A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [11C](+)PHNO
Matuskey D, Gaiser EC, Gallezot JD, Angarita GA, Pittman B, Nabulsi N, Ropchan J, MaCleod P, Cosgrove KP, Ding YS, Potenza MN, Carson RE, Malison RT. A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [11C](+)PHNO. Drug And Alcohol Dependence 2015, 154: 167-173. PMID: 26164205, PMCID: PMC4536182, DOI: 10.1016/j.drugalcdep.2015.06.039.Peer-Reviewed Original ResearchConceptsPositron emission tomographyNon-human primatesInverse associationCD groupReceptor availabilityHealthy non-human primatesSubstantia nigra/ventral tegmental areaBarratt Simplified MeasureDopamine D2/3 receptor availabilityBody mass indexVentral tegmental areaCocaine-dependent humansChronic cocaine administrationDependent humansD2/3 receptor availabilitySN/VTAMass indexCD subjectsRegional brainExtrastriatal regionsTegmental areaCocaine administrationAntagonist radioligandAgonist radioligandCD individualsReference Region Modeling Approaches for Amphetamine Challenge Studies with [11C]FLB 457 and PET
Sandiego CM, Gallezot JD, Lim K, Ropchan J, Lin SF, Gao H, Morris ED, Cosgrove KP. Reference Region Modeling Approaches for Amphetamine Challenge Studies with [11C]FLB 457 and PET. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 623-629. PMID: 25564239, PMCID: PMC4420880, DOI: 10.1038/jcbfm.2014.237.Peer-Reviewed Original ResearchConceptsPositron emission tomographyExtrastriatal regionsBrain regionsAmphetamine-induced dopamine releaseHealthy tobacco smokersExtrastriatal brain regionsSynaptic dopamine levelsAmphetamine-induced changesSimplified reference tissue modelReference tissue modelTobacco smokersDopaminergic dysfunctionAmphetamine administrationDopamine levelsDopamine releasePsychiatric disordersChallenge studiesDistribution volumeEmission tomographyD3 bindingReference region modelCerebellumReference regionBaselineSignificant changes