Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma.
Cleary ML, Chao J, Warnke R, Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 593-597. PMID: 6607475, PMCID: PMC344725, DOI: 10.1073/pnas.81.2.593.Peer-Reviewed Original ResearchConceptsClonal immunoglobulin gene rearrangementsB-cell lymphomaImmunoglobulin gene rearrangementsGene rearrangementsReactive lymphoid processesB-cell originNon-neoplastic specimensSubset of lymphomasTotal cell populationLymph nodesLymphoproliferative disordersNeoplastic lymphocytesCytoplasmic immunoglobulinConventional diagnostic methodsPresence of rearrangementsBiopsy tissueCellular immunoglobulinsDiagnostic criteriaLymphoid processesBiopsy samplesLymphomaAntigenic markersSouthern blot hybridization techniqueBlot hybridization technique