Altered Hemodynamics and End-Organ Damage in Heart Failure
Verbrugge FH, Guazzi M, Testani JM, Borlaug BA. Altered Hemodynamics and End-Organ Damage in Heart Failure. Circulation 2020, 142: 998-1012. PMID: 32897746, PMCID: PMC7482031, DOI: 10.1161/circulationaha.119.045409.Peer-Reviewed Original ResearchConceptsHeart failureHemodynamic derangementsHemodynamic perturbationsElevated cardiac filling pressuresReduced cardiac outputCardiac filling pressuresEnd-organ damagePulmonary vascular diseaseHeart failure phenotypeMultiple organ systemsCapillary stress failureDevelopment of abnormalitiesCardiogenic shockHemodynamic abnormalitiesRenal functionEjection fractionClinical outcomesPulmonary congestionVenous capacityCardiac outputPericardial constraintVascular diseaseChronic diseasesFilling pressureVentilatory control