2015
Oxytocin-augmented labor and risk for autism in males
Weisman O, Agerbo E, Carter CS, Harris JC, Uldbjerg N, Henriksen TB, Thygesen M, Mortensen PB, Leckman JF, Dalsgaard S. Oxytocin-augmented labor and risk for autism in males. Behavioural Brain Research 2015, 284: 207-212. PMID: 25707712, DOI: 10.1016/j.bbr.2015.02.028.Peer-Reviewed Original ResearchConceptsSynthetic oxytocinInfant developmentICD-10 DCRSingleton live birthsAugmentation of laborAutistic disorderDose-dependent effectAugment laborMaternal exposureLive birthsModest associationEpidemiological analysisAdverse effectsOxytocinPlausible associationRiskMalesInconsistent findingsDisordersFuture studiesBirthAssociationAutismFindingsAugmentation
2011
Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism
Fernandez TV, Sanders SJ, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO, Raubeson MJ, Song Y, Yasuno K, Ho WS, Bilguvar K, Glessner J, Chu SH, Leckman JF, King RA, Gilbert DL, Heiman GA, Tischfield JA, Hoekstra PJ, Devlin B, Hakonarson H, Mane SM, Günel M, State MW. Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism. Biological Psychiatry 2011, 71: 392-402. PMID: 22169095, PMCID: PMC3282144, DOI: 10.1016/j.biopsych.2011.09.034.Peer-Reviewed Original ResearchConceptsCopy number variationsRare copy number variationsNovel risk regionsEnrichment of genesGamma-aminobutyric acid receptor genesNervous system developmentEtiology of TSParent-child triosRare copy number variantsCopy number variantsGene mappingPathway analysisDe novo eventsAxon guidanceCell adhesionMolecular pathwaysNumber variationsRelevant pathwaysCNV analysisNumber variantsGenesReceptor geneDe novoNovo eventsPathwayRisperidone-Related Improvement of Irritability in Children with Autism Is not Associated with Changes in Serum of Epidermal Growth Factor and Interleukin-13
Tobiasova Z, van der Lingen KH, Scahill L, Leckman JF, Zhang Y, Chae W, McCracken JT, McDougle CJ, Vitiello B, Tierney E, Aman MG, Arnold LE, Katsovich L, Hoekstra PJ, Volkmar F, Bothwell AL, Kawikova I. Risperidone-Related Improvement of Irritability in Children with Autism Is not Associated with Changes in Serum of Epidermal Growth Factor and Interleukin-13. Journal Of Child And Adolescent Psychopharmacology 2011, 21: 555-564. PMID: 22070180, PMCID: PMC3279715, DOI: 10.1089/cap.2010.0134.Peer-Reviewed Original ResearchConceptsMedication-free subjectsEpidermal growth factorHealthy controlsInflammatory markersIL-13IL-1 receptor antagonistGrowth factorSerum inflammatory markersChemoattractant protein-1Placebo groupClinical improvementBaseline visitIL-17Serum levelsCytokine concentrationsInflammatory moleculesSerum concentrationsClinical trialsHealthy subjectsIL-1Interleukin-13RisperidoneAltered levelsProtein 1Diagnosis of autism
2008
Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen CM, Han SS, Kochetkova A, Babitz T, Chang JT, Volkmar FR, Leckman JF, Grigorenko EL. Genes Controlling Affiliative Behavior as Candidate Genes for Autism. Biological Psychiatry 2008, 63: 911-916. PMID: 18207134, PMCID: PMC2386897, DOI: 10.1016/j.biopsych.2007.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAsperger SyndromeAutistic DisorderBehaviorChildDopamine beta-HydroxylaseFamily HealthFemaleGenetic LinkageGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMaleOrganizational AffiliationOxytocinProlactinProto-Oncogene Proteins c-fosReceptors, OxytocinReceptors, ProlactinConceptsHeterogeneous genetic factorsAllelic associationCandidate genesAssociation analysisGenetic linkageManifestation of ASDGenesGenetic variantsAllelic variantsFBAT softwareGenetic factorsComplex etiologyIndependent replicationNeurodevelopmental disordersOXTR geneAffiliative behaviorMultiple facetsVariantsPRLRPhenotypeHypothesis
2004
Obsessive‐compulsive symptoms in parents of Tourette syndrome probands and autism spectrum disorder probands
KANO Y, OHTA M, NAGAI Y, PAULS DL, LECKMAN JF. Obsessive‐compulsive symptoms in parents of Tourette syndrome probands and autism spectrum disorder probands. Psychiatry And Clinical Neurosciences 2004, 58: 348-352. PMID: 15298645, DOI: 10.1111/j.1440-1819.2004.01266.x.Peer-Reviewed Original Research
2002
Maternal behavior and developmental psychopathology
Leckman JF, Herman AE. Maternal behavior and developmental psychopathology. Biological Psychiatry 2002, 51: 27-43. PMID: 11801229, DOI: 10.1016/s0006-3223(01)01277-x.Peer-Reviewed Original ResearchConceptsMaternal behaviorNeuronal nitric oxide synthaseEstrogen alpha receptorsNitric oxide synthaseMouse strain backgroundDopamine beta hydroxylaseGene knockout dataAnimal model systemsGene knockout studiesGene knockout technologyPeer-reviewed journalsOxide synthaseAlpha receptorsBehavioral deficitsSearch of literatureBeta hydroxylaseDisease pathogenesisTranscription factorsMolecular basisGenetic factorsKnockout studiesSpecific genesKnockout dataKnockout technologyStrain background
1999
Oxytocin, vasopressin, and autism: is there a connection?
Insel T, O’Brien D, Leckman J. Oxytocin, vasopressin, and autism: is there a connection? Biological Psychiatry 1999, 45: 145-157. PMID: 9951561, DOI: 10.1016/s0006-3223(98)00142-5.Peer-Reviewed Original ResearchConceptsVasopressin neurotransmissionAvailable preclinical evidencePreclinical evidenceClinical studiesAnimal studiesRodent brainPeptide receptorFeatures of autismOxytocinVasopressinGenetic disordersCompulsive behaviorsNeurotransmissionNormal expressionDevelopmental disordersSocial impairmentReceptorsCommunication deficitsDisordersSpecies-typical social behaviorsNeurobiological approachAutismEvidenceUnique effectsExpression
1985
Computed tomographic brain scanning in four neuropsychiatric disorders of childhood
Harcherik DF, Cohen DJ, Ort S, Paul R, Shaywitz BA, Volkmar FR, Rothman SL, Leckman JF. Computed tomographic brain scanning in four neuropsychiatric disorders of childhood. American Journal Of Psychiatry 1985, 142: 731-734. PMID: 3859227, DOI: 10.1176/ajp.142.6.731.Peer-Reviewed Original ResearchConceptsBrain densityVentricular volumeNeuropsychiatric disordersMedical control patientsTomographic brain scanningVentricle-brain ratioTotal ventricular volumeVentricular volume ratioControl patientsMedical patientsVentricular asymmetryBrain scanningControl groupCAT scanPatientsDiagnostic groupsPatient diagnosisNeuropsychiatric patientsSignificant differencesDiagnosisDisordersChildhoodGroup
1984
Fragile X in a Survey of 75 Autistic Males
Watson MS, Leckman JF, Annex B, Breg WR, Boles D, Volkmar FR, Cohen DJ, Carter C. Fragile X in a Survey of 75 Autistic Males. New England Journal Of Medicine 1984, 310: 1462. PMID: 6717529, DOI: 10.1056/nejm198405313102214.Peer-Reviewed Original Research