2023
SGLT2 inhibitors and diuretics in heart failure: clicking reset on the renal volume setpoint?
Borlaug B, Testani J. SGLT2 inhibitors and diuretics in heart failure: clicking reset on the renal volume setpoint? European Heart Journal 2023, 44: 2944-2946. PMID: 37220086, DOI: 10.1093/eurheartj/ehad345.Commentaries, Editorials and Letters
2018
Perturbations in serum chloride homeostasis in heart failure with preserved ejection fraction: insights from TOPCAT
Grodin JL, Testani JM, Pandey A, Sambandam K, Drazner MH, Fang JC, Tang WHW. Perturbations in serum chloride homeostasis in heart failure with preserved ejection fraction: insights from TOPCAT. European Journal Of Heart Failure 2018, 20: 1436-1443. PMID: 29893446, DOI: 10.1002/ejhf.1229.Peer-Reviewed Original ResearchConceptsSerum chloride levelsLoop diuretic useHeart failureSerum chlorideCause deathDiuretic useEjection fractionMultivariable Cox proportional hazards modelsCardiac Function Heart FailureCox proportional hazards modelAldosterone Antagonist TrialHeart failure hospitalizationPrimary composite endpointLower serum chlorideProportional hazards modelSerum chloride concentrationChloride levelsSpironolactone useCardiovascular deathFailure hospitalizationMultivariable adjustmentComposite endpointLoop diureticsClinical outcomesHazards model
2011
Impact of changes in blood pressure during the treatment of acute decompensated heart failure on renal and clinical outcomes†
Testani JM, Coca SG, McCauley BD, Shannon RP, Kimmel SE. Impact of changes in blood pressure during the treatment of acute decompensated heart failure on renal and clinical outcomes†. European Journal Of Heart Failure 2011, 13: 877-884. PMID: 21693504, PMCID: PMC3143830, DOI: 10.1093/eurjhf/hfr070.Peer-Reviewed Original ResearchConceptsDecompensated heart failureBlood pressure reductionSystolic blood pressureHeart failureBlood pressurePulmonary Artery Catheterization Effectiveness trialAcute decompensated heart failureSignificant blood pressure reductionSystolic blood pressure reductionPressure reductionThiazide diuretic useCongestive heart failureDifferent prognostic implicationsRegional vascular bedsFinal common pathwayGreater weight reductionOral vasodilatorsDiuretic useRenal functionWorsened survivalAdverse prognosisPerfusion pressurePrognostic implicationsPrognostic significanceEffectiveness trial