2017
Novel Biomarkers for the Risk Stratification of Heart Failure with Preserved Ejection Fraction
Cypen J, Ahmad T, Testani JM, DeVore AD. Novel Biomarkers for the Risk Stratification of Heart Failure with Preserved Ejection Fraction. Current Heart Failure Reports 2017, 14: 434-443. PMID: 28803400, DOI: 10.1007/s11897-017-0358-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHeart failureEjection fractionHF biomarkersRisk stratificationReduced ejection fractionTreatment of HFpEFBrain natriuretic peptideValuable prognostic markerKey pathophysiologic componentUse of biomarkersSignificant therapeutic targetSystemic inflammationPathophysiologic componentsNatriuretic peptidePrognostic valueMyocardial fibrosisPrognostic markerNovel biomarkersCurrent evidenceTherapeutic targetHFpEFReviewThe useSummaryFurther investigationBiomarkersInflammation
2015
The Current and Potential Clinical Relevance of Heart Failure Biomarkers
Gandhi PU, Testani JM, Ahmad T. The Current and Potential Clinical Relevance of Heart Failure Biomarkers. Current Heart Failure Reports 2015, 12: 318-327. PMID: 26280466, DOI: 10.1007/s11897-015-0268-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHeart failureHeart failure biomarkersHigh-sensitivity cardiac troponinManagement of patientsDefinitive clinical trialsCare of patientsPotential clinical relevanceNon-specific natureSoluble ST2Risk stratificationNatriuretic peptideDevastating conditionClinical trialsCardiac troponinClinical relevancePhysiologic aspectsGalectin-3BiomarkersCandidate markersPatientsMulti-marker approachDiagnosisCareFailurePathophysiology
2014
Novel Renal Biomarkers to Assess Cardiorenal Syndrome
Brisco MA, Testani JM. Novel Renal Biomarkers to Assess Cardiorenal Syndrome. Current Heart Failure Reports 2014, 11: 485-499. PMID: 25239434, PMCID: PMC4224613, DOI: 10.1007/s11897-014-0226-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRenal dysfunctionCardiorenal syndromeHeart failureRenal biomarkersNormal glomerular filtration rateIrreversible nephron lossSignificant renal impairmentHypertensive kidney diseaseGlomerular filtration rateNovel renal biomarkersCardiorenal interactionsRenal impairmentNephron lossDecongestive therapyAdverse outcomesKidney diseaseFiltration rateHigh prevalenceRenal performanceSyndromeBiomarkersFailurePrognosisDysfunctionTherapy