2024
A common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder
Arutiunian V, Santhosh M, Neuhaus E, Sullivan C, Bernier R, Bookheimer S, Dapretto M, Geschwind D, Jack A, McPartland J, Van Horn J, Pelphrey K, Gupta A, Webb S, Network T. A common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder. Autism Research 2024 PMID: 38984666, DOI: 10.1002/aur.3193.Peer-Reviewed Original ResearchAutism spectrum disorderLanguage skillsCommunication abilitySpectrum disorderStructural language abilityStructural language skillsLow language skillsCommunication skillsMeasures of languageContactin-associated protein-like 2 geneYouth aged 7Verbal communication skillsCELF-4G allele homozygotesLanguage abilityLanguage variablesNon-verbal individualsVerbal youthLanguageNeurexin familyVineland-IICandidate genesGenomic DNAGenetic mechanismsGenetic variantsThe relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives
Arutiunian V, Santhosh M, Neuhaus E, Borland H, Tompkins C, Bernier R, Bookheimer S, Dapretto M, Gupta A, Jack A, Jeste S, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S. The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives. Molecular Autism 2024, 15: 19. PMID: 38711098, PMCID: PMC11075235, DOI: 10.1186/s13229-024-00598-1.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderElevated gamma powerLow language skillsGamma powerResponses to speech stimuliLanguage skillsLanguage functionFirst-degree relativesSpectrum disorderClinical Evaluation of Language FundamentalsCo-occurring language impairmentSpeech stimuliCortical gamma-band oscillationsHigh gamma powerSex-balanced sampleGamma-band oscillationsSample of participantsNonverbal IQLanguage impairmentASD participantsTD controlsNeural profilesAutism phenotypeTD groupLanguage FundamentalsConduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder
Newman B, Jacokes Z, Venkadesh S, Webb S, Kleinhans N, McPartland J, Druzgal T, Pelphrey K, Van Horn J, Consortium F. Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder. PLOS ONE 2024, 19: e0301964. PMID: 38630783, PMCID: PMC11023574, DOI: 10.1371/journal.pone.0301964.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial Communication QuestionnaireSpectrum disorderCharacteristics of autism spectrum disorderAssociated with higher scoresEtiology of autism spectrum disorderMagnetic resonance imagingNeurotypical participantsWhite matter skeletonCommunication QuestionnaireBehavioral functionsFunctional connectivityT1w/T2w ratioNeuronal differencesStructural connectivityAdolescent participantsHigher scoresConduction velocityCortexExtracellular waterDisordersResonance imagingDiffusion MRI techniquesAutism Spectrum Disorder in Adolescents and Adults: An Introduction
Volkmar F, Reichow B, McPartland J. Autism Spectrum Disorder in Adolescents and Adults: An Introduction. 2024, 1-16. DOI: 10.1007/978-3-031-46463-8_1.Peer-Reviewed Original ResearchSupport vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact
Zhang X, Noah J, Singh R, McPartland J, Hirsch J. Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact. Scientific Reports 2024, 14: 3232. PMID: 38332184, PMCID: PMC10853508, DOI: 10.1038/s41598-024-53942-z.Peer-Reviewed Original ResearchConceptsAutism Diagnostic Observation ScheduleAutism spectrum disorderAutism Diagnostic Observation Schedule scoresEye-to-eye contactSocial difficultiesNeural processesNeural responsesObservation ScheduleSymptoms of autism spectrum disorderBehavioural symptoms of autism spectrum disorderNeural activity patternsLive interaction paradigmTD groupSupport vector machineNeural mechanismsSymptom severityADOS scoresBehavioral symptomsSpectrum disorderASD diagnosisNeural dataActivity patternsAutismClassification methodMultivariate classification methods
2023
Investigating the Face Inversion Effect in Autism Across Behavioral and Neural Measures of Face Processing
Griffin J, Azu M, Cramer-Benjamin S, Franke C, Herman N, Iqbal R, Keifer C, Rosenthal L, McPartland J. Investigating the Face Inversion Effect in Autism Across Behavioral and Neural Measures of Face Processing. JAMA Psychiatry 2023, 80: 1026-1036. PMID: 37405787, PMCID: PMC10323765, DOI: 10.1001/jamapsychiatry.2023.2105.Peer-Reviewed Original ResearchFace processing systemFace inversion effectAutism spectrum disorderInversion effectFace processingNeurotypical sampleAutistic individualsEffect sizeHuman social cognitionPerformance differencesFace recognition taskPerformance-based measuresSocial cognitionNeural measuresNeurotypical individualsPsychological constructsNeural responsesSpectrum disorderElectrophysiological measuresRecognition taskBrain functioningBehavioral paradigmsRecognition demandsIdentity recognitionNeural systemsThe Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study
Shic F, Barney E, Naples A, Dommer K, Chang S, Li B, McAllister T, Atyabi A, Wang Q, Bernier R, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Johnson S, Sabatos‐DeVito M, Helleman G, Senturk D, Sugar C, Webb S, McPartland J, Chawarska K, Trials T. The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study. Autism Research 2023, 16: 2150-2159. PMID: 37749934, PMCID: PMC11003770, DOI: 10.1002/aur.3026.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial attention taskSchool-aged childrenAttention taskASD groupSpectrum disorderEye-tracking taskTotal T-scoreAttentional patternsAutism spectrumTD groupPresentation timeTrial feasibility studyGroup differencesPercent of timeOlder childrenTaskComparison groupToddlersT-scoreChildrenChildren 4Outcome variablesFaceCondition effectsDevelopment of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children
Finn C, Han G, Naples A, Wolf J, McPartland J. Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children. Autism Research 2023, 16: 2077-2089. PMID: 37638733, DOI: 10.1002/aur.3017.Peer-Reviewed Original ResearchConceptsPeak alpha frequencyAutism spectrum disorderCognitive abilitiesAutistic childrenNonverbal IQNeural maturationSpectrum disorderTypical age-related increaseAlpha frequencyDifferent developmental trajectoriesDistinct trajectoriesSample of childrenCurrent study clarifiesDiagnostic groupsNeurotypical childrenNeurotypical controlsBehavioral measuresDevelopmental trajectoriesDiagnostic statusAge-related increaseFunction of ageIQEffect of ageBivariate relationsPrevious findingsModeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Jourdon A, Wu F, Mariani J, Capauto D, Norton S, Tomasini L, Amiri A, Suvakov M, Schreiner J, Jang Y, Panda A, Nguyen C, Cummings E, Han G, Powell K, Szekely A, McPartland J, Pelphrey K, Chawarska K, Ventola P, Abyzov A, Vaccarino F. Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis. Nature Neuroscience 2023, 26: 1505-1515. PMID: 37563294, PMCID: PMC10573709, DOI: 10.1038/s41593-023-01399-0.Peer-Reviewed Original ResearchConceptsIdiopathic autism spectrum disorderCortical neuron subtypesAutism spectrum disorderEarly cortical developmentCortical organoidsCortical plateExcitatory neuronsCortical developmentRare formNeuron subtypesUnaffected fatherASD pathogenesisForebrain organoidsEarly neurogenesisRare variantsIdiopathic autismRisk genesTranscriptomic alterationsNeuronsProbandsSingle-cell transcriptomicsForebrain developmentSpectrum disorderTranscriptomic changesAlterations
2022
Neural correlates of eye contact and social function in autism spectrum disorder
Hirsch J, Zhang X, Noah J, Dravida S, Naples A, Tiede M, Wolf J, McPartland J. Neural correlates of eye contact and social function in autism spectrum disorder. PLOS ONE 2022, 17: e0265798. PMID: 36350848, PMCID: PMC9645655, DOI: 10.1371/journal.pone.0265798.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDorsal parietal regionsNeural correlatesEye contactLive eyesNeural responsesSpectrum disorderAutism Diagnostic Observation ScheduleUnderlying neural correlatesSocial Responsiveness ScaleGold standard measureCentral diagnostic criterionDiagnostic criteriaDiagnostic biomarkersSRS-2ADOS-2Responsiveness ScaleObservation ScheduleParietal regionsPupillometry dataNeural systemsEyesNatural interactionDisordersCorrelates
2021
Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia
Levy E, Isenstein E, Foss-Feig J, Srihari V, Anticevic A, Naples A, McPartland J. Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia. Review Journal Of Autism And Developmental Disorders 2021, 9: 521-554. PMID: 36568688, PMCID: PMC9783109, DOI: 10.1007/s40489-021-00260-z.Peer-Reviewed Original ResearchAutism spectrum disorderEvent-related potentialsSchizophrenia spectrum disordersSpectrum disorderFacial communicationResearch Domain Criteria frameworkSocial cognitionHeterogeneous clinical populationN170 latencySocial perceptionTransdiagnostic researchClinical populationsNeural activitySZ populationInconsistent findingsNeurodevelopmental disordersN170Criteria frameworkResearch findingsAreas of overlapDisordersN250CognitionElectrophysiological studiesPerceptionAn Electrocortical Measure Associated With Metarepresentation Mediates the Relationship Between Autism Symptoms and Theory of Mind
Libsack E, Trimber E, Hauschild K, Hajcak G, McPartland J, Lerner M. An Electrocortical Measure Associated With Metarepresentation Mediates the Relationship Between Autism Symptoms and Theory of Mind. Clinical Psychological Science 2021, 10: 324-339. PMID: 38736986, PMCID: PMC11086972, DOI: 10.1177/21677026211021975.Peer-Reviewed Original ResearchLate positive complexTheory of mindMental state inferencesLate slow waveASD symptom severityAutism spectrum disorderToM reasoningToM performanceElectrocortical measuresAutism symptomsERP componentsIndividual differencesPositive complexASD symptomsLPC scoresNeural mechanismsSpectrum disorderSymptom severityMetarepresentationDifferential recruitmentMindSlow wavesIndividualsASDAdolescentsConsiderations About How Emotional Intelligence can be Enhanced in Children With Autism Spectrum Disorder
Trevisan D, Abel E, Brackett M, McPartland J. Considerations About How Emotional Intelligence can be Enhanced in Children With Autism Spectrum Disorder. Frontiers In Education 2021, 6: 639736. DOI: 10.3389/feduc.2021.639736.Peer-Reviewed Original ResearchEmotional intelligenceLow emotional intelligencePoor emotional intelligenceAutism spectrum disorderPerceiving emotionsEI interventionsUnderstanding emotionsManaging emotionsContextual cuesCognitive intelligenceEmotional difficultiesSpectrum disorderEmotional learningSpecial education classroomsBody languageEmotionsAcademic successSchool settingsASDEducation classroomsIntelligenceTheoretical frameworkChildrenPerspective paperCues
2020
Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research Supplement
Zwaigenbaum L, Bauman M, Stone W, Yirmiya N, Estes A, Hansen R, McPartland J, Natowicz M, Choueiri R, Fein D, Kasari C, Pierce K, Buie T, Carter A, Davis P, Granpeesheh D, Mailloux Z, Newschaffer C, Robins D, Roley S, Wagner S, Wetherby A. Early Identification of Autism Spectrum Disorder: Recommendations for Practice and Research Supplement. 2020, 122-152. DOI: 10.1542/9781610024716-part03-ch009.Peer-Reviewed Original ResearchEarly Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research
Zwaigenbaum L, Bauman M, Choueiri R, Kasari C, Carter A, Granpeesheh D, Mailloux Z, Roley S, Wagner S, Fein D, Pierce K, Buie T, Davis P, Newschaffer C, Robins D, Wetherby A, Stone W, Yirmiya N, Estes A, Hansen R, McPartland J, Natowicz M. Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research. 2020, 269-290. DOI: 10.1542/9781610024716-part06-ch023.Peer-Reviewed Original ResearchResearch and training in autism spectrum disorder to catalyze the next genomic and neuroscience revolutions
Paşca SP, Veenstra-VanderWeele J, McPartland JC. Research and training in autism spectrum disorder to catalyze the next genomic and neuroscience revolutions. Molecular Psychiatry 2020, 26: 1429-1431. PMID: 32601454, DOI: 10.1038/s41380-020-0830-5.Peer-Reviewed Original ResearchAutism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms
Trevisan DA, Foss-Feig JH, Naples AJ, Srihari V, Anticevic A, McPartland JC. Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms. Frontiers In Psychiatry 2020, 11: 548. PMID: 32595540, PMCID: PMC7301837, DOI: 10.3389/fpsyt.2020.00548.Peer-Reviewed Original ResearchAutism spectrum disorderSpectrum disorderNegative symptomsAutism Diagnostic Observation SchedulePositive symptomsGold standard diagnostic assessmentHeterogenous neurodevelopmental disorderAnalysis of covarianceDSM-5 criteriaStereotyped languageTD adultsASD symptomsTypical developmentObservation ScheduleRepetitive behaviorsCommunicative behaviorNegative Syndrome ScaleStandardized measuresSZ groupSymptom domainsGroup differencesParticipant groupsSymptom overlapSZ symptomsNeurodevelopmental disordersSex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD
Lawrence KE, Hernandez LM, Bowman HC, Padgaonkar NT, Fuster E, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, Geschwind DH, McPartland JC, Nelson CA, Webb SJ, Pelphrey KA, Green SA, Bookheimer SY, Dapretto M, Consortium G. Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD. Cerebral Cortex 2020, 30: 5107-5120. PMID: 32350530, PMCID: PMC7391269, DOI: 10.1093/cercor/bhaa105.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCentral executive networkDefault mode networkFunctional connectivitySalience networkExecutive networkSymptomatology of ASDGreater functional connectivitySex-related biological factorsSample of girlsSN functional connectivitySex differencesAltered functional connectivityASD exhibitNeurotypical individualsNeurocognitive networksTypical developmentNeural mechanismsSpectrum disorderDefault modeMode networkParticipant sexMale samplesYouthGirlsHigher Depressive Symptoms Predict Lower Social Adaptive Functioning in Children and Adolescents with ASD
Duan S, Lee M, Wolf J, Naples AJ, McPartland JC. Higher Depressive Symptoms Predict Lower Social Adaptive Functioning in Children and Adolescents with ASD. Journal Of Clinical Child & Adolescent Psychology 2020, 51: 203-210. PMID: 32347746, DOI: 10.1080/15374416.2020.1750020.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAdaptive functioningDepressive symptomsHigher depressive symptomsDaily living skillsSocial adaptiveTypical developmentSocial skillsSpectrum disorderLiving skillsSocial domainsLower functioningAdaptive functionAdolescentsFunctioningDepressive symptomatologyChildrenDifferent domainsSkillsIQSymptomsPresent studyYears of ageImaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
Hernandez LM, Lawrence KE, Padgaonkar NT, Inada M, Hoekstra JN, Lowe JK, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland JC, Webb SJ, Pelphrey KA, Green SA, Geschwind DH, Bookheimer SY, Dapretto M. Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Translational Psychiatry 2020, 10: 82. PMID: 32127526, PMCID: PMC7054353, DOI: 10.1038/s41398-020-0750-9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeurotypical malesOXTR variantsBrain connectivityNeurobiological mechanismsPrefrontal cortexFunctional connectivityNetwork resting-state functional connectivityManifestation of ASDReward-related brain regionsResting-state functional connectivityBrain areasGreater functional connectivityPrefrontal brain areasFemale protective effectSubcortical brain areasSpectrum disorderMotor learningOXTR geneDiagnosis relateHigh OXTRBrain regionsGenetic riskSubcortical regionsSex differences