2011
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa
Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nature Communications 2011, 2: 153. PMID: 21224844, PMCID: PMC3999383, DOI: 10.1038/ncomms1153.Peer-Reviewed Original ResearchHyperactivation of motilityCatSper channel complexMale fertilityChannel α-subunitsNovel subunitNovel genesHyperactivated motilitySperm proteinsGene productsChannel assemblyAuxiliary subunitsΑ-subunitSuccessful fertilizationCalcium signalingSelective poresSpermatozoa lackChannel functionSubunitsSperm Ca2Channel complexCation channelsGenesChannel formationProteinAcrosome reaction
2008
Ion channels that control fertility in mammalian spermatozoa
Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. The International Journal Of Developmental Biology 2008, 52: 607-613. PMID: 18649274, PMCID: PMC4297656, DOI: 10.1387/ijdb.072554bn.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMammalian spermatozoaGenetic deletion strategiesMammalian spermPhysiological roleIon channelsDeletion strategyIon channel currentsHyperactivated motilityChannel currentsUnambiguous identificationIntracellular alkalinizationWhole-cell voltage clampSpermatozoaGenesTechnical advancesVoltage clampSpermMotilityExpressionFertilizationCa2FertilityIdentification