2024
Open Burn Pit Exposure in Headache Disorder and Migraine
Sico J, Anthony S, Phadke M, Wang K, Skanderson M, Ney J, Seng E, Shapiro R, Sandbrink F, Scholten J, Graham G, Martini S, Fenton B. Open Burn Pit Exposure in Headache Disorder and Migraine. JAMA Network Open 2024, 7: e2431522. PMID: 39230902, PMCID: PMC11375476, DOI: 10.1001/jamanetworkopen.2024.31522.Peer-Reviewed Original ResearchConceptsBurn pit exposureVeterans Health Administration electronic health recordPit exposureHeadache disordersAdministration electronic health recordAnalytic sampleVeterans Health Administration facilitiesBurn pitsCohort studyVeterans Health AdministrationElectronic health recordsDose-dependent associationUS DepartmentHealth recordsRegistry participantsMilitary exposuresRetrospective cohort studyHealth AdministrationMain OutcomesHealth conditionsAdministration facilitiesRegistry questionnaireHighest quartilesIncident outcomesVeterans
2021
Depression as a Risk Factor for Incident Ischemic Stroke Among HIV‐Positive Veterans in the Veterans Aging Cohort Study
Sico JJ, Kundu S, So‐Armah K, Gupta SK, Chang C, Butt AA, Gibert CL, Marconi VC, Crystal S, Tindle HA, Freiberg MS, Stewart JC. Depression as a Risk Factor for Incident Ischemic Stroke Among HIV‐Positive Veterans in the Veterans Aging Cohort Study. Journal Of The American Heart Association 2021, 10: e017637. PMID: 34169726, PMCID: PMC8403311, DOI: 10.1161/jaha.119.017637.Peer-Reviewed Original ResearchConceptsHIV-positive peopleBaseline antidepressant useCerebrovascular risk factorsRisk of strokeRisk factorsAlcohol use disorderStroke riskAntidepressant useUse disordersCocaine useSociodemographic characteristicsTraditional cerebrovascular risk factorsVeterans Aging Cohort StudyCox proportional hazards modelBackground HIV infectionHIV-specific factorsIndividual antiretroviral agentsAntiretroviral therapy useBaseline cardiovascular diseaseIndependent risk factorAging Cohort StudyIschemic stroke riskHIV-positive veteransProportional hazards modelUninfected veteransDemoralization predicts suicidality in patients with cluster headache
Koo BB, Bayoumi A, Albanna A, Abusuliman M, Burrone L, Sico JJ, Schindler EAD. Demoralization predicts suicidality in patients with cluster headache. The Journal Of Headache And Pain 2021, 22: 28. PMID: 33879041, PMCID: PMC8056539, DOI: 10.1186/s10194-021-01241-7.Peer-Reviewed Original ResearchConceptsLifetime suicidal ideationSuicidal ideationHigh suicide riskSuicide riskControl participantsDiagnostic criteriaBrief Lifetime Depression ScaleObservational case-control studyLifetime depression historyColumbia-Suicide Severity Rating ScaleCluster headache patientsCase-control studyEdition diagnostic criteriaActive suicidal ideationStepwise logistic regressionSeverity Rating ScaleCH sufferersLittle empiric dataOrbital painCH diagnosisCluster headacheHeadache patientsHeadache disordersDepression ScaleSuicidal Behaviors Questionnaire
2019
Polysomnography Utilization in Veterans Presenting Acutely with Ischemic Stroke or Transient Ischemic Attack
Koo BB, Sico JJ, Myers LJ, Perkins AJ, Levine D, Miech EJ, Damush TM, Rattray N, Homoya B, Ferguson J, Myers J, Zhang Y, Bravata DM. Polysomnography Utilization in Veterans Presenting Acutely with Ischemic Stroke or Transient Ischemic Attack. Cerebrovascular Diseases 2019, 48: 179-183. PMID: 31722335, DOI: 10.1159/000504406.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaComorbidityFemaleHealth Services AccessibilityHealth StatusHumansIschemic Attack, TransientMaleMiddle AgedPolysomnographyPractice Guidelines as TopicPractice Patterns, Physicians'Predictive Value of TestsPrognosisRisk FactorsSleep Apnea, ObstructiveStrokeTime FactorsUnited StatesUnited States Department of Veterans AffairsVeterans HealthConceptsTransient ischemic attackAcute ischemic strokeObstructive sleep apneaVeterans Administration Medical CenterTreatment of OSAIschemic strokeIschemic attackClinical dataExact testVA Corporate Data WarehouseCerebrovascular risk factorsMixed-effects logistic regressionFisher's exact testCorporate Data WarehouseEffects logistic regressionTwo-sample t-testAcute strokeClinical characteristicsHospital dischargeHeart failureSleep apneaFunctional outcomeRisk factorsUS veteransRecent guidelinesPosttraumatic Stress Disorder and Risk for Stroke in Young and Middle-Aged Adults
Rosman L, Sico JJ, Lampert R, Gaffey AE, Ramsey CM, Dziura J, Chui PW, Cavanagh CE, Brandt C, Haskell S, Burg MM. Posttraumatic Stress Disorder and Risk for Stroke in Young and Middle-Aged Adults. Stroke 2019, 50: 2996-3003. PMID: 31619151, DOI: 10.1161/strokeaha.119.026854.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIncident transient ischemic attackPosttraumatic stress disorderEffects of PTSDIschemic strokeIncident strokeHealthcare utilizationIncidence of TIAStress disorderYoung adultsMiddle-aged veteransStroke risk factorsMultivariate Cox modelIschemic stroke riskAge-specific prevention strategiesVeterans Health AdministrationMiddle-aged adultsIschemic attackStroke riskPsychological factorsUnadjusted analysesRisk factorsEffect modificationCox modelPsychiatric disordersMicrovascular Disease, Peripheral Artery Disease and Amputation
Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, Bedimo RJ, Butt AA, Marconi VC, Sico JJ, Tindle HA, Bonaca MP, Aday AW, Freiberg MS. Microvascular Disease, Peripheral Artery Disease and Amputation. Circulation 2019, 140: 449-458. PMID: 31280589, PMCID: PMC6682431, DOI: 10.1161/circulationaha.119.040672.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmputation, SurgicalComorbidityDiabetes ComplicationsDisease SusceptibilityExtremitiesFemaleFollow-Up StudiesHumansIschemiaKidney DiseasesMaleMicrocirculationMiddle AgedPeripheral Arterial DiseasePeripheral Nervous System DiseasesPrevalenceProcedures and Techniques UtilizationProportional Hazards ModelsProspective StudiesRetinal DiseasesRisk FactorsVeteransConceptsPeripheral artery diseaseRisk of amputationMicrovascular diseaseArtery diseaseRisk factorsVeterans Aging Cohort StudyCox proportional hazards regressionAdverse limb eventsPrevalent microvascular diseaseCardiovascular risk factorsTraditional risk factorsAging Cohort StudyMultivariable-adjusted analysesProportional hazards regressionLower limb amputationIncident amputationsPrior amputationCohort studyAmputation eventsHazards regressionLarge cohortElevated riskLimb amputationLimb eventsAmputationProcesses of Care Associated With Risk of Mortality and Recurrent Stroke Among Patients With Transient Ischemic Attack and Nonsevere Ischemic Stroke
Bravata DM, Myers LJ, Reeves M, Cheng EM, Baye F, Ofner S, Miech EJ, Damush T, Sico JJ, Zillich A, Phipps M, Williams LS, Chaturvedi S, Johanning J, Yu Z, Perkins AJ, Zhang Y, Arling G. Processes of Care Associated With Risk of Mortality and Recurrent Stroke Among Patients With Transient Ischemic Attack and Nonsevere Ischemic Stroke. JAMA Network Open 2019, 2: e196716. PMID: 31268543, PMCID: PMC6613337, DOI: 10.1001/jamanetworkopen.2019.6716.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaEligibility DeterminationFemaleHumansIschemic Attack, TransientLong Term Adverse EffectsMaleMiddle AgedMortalityOutcome and Process Assessment, Health CarePatient Care ManagementPrognosisRecurrenceRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeUnited StatesVeterans Health ServicesConceptsTransient ischemic attackRecurrent ischemic strokeIschemic strokeRisk of deathRecurrent strokeProcess of careLower oddsMedication intensificationIschemic attackAtrial fibrillationVeterans Affairs emergency departmentAntihypertensive medication classesMortality 1 yearManagement of patientsMultivariable logistic regressionRisk of mortalityMultiple comparisonsCarotid artery imagingCause mortalityLipid managementMedication classesStatin medicationStatin therapyCohort studyStroke risk
2018
Uncertainty as a Key Influence in the Decision To Admit Patients with Transient Ischemic Attack
Homoya BJ, Damush TM, Sico JJ, Miech EJ, Arling GW, Myers LJ, Ferguson JB, Phipps MS, Cheng EM, Bravata DM. Uncertainty as a Key Influence in the Decision To Admit Patients with Transient Ischemic Attack. Journal Of General Internal Medicine 2018, 34: 1715-1723. PMID: 30484102, PMCID: PMC6712185, DOI: 10.1007/s11606-018-4735-9.Peer-Reviewed Original ResearchConceptsTransient ischemic attackVA Medical CenterTIA patientsChart review dataAdmission ratesTIA admissionsTIA careABCD2 scoreIschemic attackChart reviewAdministrative dataSubsequent vascular eventsSecondary prevention strategiesSubset of patientsQuality improvement interventionsHigher admission ratesQuality of careKey ResultsProvidersTimely workupVascular eventsEmergency departmentInpatient settingMedical CenterHigh riskPatientsAssociation between admission haematocrit and mortality among men with acute ischaemic stroke
Sico JJ, Myers LJ, Fenton BJ, Concato J, Williams LS, Bravata DM. Association between admission haematocrit and mortality among men with acute ischaemic stroke. Stroke And Vascular Neurology 2018, 3: 160. PMID: 30294472, PMCID: PMC6169611, DOI: 10.1136/svn-2018-000149.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeIschemic strokeAdmission haematocritAdjusted ORsChronic Health Evaluation IIIVeterans Health Administration facilitiesFirst year post strokeHours of admissionRisk of deathHaematocrit valuesMultivariate logistic regressionYear post strokeAcute PhysiologyHospital mortalityMedical comorbiditiesPoststroke mortalityStroke severityBlood transfusionSevere anemiaPost strokeHeart diseaseMedical recordsPatient outcomesCardiovascular conditionsPatients
2017
Comparison of Risk Factor Control in the Year After Discharge for Ischemic Stroke Versus Acute Myocardial Infarction
Bravata DM, Daggy J, Brosch J, Sico JJ, Baye F, Myers LJ, Roumie CL, Cheng E, Coffing J, Arling G. Comparison of Risk Factor Control in the Year After Discharge for Ischemic Stroke Versus Acute Myocardial Infarction. Stroke 2017, 49: 296-303. PMID: 29284738, DOI: 10.1161/strokeaha.117.017142.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRisk factor controlIncident ischemic strokeBlood pressure controlIschemic stroke patientsIschemic strokeStroke patientsGlycemic controlAMI patientsMyocardial infarctionPressure controlIncident acute myocardial infarctionChronic obstructive pulmonary diseaseVascular risk factor controlFacility-level covariatesTransient ischemic attackAcute ischemic strokeCongestive heart failureObstructive pulmonary diseaseVeterans Health AdministrationFactor controlFacility covariatesIschemic attackHypertension controlStroke preventionDevelopment, Validation, and Assessment of an Ischemic Stroke or Transient Ischemic Attack-Specific Prediction Tool for Obstructive Sleep Apnea
Sico JJ, Yaggi HK, Ofner S, Concato J, Austin C, Ferguson J, Qin L, Tobias L, Taylor S, Fragoso C, McLain V, Williams LS, Bravata DM. Development, Validation, and Assessment of an Ischemic Stroke or Transient Ischemic Attack-Specific Prediction Tool for Obstructive Sleep Apnea. Journal Of Stroke And Cerebrovascular Diseases 2017, 26: 1745-1754. PMID: 28416405, PMCID: PMC6006998, DOI: 10.1016/j.jstrokecerebrovasdis.2017.03.042.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overArea Under CurveBrain IschemiaDecision Support TechniquesFemaleHumansIschemic Attack, TransientMaleMiddle AgedPolysomnographyPredictive Value of TestsPrevalencePrognosisReproducibility of ResultsRisk AssessmentRisk FactorsROC CurveSleepSleep Apnea, ObstructiveStrokeSurveys and QuestionnairesTime FactorsUnited StatesConceptsObstructive sleep apneaTransient ischemic attackHigh negative predictive valueEpworth Sleepiness ScaleNegative predictive valueIschemic strokeSleep apneaPresence of OSASleep InventoryPredictive valueSleep Apnea Clinical ScoreValidation study populationHigh blood pressureBody mass indexIschemic attackObserved apneaBerlin questionnaireStroke severityBlood pressureOvernight polysomnographyMass indexRandomized trialsClinical scoresSleep QuestionnaireMedical history
2016
Taking care of volunteers in a stroke trial: a new assisted-management strategy
Stuart AC, Sico JJ, Viscoli CM, Tayal AH, Inzucchi SE, Ford GA, Furie KL, Cote R, Spence JD, Tanne D, Kernan WN. Taking care of volunteers in a stroke trial: a new assisted-management strategy. Stroke And Vascular Neurology 2016, 1: 108. PMID: 28959471, PMCID: PMC5435205, DOI: 10.1136/svn-2016-000029.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticholesteremic AgentsAntihypertensive AgentsBiomarkersBlood CoagulationBlood PressureCholesterol, LDLDouble-Blind MethodEuropeFemaleFibrinolytic AgentsHumansHypoglycemic AgentsInsulin ResistanceIschemic Attack, TransientIschemic StrokeIsraelMaleMiddle AgedNorth AmericaPioglitazoneRecurrenceRisk AssessmentRisk FactorsRisk Reduction BehaviorSecondary PreventionTime FactorsTreatment OutcomeConceptsPersonal healthcare providerBlood pressureStroke trialsPreventive careTrial participantsLow-density lipoprotein cholesterolPrevention goalsInsulin Resistance InterventionTransient ischemic attackPrevention of strokeSecondary prevention goalsEvidence-based careProportion of participantsIschemic attackAntithrombotic therapyIschemic strokeLipoprotein cholesterolSecondary preventionAntithrombotic useStroke therapyInsulin sensitisersMyocardial infarctionAnnual visitsHealthcare providersResistance InterventionObservational Study of Obstructive Sleep Apnea in Wake-Up Stroke: The SLEEP TIGHT Study
Koo BB, Bravata DM, Tobias LA, Mackey JS, Miech EJ, Matthias MS, Stahl SM, Sico JJ, Fragoso C, Williams LS, Lampert R, Qin L, Yaggi HK. Observational Study of Obstructive Sleep Apnea in Wake-Up Stroke: The SLEEP TIGHT Study. Cerebrovascular Diseases 2016, 41: 233-241. PMID: 26811929, DOI: 10.1159/000440736.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersBlood PressureBlood Pressure Monitoring, AmbulatoryBrain IschemiaChi-Square DistributionCholesterol, LDLConnecticutCross-Sectional StudiesFemaleHumansIndianaIschemic Attack, TransientLogistic ModelsMaleMiddle AgedOdds RatioOxygenPolysomnographyPrevalenceRandomized Controlled Trials as TopicRisk FactorsSeverity of Illness IndexSex FactorsSleepSleep Apnea, ObstructiveStrokeSympathetic Nervous SystemWakefulnessConceptsObstructive sleep apneaDiastolic blood pressureSevere obstructive sleep apneaLow-density lipoproteinBlood pressureSleep apneaSerum catecholaminesAmbulatory blood pressure monitoringBaseline diastolic blood pressureMean body mass indexB-type natriuretic peptideHigher diastolic blood pressureMore oxygen desaturationTransient ischemic attackIschemic stroke patientsAmbulatory blood pressureHistory of strokeBody mass indexC-reactive proteinBlood pressure monitoringOxygen desaturation eventsGender-stratified analysesCross-sectional analysisIschemic attackOSA frequency
2015
Infarct location and sleep apnea: evaluating the potential association in acute ischemic stroke
Stahl SM, Yaggi HK, Taylor S, Qin L, Ivan CS, Austin C, Ferguson J, Radulescu R, Tobias L, Sico J, Fragoso C, Williams LS, Lampert R, Miech EJ, Matthias MS, Kapoor J, Bravata DM. Infarct location and sleep apnea: evaluating the potential association in acute ischemic stroke. Sleep Medicine 2015, 16: 1198-1203. PMID: 26429745, PMCID: PMC4592521, DOI: 10.1016/j.sleep.2015.07.003.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaApnea-hypopnea indexAcute ischemic strokeIschemic stroke patientsStroke patientsStroke locationOSA presenceIschemic strokeSleep apneaPrevalence of OSASeverity of OSAAcute ischemic stroke patientsTransient ischemic attackObstructive respiratory eventsMeasures of hypoxiaHigh overall prevalenceBrain imaging reportsIschemic attackPolysomnographic findingsOSA severityComplete polysomnographyRespiratory eventsInfarct locationOverall prevalenceVascular territoriesHIV status and the risk of ischemic stroke among men
Sico J, Chang C, So-Armah K, Justice A, Hylek E, Skanderson M, McGinnis K, Kuller L, Kraemer K, Rimland D, Bidwell Goetz M, Butt A, Rodriguez-Barradas M, Gibert C, Leaf D, Brown S, Samet J, Kazis L, Bryant K, Freiberg M, Chang C, So-Armah K, Justice A, Hylek E, Skanderson M, McGinnis K, Kuller L, Kraemer K, Rimland D, Goetz M, Butt A, Rodriguez Barradas M, Gibert C, Leaf D, Brown S, Samet J, Kazis L, Bryant K, Freiberg M. HIV status and the risk of ischemic stroke among men. Neurology 2015, 84: 1933-1940. PMID: 25862803, PMCID: PMC4433456, DOI: 10.1212/wnl.0000000000001560.Peer-Reviewed Original ResearchConceptsIschemic stroke riskVeterans Aging Cohort Study Virtual CohortIschemic stroke risk factorsStroke risk factorsHIV infectionUninfected veteransIschemic strokeStroke riskMale veteransComorbid diseasesRisk factorsSubstance useBaseline cardiovascular diseaseIschemic stroke rateRace/ethnicityHIV biomarkersMedian followStroke eventsHIV statusCardiovascular diseaseStroke rateClinical sitesHIVInfectionStroke
2011
Anemia is Associated with Poor Outcomes in Patients with Less Severe Ischemic Stroke
Sico JJ, Concato J, Wells CK, Lo AC, Nadeau SE, Williams LS, Peixoto AJ, Gorman M, Boice JL, Bravata DM. Anemia is Associated with Poor Outcomes in Patients with Less Severe Ischemic Stroke. Journal Of Stroke And Cerebrovascular Diseases 2011, 22: 271-278. PMID: 22100828, DOI: 10.1016/j.jstrokecerebrovasdis.2011.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnemiaBrain IschemiaChi-Square DistributionDisability EvaluationFemaleHospice CareHospital MortalityHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPatient AdmissionPatient DischargePredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeUnited StatesYoung AdultConceptsAcute ischemic strokeSevere ischemic strokeSevere strokeHospital mortalityIschemic strokeConsecutive ischemic stroke patientsHealth Stroke Scale scoreAdmission National InstitutesRole of anemiaStroke Scale scoreChronic kidney diseaseIschemic stroke patientsCongestive heart failureAcute myocardial infarctionAdmission anemiaCombined endpointRetrospective cohortStroke severitySymptom onsetHeart failureHospital admissionStroke patientsPoor outcomeKidney diseaseMyocardial infarctionAmbulatory blood pressure monitoring among patients with cerebrovascular disease
Sico JJ, Phipps MS, Yaggi HK, Burrus N, Ferguson J, McClain V, Austin C, Li X, Bravata DM. Ambulatory blood pressure monitoring among patients with cerebrovascular disease. Blood Pressure Monitoring 2011, 16: 211-217. PMID: 21885958, DOI: 10.1097/mbp.0b013e32834b4d6c.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringABP monitoringBlood pressure monitoringCerebrovascular diseaseStroke patientsPressure monitoringStroke care guidelinesBlood pressure valuesOngoing clinical trialsABP dataEnglish-language articlesNocturnal fallArm weaknessBlood pressureHypertension managementCare guidelinesPoor outcomeCase reportNeurological impairmentClinical trialsInclusion criteriaPatientsSystematic reviewSupport interventionsDisease