2020
The prevalence of behavioral and emotional problems among Chinese school children and adolescents aged 6–16: a national survey
Cui Y, Li F, Leckman JF, Guo L, Ke X, Liu J, Zheng Y, Li Y. The prevalence of behavioral and emotional problems among Chinese school children and adolescents aged 6–16: a national survey. European Child & Adolescent Psychiatry 2020, 30: 233-241. PMID: 32172341, DOI: 10.1007/s00787-020-01507-6.Peer-Reviewed Original ResearchMeSH KeywordsAffective SymptomsChildChild Behavior DisordersChinaFemaleHumansMaleMental DisordersPrevalenceSurveys and QuestionnairesConceptsChild Behavior ChecklistEmotional problemsMental health providersNational surveyChinese school childrenLong-term benefitsAchenbach Child Behavior ChecklistHigh prevalenceLarge cohortPediatric psychiatristHealth providersMental disordersMultistage clusterPrevalenceCohortMental healthCBCL scoresOlder cohortBehavior ChecklistYounger cohortsChildren
2017
A double-blind randomized pilot trial comparing computerized cognitive exercises to Tetris in adolescents with attention-deficit/hyperactivity disorder
Bikic A, Christensen TØ, Leckman JF, Bilenberg N, Dalsgaard S. A double-blind randomized pilot trial comparing computerized cognitive exercises to Tetris in adolescents with attention-deficit/hyperactivity disorder. Nordic Journal Of Psychiatry 2017, 71: 455-464. PMID: 28598701, DOI: 10.1080/08039488.2017.1328070.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderComputerized cognitive exercisesCognitive exercisesHyperactivity disorderComputer game TetrisSignificant intra-group changesADHD symptom measuresSignificant group differencesLarge effect sizesDouble-blind randomized pilot trialBrain trainingSustained attentionCognitive testsGame TetrisMotivation questionnaireHome-based interventionGroup differencesSignificant beneficial effectRandomized pilot trialActive placeboIntra-group changesTetrisAdolescentsEffect sizeBeneficial effects
2015
Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation
Lebowitz ER, Leckman JF, Feldman R, Zagoory-Sharon O, McDonald N, Silverman WK. Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation. Psychoneuroendocrinology 2015, 65: 35-43. PMID: 26716876, PMCID: PMC4895196, DOI: 10.1016/j.psyneuen.2015.12.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety, SeparationChildFemaleHumansMaleMother-Child RelationsMothersOxytocinPituitary HormonesSalivaSelf ReportSurveys and QuestionnairesConceptsSalivary OT levelsFamily accommodationSeparation anxiety disorderYouth anxietyAnxiety disordersAnxious youthInterpersonal behaviorSeparation anxietyOT levelsDSM-5 anxiety disordersSeparation anxiety symptomsTreatment of anxietyNeuropeptide oxytocinSalivary OTClinical anxietyMaternal ratingsSalivary oxytocinAnxiety symptomsOxytocinergic systemRegulation of anxietyAnxious behaviorOwn behaviorAnxiety assessmentAnxietyParental involvementObsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children
Alvarenga PG, do Rosario MC, Cesar RC, Manfro GG, Moriyama TS, Bloch MH, Shavitt RG, Hoexter MQ, Coughlin CG, Leckman JF, Miguel EC. Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children. European Child & Adolescent Psychiatry 2015, 25: 175-182. PMID: 26015374, DOI: 10.1007/s00787-015-0723-3.Peer-Reviewed Original ResearchConceptsFamily History ScreenObsessive-compulsive disorderObsessive-compulsive symptomsSchool-aged childrenChild Behavior ChecklistUnaffected controlsPediatric-onset obsessive-compulsive disorderPresence of OCSPopulation-based studyComorbid psychiatric disordersMajor depressive disorderWell-Being AssessmentOCD groupBrazilian school childrenGroup of childrenPsychiatric comorbidityDepressive disorderClinical impactFunctional impairmentPsychiatric disordersClinical problemOCS groupDiagnostic groupsSignificant socio-demographic differencesSocio-demographic differences
2012
FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS
Lebowitz ER, Woolston J, Bar‐Haim Y, Calvocoressi L, Dauser C, Warnick E, Scahill L, Chakir AR, Shechner T, Hermes H, Vitulano LA, King RA, Leckman JF. FAMILY ACCOMMODATION IN PEDIATRIC ANXIETY DISORDERS. Depression And Anxiety 2012, 30: 47-54. PMID: 22965863, PMCID: PMC3932435, DOI: 10.1002/da.21998.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersFamily Accommodation ScaleFamily accommodationAnxiety disordersMeasures of anxietyFamilies of childrenObsessive-compulsive disorderGood internal consistencyTwo-factor solutionAnxious childrenPediatric anxietyAccommodation ScaleSeparation anxietyGreater symptom severityAnxiety symptomsCompulsive disorderDivergent validityFamily routinesAnxietyDiagnostic InterviewPoor treatment outcomesInternal consistencySymptom severityMost parentsFactor analysis
2011
Love Alters Autonomic Reactivity to Emotions
Schneiderman I, Zilberstein-Kra Y, Leckman JF, Feldman R. Love Alters Autonomic Reactivity to Emotions. Emotion 2011, 11: 1314-1321. PMID: 22142209, DOI: 10.1037/a0024090.Peer-Reviewed Original ResearchCoercive and disruptive behaviors in pediatric obsessive–compulsive disorder
Lebowitz ER, Omer H, Leckman JF. Coercive and disruptive behaviors in pediatric obsessive–compulsive disorder. Depression And Anxiety 2011, 28: 899-905. PMID: 21769998, PMCID: PMC4006629, DOI: 10.1002/da.20858.Peer-Reviewed Original Research
2010
Perceived quality of maternal care in childhood and structure and function of mothers' brain
Kim P, Leckman JF, Mayes LC, Newman M, Feldman R, Swain JE. Perceived quality of maternal care in childhood and structure and function of mothers' brain. Developmental Science 2010, 13: 662-673. PMID: 20590729, PMCID: PMC3974609, DOI: 10.1111/j.1467-7687.2009.00923.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingCryingFemaleHumansInfant, NewbornMagnetic Resonance ImagingMaternal AgeMaternal BehaviorMiddle AgedSurveys and QuestionnairesYoung AdultConceptsMiddle frontal gyrusSuperior temporal gyrusMaternal careTemporal gyrusHuman mothersFrontal gyrusInfant stimuliFusiform gyrusFirst postpartum monthLarger gray matter volumeGray matter volumeMagnetic resonance imagingHigh maternal careLow maternal careMother's brainPostpartum monthsLong-term effectsOrbital gyrusAnimal studiesBrain areasMatter volumeNeglectful motheringResonance imagingBrain regionsHeightened stress reactivitySevere psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome
Motlagh MG, Katsovich L, Thompson N, Lin H, Kim YS, Scahill L, Lombroso PJ, King RA, Peterson BS, Leckman JF. Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome. European Child & Adolescent Psychiatry 2010, 19: 755-764. PMID: 20532931, PMCID: PMC3932440, DOI: 10.1007/s00787-010-0115-7.Peer-Reviewed Original ResearchConceptsHeavy maternal smokingPerinatal risk factorsAttention-deficit/hyperactivity disorderSevere psychosocial stressRisk factorsMaternal smokingTourette syndromePsychosocial stressUnaffected control childrenControl childrenHeavy cigarette smokingHigh-risk populationStatistical significanceDiagnosis of ADHDComorbid Tourette's syndromeHigh rateMothers of childrenMaternal report dataHeavy smokingPerinatal historyCigarette smokingOdds ratioPsychiatric assessmentSmokingStandardized questionnaire
2009
Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior
Sukhodolsky DG, Vitulano LA, Carroll DH, McGuire J, Leckman JF, Scahill L. Randomized Trial of Anger Control Training for Adolescents With Tourette's Syndrome and Disruptive Behavior. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 413-421. PMID: 19242384, DOI: 10.1097/chi.0b013e3181985050.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAngerAttention Deficit and Disruptive Behavior DisordersChildFemaleHumansMaleObserver VariationParentsSelf EfficacySurveys and QuestionnairesTeachingTourette SyndromeConceptsClinical Global Impressions-Improvement scaleTourette syndromeACT groupControl trainingTAU control groupPrimary outcome measureIndependent evaluatorsAnger control trainingRating Scale scoresDisruptive behaviorEnd point evaluationLarge trialsBehavior rating scale scoresRandomized subjectsTAU conditionOutcome measuresScale scoreControl groupSyndromeRating ScaleACT conditionBehavior Rating ScaleAdolescentsTrialsDisruptive Behavior Rating Scale
2008
Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder
Bloch MH, Landeros-Weisenberger A, Rosario MC, Pittenger C, Leckman JF. Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2008, 165: 1532-1542. PMID: 18923068, PMCID: PMC3972003, DOI: 10.1176/appi.ajp.2008.08020320.Peer-Reviewed Original Research
2007
Obsessive-Compulsive Disorder: An Open-Label Pilot Trial of Escitalopram
Galvão-de Almeida A, Quarantini LC, Góis CR, Santos-Jesus R, Miranda-Scippa AM, de Oliveira IR, da Silva Prado H, Leckman JF, Rosário MC. Obsessive-Compulsive Disorder: An Open-Label Pilot Trial of Escitalopram. CNS Spectrums 2007, 12: 519-524. PMID: 17603402, DOI: 10.1017/s1092852900021258.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderYale-Brown ObsessiveTreatment responseOpen-label pilot trialSelective serotonin reuptake inhibitorsFourth Edition Axis IOpen-label studySerotonin reuptake inhibitorsOpen-label natureEdition Axis IStructured Clinical InterviewTotal Yale-Brown ObsessiveCompulsive Scale scoresReuptake inhibitorsDosage adjustmentNew medicationsPilot trialAxis IClinical InterviewPatientsScale scoreEscitalopramExperienced psychiatristsMental disordersUseful option
2006
Fine‐motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome
Bloch MH, Sukhodolsky DG, Leckman JF, Schultz RT. Fine‐motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome. Journal Of Child Psychology And Psychiatry 2006, 47: 551-559. PMID: 16712631, DOI: 10.1111/j.1469-7610.2005.01561.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasal GangliaChildFemaleFunctional LateralityHand StrengthHumansMaleMotor Skills DisordersNeuropsychological TestsObsessive-Compulsive DisorderPredictive Value of TestsPsychologyPsychomotor PerformanceSeverity of Illness IndexSocial BehaviorSurveys and QuestionnairesTourette SyndromeConceptsGlobal psychosocial functioningPurdue Pegboard TestFine motor skill deficitsTourette syndromeTic severityPegboard TestPsychosocial functioningTic symptomsTS patientsNeuropsychological testsStudy of TSBasal ganglia dysfunctionVisual-Motor Integration TestBeery Visual-Motor Integration TestLogistic regression analysisOrdinal logistic regression analysisFine motor coordinationMotor skill deficitsNeuropsychological testing batteryGanglia dysfunctionVisual-motor integrationClinical evaluationClinical assessmentClinical measuresNeuropsychological testingDisruptive behavior problems in a community sample of children with tic disorders.
Scahill L, Williams S, Schwab-Stone M, Applegate J, Leckman JF. Disruptive behavior problems in a community sample of children with tic disorders. Advances In Neurology 2006, 99: 184-90. PMID: 16536365.Peer-Reviewed Original Research
2005
Adaptive, Emotional, and Family Functioning of Children With Obsessive-Compulsive Disorder and Comorbid Attention Deficit Hyperactivity Disorder
Sukhodolsky DG, do Rosario-Campos MC, Scahill L, Katsovich L, Pauls DL, Peterson BS, King RA, Lombroso PJ, Findley DB, Leckman JF. Adaptive, Emotional, and Family Functioning of Children With Obsessive-Compulsive Disorder and Comorbid Attention Deficit Hyperactivity Disorder. American Journal Of Psychiatry 2005, 162: 1125-1132. PMID: 15930061, PMCID: PMC2291297, DOI: 10.1176/appi.ajp.162.6.1125.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAttention Deficit Disorder with HyperactivityChildComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersEmotionsFamily HealthFemaleHealth StatusHumansMaleObsessive-Compulsive DisorderPersonality InventoryPsychiatric Status Rating ScalesSurveys and QuestionnairesConceptsAttention deficit hyperactivity disorderObsessive-compulsive disorderComorbid attention deficit hyperactivity disorderDiagnosis of OCDDeficit hyperactivity disorderFamily functioningEmotional adjustmentHyperactivity disorderVineland Adaptive Behavior ScalesSelf-reported anxietyDaily living skillsAdaptive Behavior ScalesAdolescents ages 7Self-reported depressionBest-estimate DSM-IV diagnosesGroup of childrenAdaptive functioningLevel of impairmentChild functioningParent ratingsComparison childrenEmotional functioningComprehensive batteryLiving skillsDSM-IV diagnosis
2003
Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder
FINDLEY DB, LECKMAN JF, KATSOVICH L, LIN H, ZHANG H, GRANTZ H, OTKA J, LOMBROSO PJ, KING RA. Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 450-457. PMID: 12649632, DOI: 10.1097/01.chi.0000046816.95464.ef.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeDaily Life Stressors ScalePsychosocial stressAge-matched control subjectsClinician ratingsClinical rating instrumentGlobal clinician ratingsTime pointsGlobal Stress IndexCross-sectional ratingsEarly-onset obsessive-compulsive disorderPsychometric propertiesControl subjectsClinical severityObsessive-compulsive symptom severityStudy of childrenAcceptable psychometric propertiesStress indexSymptom severitySyndromePossible differential contributionInterrater reliabilityStressor ScaleDisorders