2021
Depression as a Risk Factor for Incident Ischemic Stroke Among HIV‐Positive Veterans in the Veterans Aging Cohort Study
Sico JJ, Kundu S, So‐Armah K, Gupta SK, Chang C, Butt AA, Gibert CL, Marconi VC, Crystal S, Tindle HA, Freiberg MS, Stewart JC. Depression as a Risk Factor for Incident Ischemic Stroke Among HIV‐Positive Veterans in the Veterans Aging Cohort Study. Journal Of The American Heart Association 2021, 10: e017637. PMID: 34169726, PMCID: PMC8403311, DOI: 10.1161/jaha.119.017637.Peer-Reviewed Original ResearchConceptsHIV-positive peopleBaseline antidepressant useCerebrovascular risk factorsRisk of strokeRisk factorsAlcohol use disorderStroke riskAntidepressant useUse disordersCocaine useSociodemographic characteristicsTraditional cerebrovascular risk factorsVeterans Aging Cohort StudyCox proportional hazards modelBackground HIV infectionHIV-specific factorsIndividual antiretroviral agentsAntiretroviral therapy useBaseline cardiovascular diseaseIndependent risk factorAging Cohort StudyIschemic stroke riskHIV-positive veteransProportional hazards modelUninfected veterans
2020
Posttraumatic Stress Disorder, Antidepressant Use, and Hemorrhagic Stroke in Young Men and Women
Gaffey AE, Rosman L, Burg MM, Haskell SG, Brandt CA, Skanderson M, Dziura J, Sico JJ. Posttraumatic Stress Disorder, Antidepressant Use, and Hemorrhagic Stroke in Young Men and Women. Stroke 2020, 52: 121-129. PMID: 33297868, PMCID: PMC7770089, DOI: 10.1161/strokeaha.120.030379.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderHemorrhagic strokeHealth care utilizationUse of SSRIsGreater riskSSRI useStroke riskCare utilizationStress disorderEffects of PTSDIncident hemorrhagic strokeMiddle-aged veteransModifiable risk factorsNon-pharmacological treatmentMultivariate Cox modelNorepinephrine reuptake inhibitorsOverall incidence rateHemorrhagic stroke riskSNRI useIncident strokeAntidepressant useReuptake inhibitorsComorbid conditionsLifestyle factorsPsychiatric comorbidity