INPP5E Preserves Genomic Stability through Regulation of Mitosis
Potchanant E, Cerabona D, Sater Z, He Y, Sun Z, Gehlhausen J, Nalepa G. INPP5E Preserves Genomic Stability through Regulation of Mitosis. Molecular And Cellular Biology 2017, 37: e00500-16. PMID: 28031327, PMCID: PMC5335510, DOI: 10.1128/mcb.00500-16.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCell NucleusFibroblastsGene Knockdown TechniquesGenomic InstabilityHeLa CellsHomeostasisHumansInterphaseM Phase Cell Cycle CheckpointsMiceMitosisModels, BiologicalPhosphatidylinositol 4,5-DiphosphatePhosphoric Monoester HydrolasesProtein TransportSubcellular FractionsSubstrate SpecificityConceptsCell cycle regulatory roleMaintenance of chromosome integrityPreserving genome stabilityInositol polyphosphate-5-phosphataseRegulating cell divisionRegulation of mitosisPrevention of aneuploidySpindle assembly checkpointEarly mitosisMORM syndromesMitotic exitGenome stabilityPhosphoinositide phosphataseMitotic entryChromosomal integrationCellular homeostasisINPP5ECell divisionPrimary ciliaCell cycleAssembly checkpointCellular metabolismSpindle functionGenetic knockoutRegulatory role