2022
Breaking the Glass Ceiling Low eGFR in the Use of MRA Therapy ∗
Damman K, Testani J. Breaking the Glass Ceiling Low eGFR in the Use of MRA Therapy ∗. JACC Heart Failure 2022, 10: 871-873. PMID: 36328656, DOI: 10.1016/j.jchf.2022.08.017.Commentaries, Editorials and LettersDiabetes Mellitus, Type 2EplerenoneHeart FailureHumansMineralocorticoid Receptor AntagonistsRenal Insufficiency, Chronic
2021
Multinephron Segment Diuretic Therapy to Overcome Diuretic Resistance in Acute Heart Failure: A Single-Center Experience
Cox ZL, Sarrell BA, Cella MK, Tucker B, Arroyo JP, Umanath K, Tidwell W, Guide A, Testani JM, Lewis JB, Dwyer JP. Multinephron Segment Diuretic Therapy to Overcome Diuretic Resistance in Acute Heart Failure: A Single-Center Experience. Journal Of Cardiac Failure 2021, 28: 21-31. PMID: 34403831, DOI: 10.1016/j.cardfail.2021.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseDiureticsHeart FailureHumansMineralocorticoid Receptor AntagonistsProspective StudiesRetrospective StudiesSodium Potassium Chloride Symporter InhibitorsConceptsAcute heart failureDiuretic resistanceDiuretic therapyHeart failureUrine outputSerum chemistryRenal replacement therapySingle medical centerSingle-center experienceAHF cohortDiuretic classesHospital mortalityTotal cohortKidney functionSerum sodiumCarbonic anhydrase inhibitorsProspective studyReplacement therapyCase-level evidenceRetrospective analysisMedical CenterDay 7Own controlTherapyPatients
2018
Perturbations in serum chloride homeostasis in heart failure with preserved ejection fraction: insights from TOPCAT
Grodin JL, Testani JM, Pandey A, Sambandam K, Drazner MH, Fang JC, Tang WHW. Perturbations in serum chloride homeostasis in heart failure with preserved ejection fraction: insights from TOPCAT. European Journal Of Heart Failure 2018, 20: 1436-1443. PMID: 29893446, DOI: 10.1002/ejhf.1229.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersCause of DeathChloridesFemaleHeart FailureHeart VentriclesHomeostasisHumansMaleMineralocorticoid Receptor AntagonistsPrognosisSpironolactoneStroke VolumeTreatment OutcomeUnited StatesConceptsSerum chloride levelsLoop diuretic useHeart failureSerum chlorideCause deathDiuretic useEjection fractionMultivariable Cox proportional hazards modelsCardiac Function Heart FailureCox proportional hazards modelAldosterone Antagonist TrialHeart failure hospitalizationPrimary composite endpointLower serum chlorideProportional hazards modelSerum chloride concentrationChloride levelsSpironolactone useCardiovascular deathFailure hospitalizationMultivariable adjustmentComposite endpointLoop diureticsClinical outcomesHazards model