of cancerMetastatic lineagesPhylogenetic analysisGenetic resistanceEvolutionary processesExogenous mutational processesCancer evolutionConsolidative therapyMutational signature analysisEGFR-positive non-small cell lung cancerNon-small cell lung cancerKey eventsLineagesCell populationsTherapeutic resistanceLocal consolidative therapyClinical time courseCell lung cancerDisease etiologyTherapeutic decision makingCisplatin therapyLung cancer
2007
Profiling Phylogenetic Informativeness
Townsend JP. Profiling Phylogenetic Informativeness. Systematic Biology 2007, 56: 222-231. PMID: 17464879, DOI: 10.1080/10635150701311362.Peer-Reviewed Original ResearchConceptsPhylogenetic informativenessRapid radiationPhylogenetic studiesCharacter samplingBroad phylogenetic studyRapid adaptive radiationGenome-scale dataAddition of charactersAdaptive radiationPhylogenetic signalSoft polytomiesPhylogenetic profilesPhylogenetic hypothesisAncestral lineagePhylogenetic experimentsEarly metazoansPhylogenetic charactersSequence dataMuroid rodentsHistorical radiationPolytomyBase pairsGenesC-MycGenes BRCA1