2008
A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells
Li H, Wang J, Mor G, Sklar J. A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells. Science 2008, 321: 1357-1361. PMID: 18772439, DOI: 10.1126/science.1156725.Peer-Reviewed Original ResearchMeSH KeywordsCell HypoxiaCell LineCell Line, TumorChromosome AberrationsChromosomes, Human, Pair 17Chromosomes, Human, Pair 7Co-Repressor ProteinsDeferoxamineDNA-Binding ProteinsEndometrial NeoplasmsEndometriumExonsFemaleGene FusionHumansMenstrual CycleMutant Chimeric ProteinsNeoplasm ProteinsProgesteroneProtein BiosynthesisRNA PrecursorsRNA, MessengerStromal CellsTrans-SplicingTranscription FactorsTranslocation, GeneticConceptsGene fusionsChimeric RNAsPrecursor messenger RNAChimeric gene productsResultant chimeric transcriptsTrans splicingNormal human cellsAnti-apoptotic activityChromosome 7p15Gene productsChromosomal rearrangementsChromosome 17q11JAZF1 geneHuman cellsTumor-specific productsRNANormal endometrial stromal cellsChimeric transcriptsMessenger RNAExonsProteinHuman tumorsStromal cellsEndometrial stromal cellsCells
2007
Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival
Li H, Ma X, Wang J, Koontz J, Nucci M, Sklar J. Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20001-20006. PMID: 18077430, PMCID: PMC2148412, DOI: 10.1073/pnas.0709986104.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosisCarrier ProteinsCell LineCell Line, TumorCell ProliferationCell SurvivalCo-Repressor ProteinsDNA-Binding ProteinsFemaleGene FusionGene RearrangementHumansNeoplasm ProteinsNuclear ProteinsPolycomb Repressive Complex 2Sarcoma, Endometrial StromalTranscription FactorsTranslocation, GeneticConceptsAllelic exclusionHistone 3 lysine 27 trimethylationPolycomb group genesChromosomal translocationsLikely functional importanceLysine 27 trimethylationPolycomb protein EZH2Protein EZH2Group genesUnrearranged copyGenetic pathwaysMalignant formNormal proliferation rateJAZF1 geneFunctional importanceGene fusionsCell survivalHEK293 cellsGenesCultured cellsCell growthEndometrial stromal tumorsCellular proliferationCell proliferationSUZ12