2024
Dapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial
Tada A, Burkhoff D, Naser J, Harada T, Pourmussa B, Reddy Y, Jensen M, Carter R, Demmer R, Testani J, Chirinos J, Borlaug B. Dapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial. Circulation 2024, 150: 997-1009. PMID: 39101201, PMCID: PMC11433515, DOI: 10.1161/circulationaha.124.068788.Peer-Reviewed Original ResearchConceptsSystemic arterial complianceEffects of dapagliflozinStressed blood volumeVenous capacitanceBlood volumePeak exerciseArterial complianceHemodynamic congestionHeart failureEstimating stressed blood volumeImproved systemic arterial complianceInvasive hemodynamic exercise testingSodium-glucose cotransporter-2 inhibitorsSystolic BPPulmonary capillary wedge pressureHemodynamic exercise testingCapillary wedge pressureCotransporter-2 inhibitorsSystemic vascular resistanceImproving clinical outcomesTotal blood volumeRadial artery pressureSimultaneous echocardiographyEjection fractionFluid-filled catheter
2018
Hemodynamic factors associated with serum chloride in ambulatory patients with advanced heart failure
Grodin JL, Mullens W, Dupont M, Taylor DO, McKie PM, Starling RC, Testani JM, Tang WHW. Hemodynamic factors associated with serum chloride in ambulatory patients with advanced heart failure. International Journal Of Cardiology 2018, 252: 112-116. PMID: 29249420, DOI: 10.1016/j.ijcard.2017.11.024.Peer-Reviewed Original ResearchConceptsPulmonary capillary wedge pressureAdvanced chronic heart failureFick cardiac indexPulmonary artery systolic pressureRight atrial pressureVentricular assist device placementHeart transplantHeart rateHeart failureSerum chlorideHigher cardiac filling pressuresPoor long-term outcomesSerum Cl levelsCapillary wedge pressureCardiac filling pressuresChronic heart failureAdvanced heart failureInvasive hemodynamic assessmentHeart failure patientsRisk of deathLong-term outcomesLower serum chlorideConventional clinical parametersBackward regression modelAssociation of hemodynamics
2010
Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival
Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP. Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival. Circulation 2010, 122: 265-272. PMID: 20606118, PMCID: PMC3025294, DOI: 10.1161/circulationaha.109.933275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood ProteinsBlood VolumeExtracellular FluidFemaleGlomerular Filtration RateHeart FailureHematocritHumansKidneyMaleMiddle AgedPulmonary Wedge PressureSerum AlbuminSodium Chloride Symporter InhibitorsSodium Potassium Chloride Symporter InhibitorsTreatment OutcomeVentricular PressureConceptsDecompensated heart failureRenal functionAggressive decongestionHeart failurePulmonary Artery Catheterization Effectiveness trialPulmonary capillary wedge pressureAggressive fluid removalCapillary wedge pressureIntravascular volume depletionRight atrial pressureCongestive heart failureEvidence of hemoconcentrationAggressive diuresisIntravascular substancesWedge pressureAtrial pressureBaseline characteristicsLoop diureticsTop tertileVolume depletionEffectiveness trialExtravascular fluidFluid removalHemoconcentrationHigh doses